Search results for "TCR"

RAPD variation within and among natural populations of outcrossing willow-leaved foxglove (Digitalis obscura L.)

1999

Random amplified polymorphic DNA (RAPD) markers were used to assess levels and patterns of genetic diversity in Digitalis obscura L. (Scrophulariaceae), an outcrossing cardenolide-producing medicinal plant species. A total of 50 plants from six natural populations on the Iberian Peninsula were analysed by six arbitrarily chosen decamer primers resulting in 96 highly reproducible RAPD bands. To avoid bias in parameter estimation, analyses of population genetic structure were restricted to bands (35 of 96) whose observed frequencies were less than 1–3/n in each population. The analysis of molecular variance (AMOVA) with distances among individuals corrected for the dominant nature of RAPDs (g…

TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer.

2021

Simple Summary High-grade serous ovarian carcinoma (HGSC) could be analyzed with a molecular stratification defined by different genomic instability signatures associated with specific mutational process and prognostic biomarkers. Immune infiltrate is known to be a robust biomarker in HGSC. We aimed to investigate immune parameters according to genomic instability signatures. We observed that homologous recombination deficiency positive, copy cumber variant signature 7 and TCR (T cells receptor) clonality are good prognostic biomarkers in HGSC. Combining TCR clonality and genomic instability signature or T cell infiltration improved the prognostic value compared to each variable taken alone…

A NEW AREA OF ALKALINE ROCKS IN EASTERN PARAGUAY

1992

Alkaline rocks can be found in three major areas (northern, northeastern and central-eastern) of Eastern Paraguay. On die basis of geographic distribution and tectonic association, Livieres & Quade (1987) proposed inclu- sion of these outcrop areas different alkaline provinces: Alto Paraguay, Amambay and Central, respectively (Fig. 1). Presently, only the Central Province, clustering the largest number of occurrences, is the subject of systematic investigation. Available information on the Alto Paraguay and Amambay rocks is still scarce.

1994

Giraffid remains from several Neogene localities from the Temel Basin (Spain) are stu­ died. The material belongs to the following sites: Masia de la Roma and Masia del Barbo (Vallesian); Masada del Valle 2 (Turolian); La Gloria 4 and La Calera (Alfambrian). Fos­ sils recently obtained are described, with special emphasis on the Pliocene taxa that were previously unrecorded in this basin. The presence of Decennatheriumpachecoi in the Va­ llesian and Birgerbohlinia schaubi in the Turolian is specified here. In order to make a dis­ tinction between both species two characteristics can be pointed out among the rest: the postcranial skeleton of Decennatherium is more slender than the one of Bir…

Characterization of a fractured basement reservoir using high-resolution 3D seismic and logging datasets: A case study of the Sab'atayn Basin, Yemen.

2018

The Sab'atayn Basin is one of the most prolific Mesozoic hydrocarbon basins located in central Yemen. It has many oil producing fields including the Habban Field with oil occurrences in fractured basement rocks. A comprehensive seismic analysis of fractured basement reservoirs was performed to identify the structural pattern and mechanism of hydrocarbon entrapment and reservoir characteristics. A 3D post-stack time migration seismic cube and logging data of 20 wells were used and several 2D seismic sections were constructed and interpreted. Depth structure maps were generated for the basement reservoir and overlying formations. The top of the basement reservoir is dissected by a set of NW-S…

Ein neues captorhinomorphes reptil aus dem thüringischen rotliegend (Unter-Perm; Ost-Deutschland)

1991

Thuringothyris mahlendorffae n.gen. n.sp. is described on the basis of the skull roof, palate, stapes and much of the postcranial skeleton from the Upper Rotliegend (Tambach-Schichten) of the Thuringian Forest in eastern Germany. The new taxon shows both protorothyridid and some captorhinid features. The interrelationships of the »Protorothyrididae«, primitive Captorhinidae, and earliest Diapsida are reviewd. The tetrapod material is used to reassess the biostratigraphic position of the fossil-bearing horizon.

Modelling, Identification and Control of a 5-DOF Shotcrete Robot : Development of a Framework for Automatic Application of Shotcrete for AMV 4200H

2019

Master's thesis Mechatronics MAS500 - University of Agder 2019 Today, process automation is the primary area of development in the shotcrete industry. Automaticshotcrete operations can yield an increase in operational efficiency and personnel safety as well asreductions in cost and environmental impact. This thesis develops a framework for automaticapplication of shotcrete using the AMV 4200H and provides an automatic spraying mode usinginteroceptive sensing. The shotcrete vehicle is equipped with a five degrees-of-freedom manipulatorand is currently operated manually. Our contributions include solving the forward kinematicsthrough the Denavit-Hartenberg convention, and the inverse kinemati…

Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review

2019

Background Vaccine adjuvants are compounds that significantly enhance/prolong the immune response to a co-administered antigen. The limitations of the use of aluminium salts that are unable to elicite cell responses against intracellular pathogens such as those causing malaria, tuberculosis, or AIDS, have driven the development of new alternative adjuvants such as QS-21, a triterpene saponin purified from Quillaja saponaria. Purpose The aim of this review is to attempt to clarify the mechanism of action of QS-21 through either receptors or signaling pathways in vitro and in vivo with special emphasis on the co-administration with other immunostimulants in new adjuvant formulations, called a…

(Table 1) Trace element/Ca ratios of Orbulina universa shells from late Neogene Mediterranean samples

2008

A Mediterranean composite sedimentary record was analyzed for Ba/Ca ratios on carbonate shells of Orbulina universa planktonic foraminifer (Ba/Ca)carb providing the opportunity to study and assess the extent of freshwater inputs on the basin and possible impacts on its dynamics during the Tortonian to Recent period. A number of scanning electron microscope analyses and auxiliary trace element measurements (Mn, Sr, and Mg), obtained from the same samples, exclude important diagenetic effects on the studied biogenic carbonates and corroborate the reliability of (Ba/Ca)carb ratios in foraminifera calcite as indicators of seawater source components during the studied interval. A long-term trend…

Interpretation of Structures and Fabrics Recognition and Interpretation of Fabric Patterns in Outcrop

1990

High-grade gneisses with a long and complex history have a finite ‘memory’ of past events. This memory is formed by fabric elements such as foliations, lineations, folds, mineral assemblages, boudins and sequences of intrusion. One of the aims of a geologist is to tap this memory as effectively as possible. The memory of rocks, however, is rather inadequate in that it is partly destroyed by the same events which produce the fabric elements that are recorded (Williams, 1983). Strong deformation erases older fabric elements; intrusions, recrystallisation and partial melting do the same (Figs. 1.1; 4.1). One of the purposes of this manual is to help geologists working in high-grade gneiss terr…