Search results for "TAM"
showing 10 items of 11664 documents
Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains
2021
Over the past few decades, extensively drug resistant (XDR) resistant Klebsiella pneumoniae has become a notable burden to healthcare all over the world. Especially carbapenemase-producing strains are problematic due to their capability to withstand even last resort antibiotics. Some sequence types (STs) of K. pneumoniae are significantly more prevalent in hospital settings in comparison to other equally resistant strains. This provokes the question whether or not there are phenotypic characteristics that may render certain K. pneumoniae more suitable for epidemic dispersal between patients, hospitals, and different environments. In this study, we selected seven epidemic and non-epidemic ca…
Modelling the removal and reversible immobilization of murine noroviruses in a Phaeozem under various contamination and rinsing conditions
2018
International audience; Enteric viruses entering the soil with contaminated irrigation water can reach groundwater or be internalized in plants through their roots without being inactivated. Their fate in the soil depends on the virus, the soil and the soil solution. In order to write a mathematical model suitable for a Calcaric Phaeozem, we investigated the removal of murine norovirus and reversible immobilization in aggregate columns according to a saturation procedure, conditions between contamination and rinsing time, temperature and soil solution. Viruses were quantified before and after 0.45‐μm filtration with an RT‐qPCR (real‐time polymerase chain reaction). Experimental results supp…
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…
(A,B) In vivo GCaMP6f signals recorded in layers M1, M5 and M9/10 of Mi1 (A) and Tm3 (B) neurons, before (blue, green) and after (gray, red) applicat…
2019
Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specifi…
Hidalgo ja käsikirjoittaja : tekijän näkökulma adaptaatioon ja visuaaliseen kerrontaan laajassa sarjakuvassa
2006
Visuaaliset resurssit suomi toisena kielenä -oppitunneilla : multimodaalinen näkökulma
2013
Oppimateriaaleilla ja muilla luokassa käytetyillä resursseilla on suuri vaikutus siihen, millaiseksi oppimisympäristö muotoutuu ja millaista toimintaa se mahdollistaa. Useat kansainväliset tutkimukset ovat osoittaneet, että visuaalisten ja multimodaalisten resurssien hyödyntäminen kielen opetuksessa auttaa rakentamaan oppimisympäristöä, joka on pedagogisesti rikas, motivoiva sekä monipuolisia oppimisprosesseja tukeva. Visuaalisuuden roolia suomalaisessa kielen oppimisen kontekstissa ei kuitenkaan ole tutkittu juuri lainkaan. Tutkielman kiinnostuksen kohteena on visuaalisuus hyvin laajasti ymmärrettynä, jolloin perinteisten kuvien lisäksi siihen kuuluvat myös esimerkiksi eleet, esineet, liik…
Electrophysiological evidence supports the role of sustained visuospatial attention in maintaining visual WM contents
2019
Recent empirical and theoretical work suggests that there is a close relationship between visual working memory (WM) and visuospatial attention. Here, we investigated whether visuospatial attention was involved in maintaining object representations in visual WM. To this end, the alpha lateralization and contralateral delay activity (CDA) were analyzed as neural markers for visuospatial attention and visual WM storage, respectively. In the single-task condition, participants performed a grating change-detection task. To probe the role of visuospatial attention in maintaining WM contents, two color squares were presented above and below the fixation point during the retention interval, which …
The avidin protein family : properties of family members and engineering of novel biotin-binding protein tools
2005
Eliöiden perimä sisältää kullekin lajille tyypillisen geneettisen tiedon ja määrittelee niiden ominaisuuksia. Lajien perimän yksityiskohtainen tarkastelu ja vertailu selvittää lajien ominaisuuksien perustaa. Suuri osa perimän sisältämistä geeneistä koodaa proteiineja, jotka ovat keskeisiä solujen rakenteille ja toiminnoille.Vesa Hytönen tarkasteli väitöskirjassaan kanan avidiini-proteiinin ja samaan geeniperheeseen kuuluvien avidiinin kaltaisten geenien (AVR) koodaamien AVR-proteiinien tuottamista ja ominaisuuksia. Avidiinin tehtävä on sitoa vesiliukoista H-vitamiinia, jota kutsutaan myös biotiiniksi. Avidiinia esiintyy erityisesti kananmunan valkuaisessa, jossa sen arvellaan toimivan puolu…
Lipid-related thiamine deficiency cause mortality of river lampreys (Lampetra fluviatilis) during pre-spawning fasting
2023
Publisher Copyright: © 2023 The Authors River lampreys (Lampetra fluviatilis) were caught in the fall 2014 on entering the River Perhonjoki for spawning and kept at a hatchery until spawning in late spring 2015 to produce larvae for compensatory stockings. Since the lampreys died massively from early February onwards, they were investigated in March and May to clarify the cause of the deaths. The symptoms in lampreys resembled those of lipid-related thiamine (vitamin B1) deficiency of salmonines, called the M74 syndrome in the Baltic Sea area. Because the lipid content of lampreys was known to be high, thiamine concentrations were analyzed in the liver and ovulated unfertilized eggs, and th…