Search results for "TB"
showing 10 items of 2582 documents
Open innovation and firms performance: state of the art and empirical evidences from the bio-pharmaceutical industry
2016
The research presented in this paper explores the effect of inbound, outbound and coupled open innovation practices on firms' performances in the biopharmaceutical industry. Specifically, although existing researches on open innovation effectiveness have separately investigated the effect of open innovation practices on innovation and financial performance, this study evaluates the concurrent effect of these practices on both such performance dimensions in a single framework. We state the importance for a manager to explore concurrently the influence of specific open innovation practices both on innovation and economic-financial performance. We empirically test our framework on a sample of …
Individuālās pieejas realizācija skolēnu mācību sasniegumu veicināšanai
2016
Maģistra darba "Individuālās pieejas realizācija skolēnu mācību sasniegumu veicināšanai" aktualitāti nosaka iekļaujošās izglītības paradigma un skolēnu ar mācīšanās grūtībām skaita pieaugums vispārizglītojošās skolās. Visiem ir jāiegūst izglītība, lai varētu kļūt par līdzvērtīgu sabiedrības sastāvdaļu, bet skolēni ir dažādi, katrs mācās citādāk. Viens tiek galā pats, bet citam būs nepieciešama lielāka palīdzība un atbalsts. Kādam būs jāatrod īpaša, individuāla pieeja. Pētījuma centrā- atbalsts skolēniem ar mācīšanās grūtībām vispārizglītojošā skolā, izmantojot vienu no individuālās palīdzības veidiem Individuālo Izglītības plānu. Darba mērķis ir izpētīt, kādi faktori veicina vai kavē skolēn…
A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin
2013
A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5- (1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl compounds 12a-e and 1,2-diaza-1,3-diene (DD) 13. Derivatives 10a,c-e, deazaanalogues of the bis-indole alkaloid topsentin, screened by the National Cancer Institute (Bethesda, MD, USA) in the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity, with the exception of compound 9e, which showed moderate activity against the HOP-92 cell line of the non small cell lung cancer sub-p…
Akomodācijas atbilde anizometropijas gadījumā
2019
Maģistra darbs uzrakstīts latviešu valodā, datorsalikumā uz 42 lapām. Tas satur 21 attēlu, 4 tabulas, 5 formulas un 25 atsauces uz literatūras avotiem. Darba mērķis: Novērtēt akomodācijas atbildi, dažādu anizometropijas pakāpju apstākļos. Pētījuma dalībnieki: Pētījumā piedalījās 24 dalībnieki, no tiem 20 dalībnieki vecumā no 19 – 28 gadiem (22,12 ± 2,74), ir pētāmā grupa, kurai tiek inducēta anizometropija, bet 4 dalībnieki vecumā no 19 – 21 gadiem ( 20 ± 0,71), ir pētāmā grupa ar pastāvīgu anizometropiju. Izmantojot vienas dienas kontaktlēcas, tika inducēti četri anizometropijas lielumi. Lai noteiktu akomodācijas atbildi tika izmantots ekscentrisks fotorefraktometrs PowerRef3. Rezultāti ne…
Discrimination of non-infectious SARS-CoV-2 particles from fomites by viability RT-qPCR.
2021
The ongoing coronavirus 2019 (COVID-19) pandemic constitutes a concerning global threat to public health and economy. In the midst of this pandemic scenario, the role of environment-to-human COVID-19 spread is still a matter of debate because mixed results have been reported concerning SARS-CoV-2 stability on high-touch surfaces in real-life scenarios. Up to now, no alternative and accessible procedures for cell culture have been applied to evaluate SARS-CoV-2 infectivity on fomites. Several strategies based on viral capsid integrity have latterly been developed using viability markers to selectively remove false-positive qPCR signals resulting from free nucleic acids and damaged viruses. T…
Viability RT-qPCR to detect potentially infectious enteric viruses on heat-processed berries
2019
Berries have frequently been cited as causing gastroenteritis and acute hepatitis outbreaks due to enteric virus contamination, including human norovirus and hepatitis A virus (HAV). Model experiments were performed to evaluate the potential use of viability RT-qPCR to assess the thermal inactivation of norovirus genotype I (GI), GII, and HAV on raspberries, blueberries and strawberries. Initially, two viability markers, platinum chloride and propidium monoazide (PMAxx™), were compared using thermally inactivated norovirus GI and GII suspensions. The results showed better performance of PMAxx™ pretreatment in discriminating native and inactivated viruses. Thus, the pretreatment was optimize…
Organoids of human airways to study infectivity and cytopathy of SARS-CoV-2
2020
Viability RT-PCR for SARS-CoV-2: a step forward to solve the infectivity quandary
2021
Background Isolation, contact tracing and restrictions on social movement are being globally implemented to prevent and control onward spread of SARS-CoV-2, even though the infection risk modelled on RNA detection by RT-qPCR remains biased as viral shedding and infectivity are not discerned. Thus, we aimed to develop a rapid viability RT-qPCR procedure to infer SARS-CoV-2 infectivity in clinical specimens and environmental samples. Methods We screened monoazide dyes and platinum compounds as viability molecular markers on five SARS-CoV-2 RNA targets. A platinum chloride-based viability RT-qPCR was then optimized using genomic RNA, and inactivated SARS-CoV-2 particles inoculated in buffer, s…
Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021
2021
COVID study groups - PORTUGAL: Portuguese Laboratory Network for the Diagnosis of COVID-19 and Public Health Department of the Health Administrative Regions, Physicians that provided data and samples from suspected cases and SARS-CoV-2 genetic characterization. INSA laboratory team for the diagnosis of SARS-CoV-2. Algarve Biomedical Center and Unilabs. We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95…
The gender gap in the diagnostic-therapeutic journey of the infertile couple
2021
Medical procreation impairs both the biological and psychological lives of couples. However, male and female attitudes to infertility are different and require a different approach during the IVF journey. Thus, the gender impact assessment (GIA) method was used to analyse original studies present in the literature. We found some gender-related differences and, subsequently, possible outcomes of intervention to improve healthy reproduction management and prevent infertility. In particular, it became apparent that there was the need for an in-depth male infertility assessment and a gender-specific follow-up.