Search results for "TB"
showing 10 items of 2582 documents
Adolescents’ preparedness and motivation across the transition to post-comprehensive education
2017
This longitudinal study aims to test the concept of transition preparedness in the context of educational transitions. The study investigates how adolescents' transition preparedness, conceptualized as their self-efficacy beliefs and their inoculation against setbacks, before an educational transition affect the adolescents' school value and effort related to educational goals after the transition through the effects on achievement goal orientations. Student data from three waves of a longitudinal study are used, first collected in 2004 (before the students' transition from comprehensive school to upper secondary education) and then collected twice after the transition. The students include…
Mazo un vidējo uzņēmumu attīstība Zemgalē
2015
Bakalaura darba tēma ir Mazo un vidējo uzņēmumu attīstība Zemgalē. MVU Latvijā sastāda 99% no visiem uzņēmumiem un tiem ir ļoti būtiska nozīme tautsaimniecībā, jo tie tieši ietekmē bezdarba līmeni valstī un iedzīvotāju labklājību. Turklāt mazie un vidējie uzņēmumi rada lielāko daļu iekšzemes kopprodukta. Reģistrēto uzņēmu skaits ir strauji audzis kopš 2010. gada, taču liela daļa jauno uzņēmumu savu darbību pārtrauc pirmajos trīs gados, jo nākas saskarties ar dažādām attīstības problēmām, kā piemēram, nodokļu slogs, konkurence, mazs pieprasījums, kvalificētu darbinieku trūkums u. c. Attīstītākā uzņēmējdarbības vide ir Rīgā, kur arī ir reģistrēti vairāk kā puse Latvijas uzņēmumu. Sarežģītāk i…
Finanšu analīzes pielietojums uzņēmumā SIA “Visma “Enterprise” finanšu stāvokļa noteikšanai pēc reorganizācijas
2020
Diplomdarba tēma ir “Finanšu analīzes pielietojums uzņēmumā SIA “Visma Enterprise” finanšu stāvokļa noteikšanai pēc reorganizācijas” Šī darba mērķis ir uz teorētisko un praktisko materiālu pamata veikt uzņēmuma “Visma Enterprise” finanšu analīzi pirms un pēc uzņēmuma reorganizācijas Diplomdarbā iegūtie rezultāti liecina, ka uzņēmums pēc 2014. gadā notikušās reorganizācijas ir veiksmīgi turpinājis savu saimniecisko darbību, ir paplašinājies un nostiprinājis sevi konkurences tirgū. Diplomdarbs satur 3 nodaļas, pirmajā nodaļā autore iepazīstas ar pētāmā uzņēmuma vēsturi. Otrajā nodaļā tiek veikta uzņēmuma “Visma Enterprise” saimnieciskās darbības analīze. Trešajā nodaļā tiek veikti finanšu ana…
Females tend to prefer genetically similar mates in an island population of house sparrows.
2014
11 pages; International audience; BACKGROUND: It is often proposed that females should select genetically dissimilar mates to maximize offspring genetic diversity and avoid inbreeding. Several recent studies have provided mixed evidence, however, and in some instances females seem to prefer genetically similar males. A preference for genetically similar mates can be adaptive if outbreeding depression is more harmful than inbreeding depression or if females gain inclusive fitness benefits by mating with close kin. Here, we investigated genetic compatibility and mating patterns in an insular population of house sparrow (Passer domesticus), over a three-year period, using 12 microsatellite mar…
TBL1XR1 mutations in Pierpont syndrome are not restricted to the recurrent p.Tyr446Cys mutation
2018
IF 2.264; International audience; Pierpont syndrome is a rare and sporadic syndrome, including developmental delay, facial characteristics, and abnormal extremities. Recently, a recurrent de novo TBL1XR1 variant (c.1337A > G; p.Tyr446Cys) has been identified in eight patients by whole‐exome sequencing. A dominant‐negative effect of this mutation is strongly suspected, since patients with TBL1XR1 deletion and other variants predicting loss of function do not share the same phenotype. We report two patients with typical Pierpont‐like syndrome features. Exome sequencing allowed identifying a de novo heterozygous missense TBL1XR1 variant in both patients, different from those already reported: …
Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice
2021
This article belongs to the Special Issue Gut Microbiota and Immunity.
Analysis of the Possible Persistent Genotoxic Damage in Workers Linked to the Ardystil Syndrome
2016
[EN] Background: A combination of several factors including a change in the paint application system; a lack of proper hygiene; and inadequate safety measures caused a severe health impact in the workers of some textile painting factories. This outbreak, mainly characterized by respiratory disorders, caused the death of six people and it has been classified as Ardystil syndrome. Materials and Methods: Fifty-two workers involved in the outbreak and 48 healthy subjects not known to have exposed to the potentially mutagenic agents participated in the study. The program evaluated possible genotoxic damage through the sister chromatid exchange (SCE) cytogenetic biomarker assay. We determined the…
Outbreak of IMI-1 Carbapenemase-producing colistin-resistant Enterobacter cloacae on the French island of Mayotte (Indian Ocean)
2018
International audience; The spread of carbapenemase-producing Enterobacteriaceae in the Southwest Indian Ocean islands is poorly known. Here we describe an outbreak of colistin-resistant Enterobacter cloacae harbouring blaIMI-1 in the French overseas department of Mayotte. Between October 2015 and January 2017, all isolates of imipenem-non-susceptible E. cloacae at Mayotte Medical Center and University Hospital of Reunion Island were screened for carbapenemase production. Positive isolates were typed by pulsed-field gel electrophoresis and whole-genome sequencing (WGS)-based multilocus sequence typing (MLST), and all β-lactamase genes were identified by PCR and sequencing. Resistance profil…
Expanding the β-III Spectrin-Associated Phenotypes toward Non-Progressive Congenital Ataxias with Neurodegeneration
2021
(1) Background: A non-progressive congenital ataxia (NPCA) phenotype caused by b-III spectrin (SPTBN2) mutations has emerged, mimicking spinocerebellar ataxia, autosomal recessive type 14 (SCAR14). The pattern of inheritance, however, resembles that of autosomal dominant classical spinocerebellar ataxia type 5 (SCA5). (2) Methods: In-depth phenotyping of two boys studied by a customized gene panel. Candidate variants were sought by structural modeling and protein expression. An extensive review of the literature was conducted in order to better characterize the SPTBN2-associated NPCA. (3) Results: Patients exhibited an NPCA with hypotonia, developmental delay, cerebellar syndrome, and cogni…
Waterborne Norovirus outbreak at a seaside resort likely originating from municipal water distribution system failure
2018
AbstractIn May 2016 a Norovirus (NoV) gastroenteritis outbreak involved a high school class visiting a seaside resort near Taormina (Mascali, Sicily). Twenty-four students and a teacher were affected and 17 of them showed symptoms on the second day of the journey, while the others got ill within the following 2 days. Symptoms included vomiting, diarrhoea and fever, and 12 students required hospitalisation. Stool samples tested positive for NoV genome by Real-Time polymerase chain reaction assay in all 25 symptomatic subjects. The GII.P2/GII.2 NoV genotype was linked to the outbreak by ORF1/ORF2 sequence analysis. The epidemiological features of the outbreak were consistent with food/waterbo…