Search results for "Support Vector Machine"
showing 10 items of 306 documents
<strong>Machine Learning and Atom-Based Quadratic Indices for Proteasome Inhibition Prediction </strong>
2015
The atom-based quadratic indices are used in this work together with some machine learning techniques that includes: support vector machine, artificial neural network, random forest and k-nearest neighbor. This methodology is used for the development of two quantitative structure-activity relationship (QSAR) studies for the prediction of proteasome inhibition. A first set consisting of active and non-active classes was predicted with model performances above 85% and 80% in training and validation series, respectively. These results provided new approaches on proteasome inhibitor identification encouraged by virtual screenings procedures. .
Predictive modeling of aryl hydrocarbon receptor (AhR) agonism
2020
Abstract The aryl hydrocarbon receptor (AhR) plays a key role in the regulation of gene expression in metabolic machinery and detoxification systems. In the recent years, this receptor has attracted interest as a therapeutic target for immunological, oncogenic and inflammatory conditions. In the present report, in silico and in vitro approaches were combined to study the activation of the AhR. To this end, a large database of chemical compounds with known AhR agonistic activity was employed to build 5 classifiers based on the Adaboost (AdB), Gradient Boosting (GB), Random Forest (RF), Multilayer Perceptron (MLP) and Support Vector Machine (SVM) algorithms, respectively. The built classifier…
Multidimensional Model Design using Data Mining: A Rapid Prototyping Methodology
2017
[Departement_IRSTEA]Ecotechnologies [TR1_IRSTEA]MOTIVE; International audience; Designing and building a Data Warehouse (DW), and associated OLAP cubes, are long processes, during which decision-maker requirements play an important role. But decision-makers are not OLAP experts and can find it difficult to deal with the concepts behind DW and OLAP. To support DW design in this context, we propose: (i) a new rapid prototyping methodology, integrating two different DM algorithms, to define dimension hierarchies according to decision-maker knowledge; (ii) a complete UML Profile, to define a DW schema that integrates both the DM algorithms; (iii) a mapping process to transform multidimensional …
Regularization operators for natural images based on nonlinear perception models.
2006
Image restoration requires some a priori knowledge of the solution. Some of the conventional regularization techniques are based on the estimation of the power spectrum density. Simple statistical models for spectral estimation just take into account second-order relations between the pixels of the image. However, natural images exhibit additional features, such as particular relationships between local Fourier or wavelet transform coefficients. Biological visual systems have evolved to capture these relations. We propose the use of this biological behavior to build regularization operators as an alternative to simple statistical models. The results suggest that if the penalty operator take…
Non-linear System Identification with Composite Relevance Vector Machines
2007
Nonlinear system identification based on relevance vector machines (RVMs) has been traditionally addressed by stacking the input and/or output regressors and then performing standard RVM regression. This letter introduces a full family of composite kernels in order to integrate the input and output information in the mapping function efficiently and hence generalize the standard approach. An improved trade-off between accuracy and sparsity is obtained in several benchmark problems. Also, the RVM yields confidence intervals for the predictions, and it is less sensitive to free parameter selection. Teoría de la Señal y Comunicaciones
Discrete Time Signal Processing Framework with Support Vector Machines
2007
Digital signal processing (DSP) of time series using SVM has been addressed in the literature with a straightforward application of the SVM kernel regression, but the assumption of independently distributed samples in regression models is not fulfilled by a time-series problem. Therefore, a new branch of SVM algorithms has to be developed for the advantageous application of SVM concepts when we process data with underlying time-series structure. In this chapter, we summarize our past, present, and future proposal for the SVM-DSP frame-work, which consists of several principles for creating linear and nonlinear SVM algorithms devoted to DSP problems. First, the statement of linear signal mod…
A genetic algorithm approach to purify the classifier training labels for the analysis of remote sensing imagery
2017
This paper proposes a Genetic Algorithm (GA) approach to clean a given classifier training set for remote sensing image analysis. Starting from an initial set of training data, the new method called GA-Training Label Purifying (GA-TLP) consists of the significant training sample selection using GAs in order to maximize the classifier accuracy. This means to retain the most informative samples and to remove the uncertain, redundant, and misclassified ones. As a result of the selection process, we can obtain a purified training set. The proposed model is implemented and evaluated using a LANDSAT 7 ETM+ image. The experimental results confirm the effectiveness of the proposed approach.
On Obtaining Classification Confidence, Ranked Predictions and AUC with Tsetlin Machines
2020
Tsetlin machines (TMs) are a promising approach to machine learning that uses Tsetlin Automata to produce patterns in propositional logic, leading to binary (hard) classifications. In many applications, however, one needs to know the confidence of classifications, e.g. to facilitate risk management. In this paper, we propose a novel scheme for measuring TM confidence based on the logistic function, calculated from the propositional logic patterns that match the input. We then use this scheme to trade off precision against recall, producing area under receiver operating characteristic curves (AUC) for TMs. Empirically, using four real-world datasets, we show that AUC is a more sensitive meas…
A General Frame for Building Optimal Multiple SVM Kernels
2012
The aim of this paper is to define a general frame for building optimal multiple SVM kernels. Our scheme follows 5 steps: formal representation of the multiple kernels, structural representation, choice of genetic algorithm, SVM algorithm, and model evaluation. The computation of the optimal parameter values of SVM kernels is performed using an evolutionary method based on the SVM algorithm for evaluation of the quality of chromosomes. After the multiple kernel is found by the genetic algorithm we apply cross validation method for estimating the performance of our predictive model. We implemented and compared many hybrid methods derived from this scheme. Improved co-mutation operators are u…
Toward Self-Supervised Feature Learning for Online Diagnosis of Multiple Faults in Electric Powertrains
2021
This article proposes a novel online fault diagnosis scheme for industrial powertrains without using historical faulty or labeled training data. The proposed method combines a one-class support vector machine (SVM) based anomaly detection and supervised convolutional neural network (CNN) algorithms to online detect multiple faults and fault severities under variable speeds and loads. The one-class SVM algorithm is to derive a score for defining faults or health classes in the first stage, and the resulting health classes are used as the training data for the CNN-based classifier in the second stage. Within this framework, the self-supervised learning of the proposed CNN algorithm allows the…