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RESEARCH PRODUCT
QRAR models for central nervous system drugs using biopartitioning micellar chromatography.
Yolanda Martín-bioscaSalvador SagradoC. Quiñones‐torreloJ.j. Martínez-plaRosa María Villanueva-camañasM.j. Medina-hernándezsubject
PharmacologyDrugChromatographyChemistrymedia_common.quotation_subjecttechnology industry and agricultureQuantitative Structure-Activity Relationshipmacromolecular substancesGeneral Medicinemusculoskeletal systemModels BiologicalPharmacokineticsDrug developmentIonic strengthMicellar liquid chromatographyDrug DiscoveryAnimalsHumansmedia_commonCentral Nervous System AgentsChromatography Micellar Electrokinetic Capillarydescription
The capability of biopartitioning Micellar Chromatography, BMC, to describe and estimate pharmacokinetic and pharmacodynamic parameters of central nervous system drugs is reviewed in this article. BMC is a mode of micellar liquid chromatography, MLC, that uses micellar mobile phases of Brij35 (polyoxyethilene(23) lauryl ether) prepared in physiological conditions (pH, ionic strength). The retention of a drug in this system depends on its hydrophobic, electronic and steric properties, which also determine its biological activity. The results of BMC studies suggest that this in vitro approach is an attractive useful tool to be implemented into the lead optimization step of drug development scheme.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-10-09 | Mini reviews in medicinal chemistry |