Search results for "T reg"
showing 10 items of 208 documents
Power Bus Management Techniques for Space Missions in Low Earth Orbit
2021
In space vehicles, the typical configurations for the Solar Array Power Regulators in charge of managing power transfer from the solar array to the power bus are quite different from the corresponding devices in use for terrestrial applications. A thorough analysis is reported for the most popular approaches, namely Sequential Switching Shunt Regulation and parallel-input Pulse Width Modulated converters with Maximum Power Point Tracking. Their performance is compared with reference to a typical mission in low Earth orbit, highlighting the respective strengths and weaknesses. A novel solar array managing technique, the Sequential Maximum Power Tracking, is also introduced in the trade-off a…
Análisis de métodos de validación cruzada para la obtención robusta de parámetros biofísicos
2015
[EN] Non-parametric regression methods are powerful statistical methods to retrieve biophysical parameters from remote sensing measurements. However, their performance can be affected by what has been presented during the training phase. To ensure robust retrievals, various cross-validation sub-sampling methods are often used, which allow to evaluate the model with subsets of the field dataset. Here, two types of cross-validation techniques were analyzed in the development of non-parametric regression models: hold-out and k-fold. Selected non-parametric linear regression methods were least squares Linear Regression (LR) and Partial Least Squares Regression (PLSR), and nonlinear methods were…
Changes in telepsychiatry regulations during the COVID-19 pandemic: 17 countries and regions' approaches to an evolving healthcare landscape
2020
Author(s): Kinoshita, Shotaro; Cortright, Kelley; Crawford, Allison; Mizuno, Yuya; Yoshida, Kazunari; Hilty, Donald; Guinart, Daniel; Torous, John; Correll, Christoph U; Castle, David J; Rocha, Deyvis; Yang, Yuan; Xiang, Yu-Tao; Kolbaek, Pernille; Dines, David; ElShami, Mohammad; Jain, Prakhar; Kallivayalil, Roy; Solmi, Marco; Favaro, Angela; Veronese, Nicola; Seedat, Soraya; Shin, Sangho; Salazar de Pablo, Gonzalo; Chang, Chun-Hung; Su, Kuan-Pin; Karas, Hakan; Kane, John M; Yellowlees, Peter; Kishimoto, Taishiro | Abstract: BackgroundDuring the COVID-19 pandemic, the use of telemedicine as a way to reduce COVID-19 infections was noted and consequently deregulated. However, the degree of te…
Tutela e sicurezza del lavoro tra centro e periferia: la sicurezza sui luoghi di lavoro
2013
Il saggio prende in esame la complessa questione del riparto di competenze tra Stato e Regioni alla luce del Titolo V della Costituzione in materia di salute e sicurezza sui luoghi di lavoro. Il riparto di competenze tra centro e periferia è stato oggetto di una limitata analisi da parte della dottrina e della giurisprudenza, che si sono concentrate in particolare sulla disciplina del mercato del lavoro. L’Autore descrive un sistema multilivello, caratterizzato dalla compresenza di fonti nazionali e regionali, della contrattazione collettiva, nonché di codici di condotta. Sulla scorta di una ricostruzione del quadro normativo e dei percorsi della giurisprudenza, il saggio propone una lettur…
Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector
2008
An ideal gene therapy vector should enable persistent transgene expression without limitations of safety and reproducibility. Here we report the development of a non-viral episomal plasmid DNA (pDNA) vector that appears to fulfil these criteria. This pDNA vector combines a scaffold/matrix attachment region (S/MAR) with a human liver-specific promoter (alpha1-antitrypsin (AAT)) in such a way that long-term expression is enabled in murine liver following hydrodynamic injection. Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in situ bioluminescent imaging. All relevant control pDNA constructs expressing luciferas…
Analysing the Spanish smoke-free legislation of 2006: a new method to quantify its impact using a dynamic model.
2011
Background: There are many models that study aspects of smoking habits: the influence of price, tax, relapse time, and the effects of prohibition. There are also studies examining the effects of the Spanish smoke-free law. We wanted to build a model able to separate the effect of the law from the pre-law evolution of smoking habits. Methods: Using data from the Spanish Ministry of Health and Social Policy, we developed a dynamic model of tobacco use. The model projects the evolution over time of the number of non-smokers, smokers and ex-smokers before 2006. Then, we compared the predictions of the model with data for the years after the law came into force, 2006 and 2009. Results: We show t…
Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver.
2010
We have previously described the development of a scaffold/matrix attachment region (S/MAR) episomal vector system for in vivo application and demonstrated its utility to sustain transgene expression in the mouse liver for at least 6 months following a single administration. Subsequently, we observed that transgene expression is sustained for the lifetime of the animal. The level of expression, however, does drop appreciably over time. We hypothesised that by eliminating the bacterial components in our vectors, we could improve their performance since bacterial sequences have been shown to be responsible for the immunotoxicity of the vector and the silencing of its expression when applied i…
Decremento delle cellule T regolatorie (Treg) CD4+CD25+FOXP3+ nei linfociti periferici dei pazienti affetti da diabete di tipo 1.
2006
Distinct subsets of intrathyroidal regulatory CD4+CD25+ and CD8+CD25+ T cells in Hashimoto's thyroiditis: Potential role in the neoplastic cell growt…
2005
Terrorism as a threat to international tourism: world trends
2018
Current world trends in the development of tourism industry are studied in the article. The essence and types of terrorism have been determined; their classification has been provided. The influence of terrorist acts on the development of tourism in different regions has been analyzed. The efforts made by the international community to neutralize this new challenge for the tourism business have been examined.