Search results for "TACs"

showing 10 items of 12 documents

Brain Oscillatory and Hemodynamic Activity in a Bimanual Coordination Task Following Transcranial Alternating Current Stimulation (tACS): A Combined …

2018

Motor control is associated with synchronized oscillatory activity at alpha (8–12 Hz) and beta (12–30 Hz) frequencies in a cerebello-thalamo-cortical network. Previous studies demonstrated that transcranial alternating current stimulation (tACS) is capable of entraining ongoing oscillatory activity while also modulating motor control. However, the modulatory effects of tACS on both motor control and its underlying electro- and neurophysiological mechanisms remain ambiguous. Thus, the purpose of this study was to contribute to gathering neurophysiological knowledge regarding tACS effects by investigating the after-effects of 10 Hz tACS and 20 Hz tACS at parietal brain areas on bimanual coord…

Cognitive NeurosciencePosterior parietal cortexElectroencephalographyalpha oscillations050105 experimental psychologybimanual movementslcsh:RC321-57103 medical and health sciencesBehavioral Neuroscience0302 clinical medicineNeuroimagingmedicine0501 psychology and cognitive scienceslcsh:Neurosciences. Biological psychiatry. NeuropsychiatryTranscranial alternating current stimulationOriginal Researchbeta oscillationsmedicine.diagnostic_testbusiness.industry05 social sciencesMotor controlhigh-definition tACSNeurophysiologyafter-effectsElectrophysiologystomatognathic diseasesNeuropsychology and Physiological Psychologymedicine.anatomical_structurebusinessNeuroscience030217 neurology & neurosurgeryHboxyMotor cortexNeuroscienceFrontiers in Behavioral Neuroscience
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Advances in contamination risk setting of aquifers: the karst Nebrodi region (Sicily)

2009

GALDITcoastal aquiferSINTACSpollution mitigation
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Application of SINTACS method to the aquifers of Piana di Palermo, Siciliy,Italy

2004

Piana di Palermo is characterized by the presence of two different aquifers: one shallow, constituted by calcarenites and the other deep in fractured carbonates. The calcarenitic aquifer presents a low potential compared to the carbonatic aquifer. The chemistry of the water in both aquifers reflects water-rock interaction, seawater intrusion, ionic exchange etc. The application of SINTACS method showed that about 80% of the study area can be classified as of high to very high vulnerability. Piana di Palermo es caracterizada por la presencia de dos acuíferos diferentes: uno somero constituido por calcarenitas y otro profundo en rocas carbonatadas fracturadas. El acuífero calcarenítico presen…

Hydrogeology Groundwater vulnerability SINTACS Piana di Palermo SicilyHidrogeología vulnerabilidad acuifera SINTACS Piana di Palermo Sicilia
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Diagnosis and therapeutic management of primary headache in an emergency setting

2013

Introduction and aim: Much headachers are under or mis-diagnoses and data regarding the proportion of patients attending an emergency department (ED) because of headache are still few. We conducted a retrospective observational study in an ED with the following aims: (a) estimate the proportion of headache attending to an ED (b) to estimate and describe the therapeutic management of primary headache and (c) to assessment the exam most frequently requested. Materials and methods: We collected data regarding patients diagnosed with headache consecutively attending the ED of the University of Palermo between September 2011 and March 2012. The study was approved by the ethics committee. Results: Between the semester evaluated 25110 subjects were admitted to ED headache suffers were equal to 1.6 %. Of these 263 (63.1 %) were woman and 154 (36.9 %). Mean age was 44.2 (DS ± 18.4) years (p = 0.068).According to ED registry headache admission was as follow assigned: 76.5 % with a diagnosis of headache 22.8 % with a secondary headache 0.7 % with Trigeminal Autonomic Cephalgias (TACs). Among those with a primary headache about 36 % of patient did not received a pharmacological treatment. Monotherapy was prescribed less frequently than combination therapy (19.1 vs 44.5 %).In monotherapy the most frequent medication were NSAIDs (28.3 %) benzodiazepines (26.7 %) and dopamine antagonists (11.7 %). Among those with a primary headache a CT scan was performed in the 124 subjects and 111 (34.8 %) had a neurologist consultation. Discussion: Our data are in line with the one previously reported in literature. The most frequently medication in the Italian ED were NSAIDs benzodiazepines dopamine antagonists and steroids. Neverless our data unlikely can be compared to other study give a snapshot. We believe that much more can be done to improve treatment of primary headache in ED.Settore MED/26 - Neurologia
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Different forms of trigeminal autonomic cephalalgias in the same patient: description of a case.

