Search results for "TB"

Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2

2020

Abstract Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl‐N‐(1‐(naphthalen‐1‐yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS‐CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS‐CoV‐2 replication in …

Enabling early sleeping and early data transmission in wake-up radio-enabled IoT networks

2019

Abstract Wireless sensor networks (WSNs) are one of the key enabling technologies for the Internet of things (IoT). In such networks, wake-up radio (WuR) is gaining its popularity thanks to its on-demand transmission feature and overwhelming energy consumption superiority. Despite this advantage, overhearing still occurs when a wake-up receiver decodes the address of a wake-up call (WuC) which is not intended to it, causing a certain amount of extra energy waste in the network. Moreover, long latency may occur due to WuC address decoding since WuCs are transmitted at a very low data rate. In this paper, we propose two schemes, i.e., early sleeping (ES) and early data transmission (EDT), to …

Unreliable predictions about COVID‐19 infections and hospitalizations make people worry: The case of Italy

2021

Joint Usage of Dynamic Sensitivity Control and Time Division Multiple Access in Dense 802.11ax Networks

2016

It is well known that in case of high density deployments, Wi-Fi networks suffer from serious performance impairments due to hid- den and exposed nodes. The problem is explicitly considered by the IEEE 802.11ax developers in order to improve spectrum efficiency. In this pa- per, we propose and evaluate the joint usage of dynamic sensitivity con- trol (DSC) and time division multiple access (TDMA) for improving the spectrum allocation among overlapping 802.11ax BSSs. To validate the solution, apart from simulation, we used a testbed based on the Wireless MAC Processor (WMP), a prototype of a programmable wireless card.

MEDiSN

2010

Staff shortages and an increasingly aging population are straining the ability of emergency departments to provide high quality care. At the same time, there is a growing concern about hospitals' ability to provide effective care during disaster events. For these reasons, tools that automate patient monitoring have the potential to greatly improve efficiency and quality of health care. Towards this goal, we have developed MEDiSN , a wireless sensor network for monitoring patients' physiological data in hospitals and during disaster events. MEDiSN comprises Physiological Monitors (PMs), which are custom-built, patient-worn motes that sample, encrypt, and sign physiological data and Relay Po…

Testbed evaluation of optimized REACT over multi-hop paths

2018

REACT is a distributed resource allocation protocol that computes a max-min allocation of airtime for mesh networks. The allocation adapts automatically to changes in local traffic load and in local network views. SALT, a new contention window tuning algorithm, ensures that each node secures the airtime allocated to it by REACT. REACT and SALT are extended to the multi-hop flow scenario with the introduction of a new airtime reservation algorithm. With a reservation in place, multi-hop TCP flows show increased throughput when running over SALT and REACT compared to running over 802.11 DCF. All results are obtained from experimentation on the w-iLab.t wireless network testbed in Belgium.

Smart Manufacturing Testbed for the Advancement of Wireless Adoption in the Factory

2020

Wireless communication is a key enabling technology central to the advancement of the goals of the Industry 4.0 smart manufacturing concept. Researchers at the National Institute of Standards and Technology are constructing a testbed to aid in the adoption of wireless technology within the factory workcell and other harsh industrial radio environments. In this paper the authors present a new industrial wireless testbed design that motivates academic research and is relevant to the needs of industry. The testbed is designed to serve as both a demonstration and research platform for the wireless workcell. The work leverages lessons learned from past testbed incarnations that included a dual r…

A Direct Approach to Robot Soccer Agents: Description for the Team Mainz Rolling rains Simulation League of RoboCup ’98

1999

In the team described in this paper we realize a direct approach to soccer agents for the simulation league of the RoboCup '98- tournament. Its backbone is formed by a detailed world model. Based on information which is reconstructed on the world model level, the rule-based decision levels chose a relevant action. The architecture for the goalie is different from the regular players, introducing heterogeneousness into the team, which combines the advantages of the different control strategies.

Proposals to innovate and investigate about understanding of the environment in Pre-school and Primary Education.

2017

Para hacer frente a los obstáculos institucionales que frenan las iniciativas docentes se han editado en los últimos años algunos manuales que buscan desarrollar actividades de formación (lecturas, debates, tareas de observación en las aulas) para facilitar la toma de decisiones del futuro docente de Educación Infantil y Primaria. Algunos manuales se presentan como síntesis de trabajos específicos, procedentes en algunos casos de propuestas de innovación y, en otros casos, de investigaciones, bien sean Tesis doctorales o bien otros formatos de carácter formal e informal. Pero, por otra parte, aparecen manuales que relacionan las propuestas de investigación e innovación. Es el caso de los li…

Characterization of the LGBTI-speaking community discourse. An approach to Hispanic queer linguistics.

2020

Toda subcultura forma una comunidad lingüística particular en la que, aunque se comparta la lengua con el resto de la sociedad, varía el habla en ciertos aspectos. Es el caso de la comunidad de habla LGTBI, que se hace servir de un léxico peculiar, así como una fraseología característica, unas estructuras gramaticales especiales y, en definitiva, unos recursos pragmáticos muy llamativos que tienen como objetivo mitigar ciertos enunciados, intensificar otros en determinados contextos y construir actos de habla afiliativos que expresen solidaridad social. Por otro lado, cumple una función muy importante en la construcción identitaria de sus usuarios. En este trabajo se propone un análisis pra…