Search results for "T1"
showing 10 items of 587 documents
Addition of NMDA-receptor antagonist MK801 during oxygen/glucose deprivation moderately attenuates the upregulation of glucose uptake after subsequen…
2011
During stroke the blood–brain barrier (BBB) is damaged which can result in vasogenic brain edema and inflammation. The reduced blood supply leads to decreased delivery of oxygen and glucose to affected areas of the brain. Oxygen and glucose deprivation (OGD) can cause upregulation of glucose uptake of brain endothelial cells. In this letter, we investigated the influence of MK801, a non-competitive inhibitor of the NMDA-receptor, on the regulation of the glucose uptake and of the main glucose transporters glut1 and sglt1 in murine BBB cell line cerebEND during OGD. mRNA expression of glut1 was upregulated 68.7- fold after 6 h OGD, which was significantly reduced by 10 μM MK801 to 28.9-fold.…
Focal liver lesions hyperintense on T1-weighted magnetic resonance images.
2009
This article reviews focal liver lesions hyperintense on T1-weighted magnetic resonance (MR) images and describes the underlying etiologies associated with their T1 signal intensity. Although focal liver lesions are commonly detected because of their iso- or hypointensity on T1-weighted images, lesions (benign or malignant) may present with T1 hyperintensity when they contain T1 shortening elements--such as fat, hemorrhage, copper, melanin, and highly concentrated proteins. Our discussion includes the description of state-of-the-art T1-weighted MR sequences and the imaging features of lesions on pre- and postcontrast MR images that are characteristic for lesion composition and useful for ma…
Materiell og profesjonell stigmatisering av mennesker med sykelig overvekt
2017
The aim of this study is to show how people suffering from severe obesity mightexperience stigmatization. We interviewed 6 persons recruited from aNorwegian rehabilitation center, specialized in lifestyle intervention in severeobesity. We found that the participants suffering from severe obese experiencedstigmatization and thus felt that they a) did not fit into the materiel world and b)experienced a lack of respect from health care professionals. The results arediscussed according to how contemporary symbols are embedded in oursurroundings and in our bodies. The conclusion underlines severe obesity as acomplex problem which is strengthened by rooms and interior designed for idealsizes. The…
IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
2007
IL-27 is an IL-12-related cytokine frequently present at sites of inflammation that can promote both anti- and pro-inflammatory immune responses. Here, we have analyzed the mechanisms how IL-27 may drive such divergent immune responses. While IL-27 suppressed the development of proinflammatory Th17 cells, a novel role for this cytokine in inhibiting the development of anti-inflammatory, inducible regulatory T cells (iTreg) was identified. In fact, IL-27 suppressed the development of adaptive, TGF-beta-induced Forkhead box transcription factor p3-positive (Foxp3(+)) Treg. Whereas the blockade of Th17 development was dependent on the transcription factor STAT1, the suppression of iTreg develo…
Implicación de los microARNs en la hipertensión pulmonar idiopática. Regulación farmacológica
2014
La hipertensión pulmonar (HP) es un desorden complejo que se caracteriza por un aumento progresivo de la presión arterial pulmonar, ocasionado por el remodelado de las arterias pulmonares de pequeño calibre, que origina un aumento de resistencias pulmonares y como consecuencia sobrecarga y fallo del ventrículo derecho que puede llevar al fallecimiento del paciente. La Organización mundial de la salud la clasifica en 5 grupos, en nuestro estudio nos hemos centrado en el grupo I, que se caracteriza por la afección de los vasos pulmonares de pequeño calibre, con una presión arterial pulmonar (PAP) media de ≥ 25 mmHg y ausencia de causas secundarias, este así mismo se subdivide en hipertensión …
Fysioterapeuters erfaringer med bruk av fysisk aktivitet til eldre deprimerte
2015
This article is based upon a study of the experiences of physiotherapists working with elderly depressed patients and the use of physical activity. Depression in the elderly is a common condition, and it is estimated to be the second most common cause of failing health towards 2020. Physical activity has a positive effect on depression in the elderly. The aim of this study was to investigate the experiences of physiotherapist`s in the treatment of elderly depressed patients over 65 years of age. Data was collected by qualitative reasearch interviews of 5 physiotherapists. Important findings of this study were that the physiotherapists experienced that they did not get any referrals to treat…
Helsepersonells erfaringer og tanker om bruk av frivillige i palliativ omsorg
2017
Health care personnel’s experiences and thoughts on the use of volunteers in palliative care in a social perspectiveThe government of Norway is planning for the municipalities’ health care resources, including volunteering. The purpose of this study was to shed light on the experiences and thoughts of a group of health care personnel on the use of volunteers in palliative care in the community health care services, and to discuss the findings in a social perspective. Individual interviews were conducted with seven nurses and three nursing assistants. Using a qualitative content analysis three categories emerged: "The importance of organization, clarification and responsibility," "Qualificat…
Pirmā tipa cukura diabēta pacientu fiziskās aktivitātes līmeņa ietekme uz depresijas simptomiem
2021
Maģistra darba mērķis - Noskaidrot CD 1 pacientu fiziskās aktivitātes līmeņa asociāciju ar depresijas simptomiem. Pētījuma hipotēze - Fiziski aktīviem CD1 pacientiem ir zemāks depresijas pazīmju līmenis. Uzdevumi: 1.Noskaidrot CD 1 pacientu fiziskās aktivitātes līmeni; 2.Noskaidrot vai fiziskā aktivitāte un tās intensitāte ir saistīta ar depresijas simptomiem pacientiem ar CD 1; 3.Noskaidrot kādi faktori ir asociēti ar CD 1 pacientu depresijas simptomu attīstību; 4.Noskaidrot kādi faktori ir asociēti ar CD 1 pacientu fizisko aktivitāti. Pētījumā dizains - šķērsgriezuma pētījums ar sekundāro datu apstrādi. Iegūtie dati tika analizēti – ar SPSS, Excel, Word process. Pētījumā piedalījās 346 pa…
Libertad religiosa y matrimonio
2019
Nuestra sociedad se caracteriza por ser globalizada, plural y diversa. Ello ha tenido su reflejo en los modelos de celebración del matrimonio que reconoce nuestro ordenamiento, siendo opcional para los contrayentes la elección de su modelo: matrimonio civil regulado por el Código civil, ya sea en forma civil o en las formas religiosas de las confesiones con acuerdo o con notorio arraigo, y el matrimonio canónico. Tomando como punto de partida el marco normativo, el trabajo explica los diversos modelos y la eficacia civil de los matrimonios religiosos. Seguidamente, analiza los desafíos que plantea a nuestra sociedad y derecho algunas cuestiones, como los matrimonios interculturales o interr…
Stress induced premature liver senecence in adulthood after transient postnatal overfeeding in mice
2017
IF 2.043; International audience