Search results for "TARGET"

Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Ne…

2021

The mitochondrial serine protease HTRA2 has many versatile biological functions ranging from being an important regulator of apoptosis to being an essential component for neuronal cell survival and mitochondrial homeostasis. Loss of HTRA2 protease function is known to cause neurodegeneration, whereas overactivation of its proteolytic function is associated with cell death and inflammation. In accordance with this, our group verified in a recent study that the synthetic peptide ASGYTFTNYGLSWVR, encoding the hypervariable sequence part of an antibody, showed a high affinity for the target protein HTRA2 and triggered neuroprotection in an in vitro organ culture model for glaucoma. To unravel t…

FRI0030 Anti-TNF-α Antibody Targeted To Inflamed Synovial Tissue for The Treatment of Rheumatoid Arthritis

2016

Background TNF-α neutralizing molecules represent one of the most efficient therapeutic approaches to control inflammation in rheumatoid arthritis (RA). The widespread distribution in the body induces the inhibition of TNF-α in all the tissues, requesting the use of high dose of this expensive drug. Another problem that has not yet been solved in the management of RA patients is how to reduce and possibly avoid the side effects, particularly the increased risk of common and opportunistic infections, which may be associated with long-term administration of these therapeutic drugs. Objectives The aim of the present investigation was to show that a recombinant protein obtained by fusing a syno…

Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.

2021

Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…

Principles of social media monitoring and analysis software

2013

Winnie-the-Pooh through decades and across cultures : translation of culture-bound features in children's literature

2000

The matrix metalloproteinase and insulin-like growth factor system in oral cancer – a prospective clinical study

2017

Eik Schiegnitz,1 Peer W Kämmerer,2 Holger Schön,1 Christoph Gülle,1 Manfred Berres,3,4 Keyvan Sagheb,1 Bilal Al-Nawas5 1Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, 2Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre Rostock, Rostock, 3Department of Mathematics and Technology, University of Applied Sciences Koblenz, Remagen, 4Institute of Medical Biometry, Epidemiology and Informatics, Johannes Gutenberg University of Mainz, Mainz, 5Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre, Martin-Luther U…

User experience targets as design drivers:A case study on the development of a remote crane operator station

2013

In recent years, the notion of user experience, or UX, as an essential aspect to be addressed in the design and development of technologies has been increasingly discussed. In this paper, we present a case study in which we have used UX targets as the main design drivers and focus areas in developing a new remote operator station user interface for container cranes. UX targets describe the experiential qualities to which the product design should aim at. However, taking UX targets into consideration during product design is challenging, because only little is known about how they would be best operationalized to serve the different phases of the design process. Through our case study, we de…

UAV-based hyperspectral monitoring of small freshwater area

2014

Recent development in compact, lightweight hyperspectral imagers have enabled UAV-based remote sensing with reasonable costs. We used small hyperspectral imager based on Fabry-Perot interferometer for monitoring small freshwater area in southern Finland. In this study we shortly describe the utilized technology and the field studies performed. We explain processing pipeline for gathered spectral data and introduce target detection-based algorithm for estimating levels of algae, aquatic chlorophyll and turbidity in freshwater. Certain challenges we faced are pointed out.

Methods for estimating forest stem volumes by tree species using digital surface model and CIR images taken from light UAS

2012

In this paper we consider methods for estimating forest tree stem volumes by species using images taken from light unmanned aircraft systems (UAS). Instead of using LiDAR and additional multiband imagery a color infrared camera mounted to a light UAS is used to acquire both imagery and the DSM of target area. The goal of this study is to accurately estimate tree stem volumes in three classes. The status of the ongoing work is described and an initial method for delineating and classifying treetops is presented.

From influencee to influencer : the rhizomatic target audience of the cyber domain

2015

The messages of an influence operation are interpreted in a variety of ways by their receivers. To increase the probability of success, these messages are typically tailored to affect a defined group, a target audience. Target audience analysis (TAA) is a process of finding suitable target audiences for influence operations. There are multiple ways of completing the task, ranging from fast and intuitive to complex multi-staged processes. These processes use the information available at the moment of making presumptions about the effectiveness of competing approaches in order to choose those with best end results. The internet presents a challenge to this type of sequential, linear process b…