Search results for "T1"

showing 10 items of 587 documents

An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

2008

Abstract Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy–based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutations and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in vitro and on outcome after adjuvant tamoxifen. PIK3CA mutations were more common in hormone receptor–positive (34.5%) and HER2-positive (22.7%) than in basal-like tumors (8.3%). AKT1 (1.4%) and PTEN (2.3%) mutations were restricted to hormone receptor–positive cancers. Unlike AKT1 mutations that were absent …

ProteomicsCancer ResearchClass I Phosphatidylinositol 3-KinasesAKT1Breast NeoplasmsBiologymedicine.disease_causeArticlePhosphatidylinositol 3-KinasesBreast cancermedicineHumansPTENneoplasmsProtein kinase BPI3K/AKT/mTOR pathwayMutationPTEN PhosphohydrolaseCancerGenomicsmedicine.diseaseOncologyMutationCancer researchbiology.proteinFemaleProto-Oncogene Proteins c-aktCell DivisionTamoxifenmedicine.drugCancer Research
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SIK2 orchestrates actin-dependent host response upon Salmonella infection

2021

Significance Through conducting quantitative proteomics upon Salmonella infection, we identified a SIK2 signaling network, implementing the kinase into a so far concealed biological function. Our data exposed SIK2 as a central orchestrator of an actin regulatory network, coordinating the stability of Salmonella-containing vacuole (SCV) and cellular actin assembly, in order to limit the acute phase of the infection. Most strikingly, SIK2 is not exclusively acting locally on actin assembly associated with the SCV but impacts the actin cytoskeleton architecture in its entirety upon Salmonella infection. Our work provides a mechanistic framework for how the actin cytoskeleton is regulated and h…

ProteomicsSalmonellaactin cytoskeletonImmunoblottingArp2/3 complexSalmonella infectionmacromolecular substancesProtein Serine-Threonine Kinasesmedicine.disease_causeBiochemistry03 medical and health sciencesMice0302 clinical medicineSalmonellamedicineXenophagyAnimalsHumansArp2/3 complexProtein Interaction MapsPhosphorylationActinCells Cultured030304 developmental biologyActin nucleation0303 health sciencesMultidisciplinarybiologyEpithelial CellsBiological Sciencesmedicine.diseaseActin cytoskeletonHCT116 CellsPhosphoproteinsActinsCell biologySalmonella-containing vacuoleHEK293 CellsFormins407Host-Pathogen Interactionsbiology.proteinRNA Interference030217 neurology & neurosurgeryhost–pathogen interactionsHeLa CellsSignal TransductionProceedings of the National Academy of Sciences of the United States of America
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Enablers of the successful implementation of simulation exercises: a qualitative study among nurse teachers in undergraduate nursing education

2021

Abstract Background Simulation exercises are increasingly being used as a teaching method in the field of undergraduate nursing education. Thus, the present study sought to identify, describe and discuss enablers of the successful implementation of simulation exercises in undergraduate nursing education. Methods This study had a qualitative descriptive design and involved individual interviews conducted between November and December 2018 with six nurse teachers from three different university campuses in Norway. The transcribed interviews were analysed by means of a qualitative thematic analysis. Results The majority of the interviewees wanted to offer more simulation exercises as part of t…

Protocol (science)Clinical deteriorationUndergraduate nursingbusiness.industryResearchTeaching methodNursing researcheducationRT1-120NursingVDP::Medisinske Fag: 700::Helsefag: 800NursingTeaching methodComputingMilieux_COMPUTERSANDEDUCATIONSimulation trainingMedicineInterviewNurse educationNursing educationThematic analysisbusinessNursing managementGeneral NursingQualitative researchBMC Nursing
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The state of the nursing science in Spain

2002

This article is giving a historical perspective of the nursing science in Spain, comparing it with the situation of the science, and nursing science at international level. The author gave a very clear description of the state of the art, and the nursing outcome shared by Spanish authors with the rest of nursing scientific community, arriving to the conclusion that Spanish nursing is at the beginning of a process where, negative factors can be clearly identified and, potential measures to improve relatively easily nursing science can be taken in the short term.

