Search results for "Surveillance"
showing 10 items of 494 documents
Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells
2021
Abstract Regulatory T (Treg) cells, which are essential for maintaining self-tolerance, inhibit anti-tumor immunity, consequently hindering protective cancer immunosurveillance, and hampering effective anti-tumor immune responses in tumor-bearing hosts. Here, we show that depletion of Treg cells via targeting glycoprotein A repetitions predominant (GARP) induces effective anti-tumor immune responses. GARP was specifically expressed by highly suppressive Treg cells in the tumor microenvironment (TME) of multiple cancer types in humans. In the periphery, GARP was selectively induced in Treg cells, but not in effector T cells, by polyclonal stimulation. DS-1055a, a novel afucosylated anti-huma…
Systematic analysis of the scientific literature on population surveillance
2020
Abstract Introduction Population surveillance provides data on the health status of the population through continuous scrutiny of different indicators. Identifying risk factors is essential for the quickly detecting and controlling of epidemic outbreaks and reducing the incidence of cross-infections and non-communicable diseases. The objective of the present study is to analyze research on population surveillance, identifying the main topics of interest for investigators in the area. Methodology We included documents indexed in the Web of Science Core Collection in the period from 2000 to 2019 and assigned with the generic Medical Subject Heading (MeSH) “population surveillance” or its rela…
NKp30 isoforms and NKp30 ligands are predictive biomarkers of response to imatinib mesylate in metastatic GIST patients
2016
International audience; Despite effective targeted therapy acting on KIT and PDGFRA tyrosine kinases, gastrointestinal stromal tumors (GIST) escape treatment by acquiring mutations conveying resistance to imatinib mesylate (IM). Following the identification of NKp30-based immunosurveillance of GIST and the off-target effects of IM on NK cell functions, we investigated the predictive value of NKp30 isoforms and NKp30 soluble ligands in blood for the clinical response to IM. The relative expression and the proportions of NKp30 isoforms markedly impacted both event-free and overall survival, in two independent cohorts of metastatic GIST. Phenotypes based on disbalanced NKp30B/NKp30C ratio (Del…
Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses
2016
Lau et al. show that the FLT3-ITD mutation directly affects dendritic cell development in preleukemic mice, indirectly modulating T cell homeostasis and supporting the expansion of regulatory T cells.
Tactics of invisibility : How people in vulnerable positions make datafied everyday life livable
2022
Various data platforms force the individual into constant presence and visibility. However, the ways in which datafied environments relate to experienced vulnerabilities in our everyday lives remain unclear. Through diaries produced by and interviews with participants from three groups who occupy presumably vulnerable positions and who currently live in Finland, we explore the ways in which people challenge expectations and prior assumptions related to forced visibility. Using the concept of tactics developed by de Certeau, we aim to understand how individuals make everyday surveillance culture livable through what we call tactics of invisibility. Based on our analysis, we identify three k…
Côté mauvaises herbes, tir de barrage sur trois envahissantes
2006
National audience; Les plantes envahissantes sont évoquées à la conférence sur les zones non agricoles de l'AFPPà Avignon les 11 et 12octobre 2006. La situation à leur égard en France et en Europe est présentée, notamment les dispositions réglementaires et l'identité des 34 principales espèces. Deux communications traitent de l'ambroisie à feuille d'armoise Ambrosia artemisiifolia. Un point sur les méthodes de lutte mécanique, chimique, etc.) insiste sur l'intérêt de la prévention (enherbement, etc.)et de la concertation entre acteurs agricoles et non agricoles. Des essais de lutte chimique (glyphosate ou glufosinate-ammonium en 2004 et 2005, les montrent équivalents et intéressants en débu…
Epidemiology of congenital diaphragmatic hernia in Europe: a register-based study.
2015
INTRODUCTION: Published prevalence rates of congenital diaphragmatic hernia (CDH) vary. This study aims to describe the epidemiology of CDH using data from high-quality, population-based registers belonging to the European Surveillance of Congenital Anomalies (EUROCAT).METHODS: Cases of CDH delivered between 1980 and 2009 notified to 31 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept.RESULTS: There were 3373 CDH cases reported among 12 155 491 registered births. Of 3131 singleton cases, 353 (10.4%) were associated wit…
METHODOLOGICAL ASPECTS IN THE DEVELOPMENT OF THE LIFESTYLE SURVEILLANCE TOOLKIT IN THE ASSO PROJECT
2012
Following the presentation of the ASSO Project, as discussed in the previous issue of JSSL (Tabacchi G. 2011; 1-3: 267-269 ), one of the first objectives of the study is to develop helpful and efficient tools to create a webbased software for the collection of data on adolescent lifestyles. Different methods have been developed and used throughout Europe to collect information on adolescent lifestyles. In order to select the best methods to be used in the ASSO project, a Systematic Literature Review (SLR) on the most valid dietary and physical activity/fitness assessment methods used in the target population has been perfomed. After the SLR and a meta-analysis of the retrieved studies, diff…
Adolescence Surveillance System for Obesity Prevention (ASSO) in Europe
2017
Adolescents' obesity is a major concern in our modern life that could lead to significant increase in the rate of obese future generations and consequently in the health budget. The ASSO (Adolescence Surveillance System for Obesity prevention) project in Italy is tackling this new pandemic using the new e-technology through a multi facets monitoring system on life style including food consumptions, meal patterns and habits, alcohol, smoking, physical activity, fitness and sedentariness, and biological/genetic, and socio-cultural/environmental characteristics of adolescents. The project has been recently piloted in the South of the country. This chapter summarizes the design and structure of…
From Graz to Göttingen: Neugebauer’s Early Intellectual Journey
2016
Otto Neugebauer’s early academic career was marked by a series of transitions. His interests shifted from physics to mathematics, and finally to the history of ancient mathematics and exact sciences. Yet even from his early years in Graz, Neugebauer was strongly attracted to the mathematical culture of Gottingen. When he arrived there in 1922, he quickly established a strong personal friendship with Richard Courant, the newly appointed Director of the Mathematics Institute. Neugebauer and Courant worked together closely up until 1933, when the Nazi government decimated the Gottingen scientific community. In this essay, Neugebauer’s historical work and his vision for a new approach to the st…