Search results for "Systemic."
showing 10 items of 756 documents
Using discourse segmentation to account for the polyfunctionality of discourse markers:The case of well
2021
Abstract A large number of studies describe the many different functions of polyfunctional discourse markers like well in different contexts and from different theoretical perspectives. In the current paper, we propose to systematize the many different uses identified based on their position with respect to the discourse units they are associated with. Not only can previous findings on well be integrated into a single coherent representation of its uses and functions, but the positions with respect to the discourse units can also be associated with specific functions, thus shedding light on how the polyfunctionality of well is brought about.
Representation and factorization theorems for almost-Lp-spaces
2019
The first and fourth authors gratefully acknowledge the support of Ministerio de Ciencia, Innovacibn y Universidades (Spain), Agencia Estatal de Investigaciones, and FEDER, under projects MTM2014-53009-P (J.M. Calabuig) and MTM2016-77054-C2-1-P (E.A. Sanchez Perez).
In vitro activity of fluconazole, voriconazole and caspofungin against clinical yeast isolates.
2007
Predicting the clinical outcome of a systemic mycosis is often a difficult task, especially when microbiological resistance is one of the factors contributing to therapeutic failure. Some of these factors are host-related--e.g. immune state, site and severity of infection, poor compliance to therapy--while others are associated with the drug's characteristics--e.g. dosage, type of compound (fungistatic/fungicidal), pharmacokinetic properties and drug-drug interactions. In the last few years, clinicians have been confronted with the problem of selecting the most appropriate antifungal therapy for systemic infections and have highlighted the need for a reliable method to assay the in vitro su…
5-Fluorouracil Buccal Tablets for Locoregional Chemotherapy of Oral Squamous Cell Carcinoma: Formulation, Drug Release and Histological Effects on Re…
2010
5-Fluorouracil (5-FU) is currently used for treatment of oral squamous cell carcinoma (OSCC). 5-FU is given by i.v. although the systemic administration is associated with severe toxic effects and no topical formulations of 5-FU for buccal drug delivery have been reported. In this study we would report the development of buccal tablets suitable for direct application of low-doses of 5-FU on cancer lesions. The topical administration could be effective on tumor area while systemic undesired side effects are avoided. Preliminarily, the limited tendency of 5-FU to cross the buccal tissue was established using reconstituted human oral epithelium (RHOE, in vitro) and porcine buccal mucosa (ex vi…
In situ delivery of corticosteroids for treatment of oral diseases.
2017
In many mucocutaneous disorders, corticosteroids therapy is currently central. Systemic therapy is restricted to severe disorders whereas topical applications are considered as the first-line treatment. The oral cavity environment, the medication form and other factors related to the delivery method are key factors for the therapy efficiency and effectiveness. Current marketed medications are not able to avoid wrong drug exposure and scarce patients’ compliance. Innovative in situ delivery systems are able to prolong the drug retention time on the mucosa and to avoid the drawbacks of conventional formulations. This review is intended to give a general overview of oral mucocutaneous patholo…
Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19
2020
Our coalition of public health experts, doctors, and scientists worldwide want to draw attention to the need for high-quality evaluation protocols of the potential beneficial effect of hydroxychloroquine (HCQ) as a post-exposure drug for exposed people. In the absence of an approved, recognized effective pre or post-exposure prophylactic drug or vaccine for COVID-19, nor of any approved and validated therapeutic drug, coupled with social and political pressure raised by publicity both regarding the potential beneficial effect of hydroxychloroquine (HCQ) as well as potential risks from HCQ, we urge the immediate proper clinical trials. Specifically, we mean using HCQ for post-exposure of peo…
Drug-Induced Respiratory Disease in Connective Tissue Diseases
2004
Publisher Summary This chapter discusses drug-induced respiratory disease in connective tissue diseases. Drug-induced lung diseases (DILDs) vary in severity from mild to life threatening. Generally, DILDs subside upon drug discontinuance, and leave permanent sequelae in a minority of patients. Less frequently, DILDs persist unabated, or progress despite drug withdrawal, requiring specific management. Drugs used in connective tissue diseases (CTDs) can produce a constellation of pulmonary and systemic reactions. These can mimic pulmonary involvement from CTD, a systemic disease, or an infection, and are difficult to prevent, predict, and diagnose. Maintaining a high index of suspicion enable…
The Case Law of the ECtHR in 2020 in the Light of the Principle of Systemic Harmonisation
2021
This article provides for an overview of some relevant developments in the case-law of the ECtHR in 2020. Priority will be given to Grand Chamber judgments and decisions and those of the Chambers deemed to be relevant from a substantial and procedural viewpoint. Given that in 2020 the Steering Committee for Human Rights published its report on ‘The Place of the European Convention of Human Rights in the International and European Legal Order’, the case-law will be selected and examined from the viewpoint of the principle of systemic harmonisation. The aim is highlighting positive and negative examples of application of general international law by the ECtHR, of cross-fertilisation between t…
Special issue of Quantitative Finance on ‘Interlinkages and Systemic Risk’
2015
This special issue of Quantitative Finance collects eight papers on the relation between interlinkages and systemic risk. The papers cover several types of interlinkages and follow different approaches, from agent-based modelling to empirical investigation of large and sometimes confidential data. The special issue collects some of the contributions presented at the international workshop‘Interlinkages and systemic risk ’ , which took place in Ancona (Italy) on 4 – 5 July 2013. The workshop, organized within the research project‘. New tools in the credit network modeling with agents ’ heterogeneity ’ funded by the Institute for New Economic Thinking, was attended by a balanced mix of schola…
A machine learning application to predict early lung involvement in scleroderma: A feasibility evaluation
2021
Introduction: Systemic sclerosis (SSc) is a systemic immune-mediated disease, featuring fibrosis of the skin and organs, and has the greatest mortality among rheumatic diseases. The nervous system involvement has recently been demonstrated, although actual lung involvement is considered the leading cause of death in SSc and, therefore, should be diagnosed early. Pulmonary function tests are not sensitive enough to be used for screening purposes, thus they should be flanked by other clinical examinations