Publishinglcsh:RT1-120Nursing Researchknowledgeresearchnursinglcsh:NursingSpainLegislation NursingGeneral NursingRevista Latino-Americana de Enfermagem
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Hierarchical Syntactic Models for Human Activity Recognition through Mobility Traces

2019

AbstractRecognizing users’ daily life activities without disrupting their lifestyle is a key functionality to enable a broad variety of advanced services for a Smart City, from energy-efficient management of urban spaces to mobility optimization. In this paper, we propose a novel method for human activity recognition from a collection of outdoor mobility traces acquired through wearable devices. Our method exploits the regularities naturally present in human mobility patterns to construct syntactic models in the form of finite state automata, thanks to an approach known asgrammatical inference. We also introduce a measure ofsimilaritythat accounts for the intrinsic hierarchical nature of su…

QA75Computer science02 engineering and technologyManagement Science and Operations ResearchSimilarity measureMachine learningcomputer.software_genreZA4050Set (abstract data type)Activity recognitionGrammatical inference Human activity recognition Mobility020204 information systemsSmart citySimilarity (psychology)0202 electrical engineering electronic engineering information engineeringSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniFinite-state machineT1business.industryGrammar inductionComputer Science ApplicationsHardware and Architecture020201 artificial intelligence & image processingArtificial intelligenceGranularitybusinesscomputer
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Continuous Analysis of Running Mechanics by Means of an Integrated INS/GPS Device

2019

This paper describes a single body-mounted sensor that integrates accelerometers, gyroscopes, compasses, barometers, a GPS receiver, and a methodology to process the data for biomechanical studies. The sensor and its data processing system can accurately compute the speed, acceleration, angular velocity, and angular orientation at an output rate of 400 Hz and has the ability to collect large volumes of ecologically-valid data. The system also segments steps and computes metrics for each step. We analyzed the sensitivity of these metrics to changing the start time of the gait cycle. Along with traditional metrics, such as cadence, speed, step length, and vertical oscillation, this system est…

QA75GV557_SportsT1neuroverkotlcsh:Chemical technologyneural networksArticlejuoksumachine learningkoneoppiminenmittauslaitteetsatelliittipaikannusMachine learninggait analysislcsh:TP1-1185sports equipmentbiomekaniikkaINS/GPSvelocity measurement
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
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Como as práticas ecológicas e o desperdício de alimentos influenciam o capital de marca do restaurante?

2020

Resumen El presente trabajo tuvo por objetivo evaluar la incidencia de las prácticas verdes, la innovación sostenible y el manejo del desperdicio alimentario en la construcción del capital de marca de los restaurantes. A partir de una investigación cuantitativa dirigida a responsables de restaurantes en Ecuador, se obtuvieron 120 cuestionarios válidos que permitieron estimar un modelo de ecuaciones estructurales a través de la regresión de mínimos cuadrados parciales. Los resultados obtenidos evidencian que las prácticas verdes orientadas a la formación del empleado y la innovación sostenible contribuyen significativamente a la reducción del desperdicio alimentario, que, a su vez, junto a l…

Residuos alimentariosRestaurantsStrategy and ManagementRestaurantesConsumidoresServices//vocabularies.unesco.org/thesaurus/concept1545 [http]PercepciónResources managementCapital de marca//vocabularies.unesco.org/thesaurus/concept10043 [http]Tratamiento de desechos//vocabularies.unesco.org/thesaurus/concept6382 [http]Management of Technology and Innovation//id.loc.gov/authorities/subjects/sh00005605 [http]waste recyclingConsumo alimentarioMercadoSupply and demandWastesMarketingM31 Marketing//id.loc.gov/authorities/subjects/sh85099708 [http]//id.loc.gov/authorities/subjects/sh2011004561 [http]Tratamiento de desperdiciosmanejo del desperdicio alimentarioConsumo de alimentos//id.loc.gov/authorities/subjects/sh85031491 [http]sustainable innovation//id.loc.gov/authorities/subjects/sh85050268 [http]SostenibilidadResiduos de alimentosWaste treatmentQ56 Sustainabilitycapital de marcaSustainabilityConsumo alimenticio//id.loc.gov/authorities/subjects/sh85113249 [http]sustentabilidadeMarketsgreen practicesEconomics and Econometrics//vocabularies.unesco.org/thesaurus/concept1833 [http]Organic wastesTratamiento de residuosServiciossostenibilidadlcsh:BusinessL83 RestaurantsManejo del desperdicio alimentarioInnovación sostenible//vocabularies.unesco.org/thesaurus/concept6436 [http]innovación sosteniblefood waste managementdesperdício de alimentosDesechosPrácticas verdesFood consumptionBusiness and International Management//id.loc.gov/authorities/subjects/sh2009000375 [http]//vocabularies.unesco.org/thesaurus/mt6.65 [http]Desperdicio alimentarioOferta y demandaFood wasteReciclaje de desperdiciosbrand equityResiduos orgánicospráticas verdesGestión de recursosDesperdiciorestaurantesinovação sustentávelWaste//vocabularies.unesco.org/thesaurus/concept15060 [http]PerceptionConsumersprácticas verdeslcsh:HF5001-6182//vocabularies.unesco.org/thesaurus/concept4056 [http]Finance
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Efeitos da sustentabilidade e valor logístico nas relações entre empresas de transporte marítimo