2010

The trigeminal autonomic cephalalgias (TACs), including cluster headache, paroxysmal hemicrania and SUNCT, are characterized by the cardinal combination of short-lasting unilateral pain and autonomic phenomena affecting the head. Hemicrania continua (HC) shares many clinical characteristics with TACs, including unilateral pain and ipsilateral autonomic features. Nevertheless, HC is separately classified in the revised International Classification of Headache Disorders (ICHD-II). Here, we describe the case of a 45-year-old man presenting an unusual concurrence of different forms of primary headaches associated with autonomic signs, including subsequently ipsilateral cluster headache, SUNCT a…

Malemedicine.medical_specialtyHemicrania continua Cluster headache SUNCTTACsNeurologyCluster headacheClinical NeurologyCase ReportAutonomic Nervous SystemDiagnosis DifferentialSUNCTmedicineHumansParoxysmal HemicraniaTrigeminal NerveTrigeminal nerveSUNCT Syndromebusiness.industryCluster headacheAnti-Inflammatory Agents Non-SteroidalHeadacheHemicrania continuaGeneral MedicineCerebral ArteriesMiddle Agedmedicine.diseaseDermatologyTrigeminal Autonomic CephalalgiasAutonomic nervous systemAnesthesiology and Pain MedicineTreatment OutcomeHemicrania continuaAnesthesiaInternational Classification of Headache DisordersAnticonvulsantsSettore MED/26 - NeurologiaNeurology (clinical)Trigeminal autonomic cephalalgiabusinessTACs
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PROTACs: The Future of Leukemia Therapeutics

2022

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various types of Leukemia/Blood malignancies.

PROTACsleukemiacanceranticancer therapeuticsCell BiologylinkerDevelopmental BiologyFrontiers in Cell and Developmental Biology
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Nuovi contributi alla valutazione del rischio d'inquinamento degli acquiferi nella fascia costiera dell regione carsica nebroidea (Sicilia nord-orien…

2009

SINTACS GALDIT Analisi Statistica Inquinamento Acquiferi
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Effects of low-gamma tACS on primary motor cortex in implicit motor learning

2019

Abstract In the primary motor cortex (M1), rhythmic activity in the gamma frequency band has been found during movement planning, onset and execution. Although the role of high-gamma oscillatory activity in M1 is well established, the contribution of low-gamma activity is still unexplored. In this study, transcranial alternating current stimulation (tACS) was used with the aim to specifically modulate low-gamma frequency band in M1, during an implicit motor learning task. A 40 Hz-tACS was applied over the left M1 while participants performed a serial reaction time task (SRTT) using their right hand. The task required the repetitive execution of sequential movements in response to sequences …

Serial reaction timeAdultMaleComputer scienceMotor learningmedicine.medical_treatmentMovementPrimary motor cortexInterference theoryMotor ActivityTranscranial Direct Current StimulationGamma oscillation03 medical and health sciencesBehavioral Neuroscience0302 clinical medicinemedicineReaction TimeGamma RhythmHumansLearning030304 developmental biologyTranscranial alternating current stimulationMotor Evoked Potentials (MEP)0303 health sciencesSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMotor Cortextranscranial Alternating Current Stimulation (tACS)Evoked Potentials MotorRandom sequenceHealthy VolunteersTranscranial magnetic stimulationSerial reaction time task (SRTT)FemaleSequence learningPrimary motor cortexMotor learningNeuroscience030217 neurology & neurosurgeryPsychomotor Performance
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Functional Role of Cerebellar Gamma Frequency in Motor Sequences Learning: a tACS Study

2021

Although the role of the cerebellum in motor sequences learning is widely established, the specific function of its gamma oscillatory activity still remains unclear. In the present study, gamma (50 Hz)—or delta (1 Hz)—transcranial alternating current stimulation (tACS) was applied to the right cerebellar cortex while participants performed an implicit serial reaction time task (SRTT) with their right hand. The task required the execution of motor sequences simultaneously with the presentation of a series of visual stimuli. The same sequence was repeated across multiple task blocks (from blocks 2 to 5 and from blocks 7 to 8), whereas in other blocks, new/pseudorandom sequences were reproduce…

Serial reaction timeCerebellumVisual perceptionComputer sciencemedicine.medical_treatmentStimulationTranscranial Direct Current Stimulation050105 experimental psychologyTask (project management)03 medical and health sciences0302 clinical medicineImplicit motor learningTranscranial magnetic stimulation (TMS)CerebellummedicineHumans0501 psychology and cognitive sciencesCerebellar stimulation05 social sciencesMotor CortexEvoked Potentials MotorTranscranial Magnetic StimulationTranscranial magnetic stimulationSerial reaction time task (SRTT)medicine.anatomical_structureNeurologyOriginal ArticleTranscranial alternating current stimulation (tACS)Neurology (clinical)Primary motor cortexMotor learningNeurosciencePsychomotor Performance030217 neurology & neurosurgeryThe Cerebellum
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IMAGE PROCESSING IN POLLUTION VULNERABILITY ASSESSMENT OF SICILY AQUIFERS

2009

It is generally acknowledged that vulnerability mapping represents an essential tool for territory management. Intrinsic vulnerability can be generally described as “the susceptibility of the aquifer systems, in their different components and in different geometric and hydrodynamics situations, to swallow and diffuse, also mitigating the effects, a fluid or water-transported pollutant, in such a way to produce impact on the groundwater quality, in space and time”. Assessment procedures of vulnerability consider a number of parameters, the estimation of which is usually difficult and very often insufficient to correctly represent aquifer’s features. As aquifers are closely influenced by nume…

VulnerabilityAquiferSicilySINTACSMatrix correlation.
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