Search results for "TCA."

Nonsense-mediated decay mechanism is a possible modifying factor of clinical outcome in nonsense cd39 beta thalassemia genotype

2012

Nonsense-mediated mRNA decay (NMD) is a surveillance system to prevent the synthesis of non-functional proteins. In β-thalassemia, NMD may have a role in clinical outcome. An example of premature translation stop codons appearing for the first time is the β-globin cd39 mutation; when homozygous, this results in a severe phenotype. The aim of this study was to determine whether the homozygous nonsense cd39 may have a milder phenotype in comparison with IVS1,nt110/cd39 genotype. Genotypes have been identified from a cohort of 568 patients affected by β-thalassemia. These genotypes were compared with those found in 577 affected fetuses detected among 2292 prenatal diagnoses. The…

Tratamiento jurídico de una enfermedad social. Los trastornos de la conducta alimentaria (TCA)

2018

The boundless increase of people suffering from an Eating Disorder (ED), makes necessary to develop measures related to other factors, in order to overcome the ones characterized of being strictly sanitary. The disease has become a social and cultural phenomenon. The exaltation of the cult to the body, with the stereotype of the extreme thinness linked with beauty and success is causing that, particularly young people, try to achieve an image which, in many cases, can jeopardize their health, that is the reason why the rearrangement of values has become an objective of paramount importance. Therefore, the fight against this social illness requires legal actions in order to prevent it from g…

Exploratory analysis of safety data and their interrelation with flight trajectories and network metrics

2013

This paper presents an exploratory analysis of the correlation between different network metrics and safety events. The objective is to develop analysis methods and indicators that relate the network structure with safety events. In particular by using data gathered with an automatic tool developed by EUROCONTROL and a database of traffic data, we measured the correlations between the classical metrics of the airspace network, especially the network of navigation points, and the occurrence of Short Term Conflicts Alerts (STCA). The results obtained are not univocal; correlation between STCA occurrences and classical network metrics are present but the correlation coefficient is around 0.7. …

Livelli di rappresentazione del testo nell’edizione del De nomine di Orso Beneventano

2018

Viene presentato l’impianto metodologico e tecnologico dell’edizione critica digitale del De nominedi Orso Beneventano (http://www.unipa.it/paolo.monella/ursus), una proof of concept delle innovazioni metodologiche proposte da Tito Orlandi. Il modello qui sperimentato intende superare la dicotomia tra edizione diplomatica e critica grazie ad un ripensamento profondo, semioticamente fondato, dei livelli di trascrizione e di edizione di un testo. I livelli scelti per questa edizione sono: (1) Livello grafematico, le cui unità minime sono i grafemi, inclusi i segni paragrafematici e le brachilogie sistematiche. Tutti i grafemi individuati dall’editore sono elencati nella Graphemic Table of Sig…

Photocatalytic oxidation in green organic solvent: the case study of water-insoluble phenanthrene

2014

Mécanismes moléculaires et cellulaires des œstrogènes et des phyto-oestrogènes

2005

Effets des phyto-oestrogènes sur les cancers

2005

Métabolisme des molécules amères : quel lien avec la perception gustative et l'information toxicologique ?

2018

Value Co-Creation Opportunities: Managerial Transformation of Digitisation Risks into Success Factors

2018

This chapter examines the challenges and risks managers in the healthcare sector perceive in relation to the development and implementation of digitised services in a healthcare case organisation. Using data collected from managers, focus group interviews and observation method within the case organisation, the authors present an analysis that demonstrates that the risks and success factors that influence the development and implementation of digital healthcare services are related to (1) setting a clear digital strategy and implementation plan, (2) integration of digital services with the overall process and ICT, (3) committed resources and engagement of personnel, and (4) the organisation…

In vitro hazard assessment of nanoparticles developed for biomedical applications

2016

Nanotechnology is a growing sector in industry for twenty years and nanomaterials are currently used in numerous industrials applications. Their interest is based on their dimensions and their shape that give them very particular technological and biological properties. However, the development of these nanoparticles, their industrial preparation and integration into various products already involve an initial increased of human exposure (via inhalation, percutaneous and oral route). Another exposure pathway exists and is represented by drug injections. The risks associated with these new technologies and new products are still unclear. After a characterization step (zeta potential, TEM, TG…