2020

Resumen El objetivo de este trabajo fue analizar cómo la sostenibilidad (económica, social y ambiental), bajo el enfoque de triple línea base, afecta la calidad de servicio, el valor logístico y la satisfacción en empresas del sector marítimo. Se propone un modelo teórico que se contrasta con la información suministrada por una muestra de 50 responsables de empresas (transitarios, importadores y exportadores) en Panamá. La información se analiza mediante la estimación de regresión por mínimos cuadrados parciales, que permite confirmar el carácter multidimensional de la sostenibilidad y del valor logístico. Los resultados también confirman que las percepciones de los clientes sobre las inici…

Responsabilidad social empresarialrelaciones business to businessEconomicsStrategy and Management//vocabularies.unesco.org/thesaurus/concept585 [http]Calidad de servicioRelaciones business to businessSatisfactionInternational tradeSocial responsibilityshipping industry//id.loc.gov/authorities/subjects/sh87004890 [http]Crecimiento económicoEmbarque de mercancíaspráticas sustentáveisCompañías de navegaciónindústria marítimaComercio internacionalManagement of Technology and InnovationShipment of goods//vocabularies.unesco.org/thesaurus/concept16052 [http]//vocabularies.unesco.org/thesaurus/concept3534 [http]logistic valueMarketing//id.loc.gov/authorities/subjects/sh85081260 [http]//id.loc.gov/authorities/subjects/sh85127728 [http]Responsabilidad socialCommerce internationalPrácticas sosteniblesMarine resources conservationSostenibilidadqualidade de serviçoQ56 SustainabilitySustainabilitybusiness-to-business relationships//vocabularies.unesco.org/thesaurus/concept6828 [http]Transporte marítimosustainable practicesEmploymentEconomics and Econometricsdemand supply and congestion [R41 Transportation]//id.loc.gov/authorities/subjects/sh85121576 [http]Steamboat linesConservación de los recursos marinos//id.loc.gov/authorities/subjects/sh85121579 [http]lcsh:Businessvalor logísticoindustria marítima//vocabularies.unesco.org/thesaurus/concept11744 [http]EconomíaShippingComercio exteriorSatisfacciónTransporte acuáticoBusiness and International Management//id.loc.gov/authorities/subjects/sh2009000375 [http]Economic growth//vocabularies.unesco.org/thesaurus/concept682 [http]calidad de servicioEconómicasprácticas sosteniblesIndustria marítimarelações business to businessSocial responsibility of business//id.loc.gov/authorities/subjects/sh85040850 [http]Maritime transport//id.loc.gov/authorities/subjects/sh85020473 [http]quality of service//id.loc.gov/authorities/subjects/sh85117681 [http]CarriersValor logísticolcsh:HF5001-6182Empresas de transporteEmpleoFinance
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The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.

2012

The ascending midbrain 5-HT neurons to the forebrain may be dysregulated in depression and have a reduced trophic support. Within situproximity ligation assay (PLA) and supported by coimmunoprecipitation and colocation of the FGFR1 and 5-HT1A immunoreactivities in the midbrain raphe cells, evidence for the existence of FGFR1–5-HT1A receptor heterocomplexes in the dorsal and median raphe nuclei of the Sprague Dawley rat as well as in the rat medullary raphe RN33B cells has been obtained. Especially after combined FGF-2 and 8-OH-DPAT treatment, a marked and significant increase in PLA clusters was found in the RN33B cells. Similar results were reached with the FRET technique in HEK293T cells,…

Retractedmedicine.medical_specialtySerotonin receptorsEncèfalSettore BIO/11 - Biologia MolecolareBiologySettore BIO/09 - FisiologiaReceptors de serotoninaMidbrainInternal medicineRatesmedicineReceptor5-HT receptorNeuronal Plasticity Receptor Fibroblast Growth Factor Receptor Serotonin 5-HT1A Serotonergic Neurons SerotoninRapheGeneral NeuroscienceEncephalonFibroblastsRatsEndocrinologymedicine.anatomical_structurenervous systemForebrainAutoreceptor5-HT1A receptorNeuron
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