Search results for "System a"

Lunasin-induced behavioural effects in mice: Focus on the dopaminergic system

2013

The present study for the first time is devoted to identify central effects of synthetic lunasin, a 43 amino acid peptide. A markedly expressed neuroleptic/cataleptic effect was observed at low (0.1-10 nmol/mouse) centrally administered doses in male C57Bl/6 mice. Lunasin considerably reduced the amphetamine hyperlocomotion but weakly apomorphine climbing behaviour. No influence on ketamine and bicuculline effects was observed. Binding assay studies demonstrated modest affinity of lunasin for the dopamine D₁ receptor (Ki=60 ± 15 μM). In a functional assay of cAMP accumulation on live cells lunasin antagonised apomorphine effect on D₁ receptor activation (pEC₅₀=6.1 ± 0.3), but had no effect …

Marginal and Internal Precision of Zirconia Four-Unit Fixed Partial Denture Frameworks Produced Using Four Milling Systems

2021

Background: CAD/CAM systems enable the production of fixed partial dentures with small and reproducible internal and marginal gaps. Purpose: The purpose of this study was to evaluate the reproducibility of the marginal and internal adaptations of four-unit fixed partial denture frameworks produced using four CAD/CAM systems. Materials and Methods: Prepared dies of a master model that simulated the loss of the first left molar were measured. Fifteen frameworks were manufactured using four CAD/CAM systems (A–D). The internal fit was determined by the replica technique, and the marginal gap was determined by microscopy. ANOVA was carried out to detect significant differences, and the Bonferron…

Nanoparticulate Systems for Drug Delivery and Targeting to the Central Nervous System

2010

Brain delivery is one of the major challenges for the neuropharmaceutical industry since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the central nervous system (CNS) because of the existence of a physiological low permeable barrier, the blood-brain barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. Many recent data demonstrate that drugs could be transported successfully into the brain using colloidal systems after i.v. injection by several mechanisms such as endocytosis or P-glycoprotei…

High opiate receptor binding potential in the human lateral pain system: A (FEDPN)PET study

2007

IGISOL control system modernization

2016

Abstract Since 2010, the IGISOL research facility at the Accelerator laboratory of the University of Jyvaskyla has gone through major changes. Comparing the new IGISOL4 facility to the former IGISOL3 setup, the size of the facility has more than doubled, the length of the ion transport line has grown to about 50 m with several measurement setups and extension capabilities, and the accelerated ions can be fed to the facility from two different cyclotrons. The facility has evolved to a system comprising hundreds of manual, pneumatic and electronic devices. These changes have prompted the need to modernize also the facility control system taking care of monitoring and transporting the ion beam…

PPAR-γ Agonist GW1929 But Not Antagonist GW9662 Reduces TBBPA-Induced Neurotoxicity in Primary Neocortical Cells

2013

Tetrabromobisphenol A (2,2-bis(4-hydroxy-3,5-dibromophenyl)propane; TBBPA) is a widely used brominated flame retardant. TBBPA induces neuronal damage, but the mechanism by which this occurs is largely unknown. We studied the possible involvement of peroxisome proliferator-activated receptor gamma (PPAR-γ) in TBBPA-induced apoptosis and toxicity in mouse primary neuronal cell cultures. TBBPA enhanced both, caspase-3 activity and lactate dehydrogenase (LDH) release in neocortical cells after 6 and 24 h of exposition. These data were supported at the cellular level with Hoechst 33342 staining. Immunoblot analyses showed that, compared with control cells, 10 μM TBBPA decreased the expression of…

QRAR models for central nervous system drugs using biopartitioning micellar chromatography.

2002

The capability of biopartitioning Micellar Chromatography, BMC, to describe and estimate pharmacokinetic and pharmacodynamic parameters of central nervous system drugs is reviewed in this article. BMC is a mode of micellar liquid chromatography, MLC, that uses micellar mobile phases of Brij35 (polyoxyethilene(23) lauryl ether) prepared in physiological conditions (pH, ionic strength). The retention of a drug in this system depends on its hydrophobic, electronic and steric properties, which also determine its biological activity. The results of BMC studies suggest that this in vitro approach is an attractive useful tool to be implemented into the lead optimization step of drug development sc…

Analysis of oscillations in discontinuous Lurie systems via LPRS method

2019

We discuss advantages and limitations of the harmonic balance method and the locus of a perturbed relay system (LPRS) method in the problem of finding periodic oscillations. In this paper we present the results of using harmonic balance method and LPRS method while investigating a 3rd order dynamic system in Lurie form. In this system a symmetric periodic oscillation is found, while other two asymmetric periodic motions are not found using both methods.

Anomalous thermalization of nonlinear wave systems

2010

We report theoretically and experimentally in an optical system a process of anomalous thermalization of one-dimensional nonlinear Hamiltonian waves. It is characterized by an irreversible evolution of the waves towards a specific equilibrium state of a fundamental different nature than the expected thermodynamic equilibrium state. A kinetic approach of the problem reveals that this phenomenon is due to the existence of a local invariant in frequency space. A novel family of equilibrium distributions is discovered, which is found in quantitative agreement with the numerical simulations.

Inferring species interactions from ecological survey data: a mechanistic approach to predict quantitative food webs of seed-feeding by carabid beetl…

2020

AbstractEcological networks are valuable for ecosystem analysis but their use is often limited by a lack of data because many types of ecological interaction, e.g. predation, are short-lived and difficult to observe or detect. There are different methods for inferring the presence of interactions, which we lack methods to predict interaction strengths and so use weighted network analysis.Here, we develop a trait-based approach suitable for creating quantitative networks, i.e. with varying interaction strengths. We developed the method for seed-feeding carabid ground beetles (Coleoptera: Carabidae) although the principles can be applied to other interactions.We used existing literature data …