Search results for "TECNOLOGICO"
showing 10 items of 440 documents
Controlled Drug delivery in Parkinson's Disease - Progress beyond the state-of-the-art
2009
A new dopamine amino-acid conjugate: preclinical in vitro studies and evaluation of behavioural effects in rats
2012
It is well established that alterations in the functionality of dopaminergic transmission are associated with neurodegenerative diseases such as Parkinson’s Disease. The purpose of this study was to investigate the activity of a new dopamine amino-acid conjugate: L-phenylalanine-β-(3,4-dihydroxyphenyl) etilamide(DA-Phe) in the central nervous system, by assessing its influence on different behavioural parameters in the rat. Preliminarily, we tested the in vitro stability in plasmatic environment following the disappearance of DA-Phen from human plasma and the concurrent appearance of dopamine. Using rat brain homogenate, we also evaluated the level of DA-Phen cleavage by cerebral enzymes an…
Development of stimulus-sensitive electrospun membranes based on novel biodegradable segmented polyurethane as triggered delivery system for doxorubi…
2022
In this work, redox-sensitive polyurethane urea (PUU) based electrospun membranes have been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by linking a lipoyl hydrazide to the drug via a hydrazone linkage. First, the lipoyl-hydrazone-doxorubicin derivative labelled as LA-Hy-Doxo has been syn- thesized and characterized. Then, the molecule has been tethered, via a thiol-disulfide exchange reaction, to the redox-sensitive PUU (PolyCEGS) electrospun membrane. The redox-sensitive PolyCEGS PUU has been produced by using PCL-PEG-PCL polyol and glutathione-tetramethyl ester (GSSG-OMe)4 as a chain extender. The LA-Hy- Doxo tethered electrospun membrane has showed a du…
STUDIO DI SISTEMI DI INTERESSE FARMACEUTICO MEDIANTE ANALISI CALORIMETRICA E DI TENSIONE SUPERFICIALE
2011
HYDROPHOBIC POLYMER COATED SUPERPARAMAGNETIC NANOPARTICLES FOR ANTICANCER DRUG DELIVERY
2011
HYDROPHOBIC POLYMER COATED SUPERPARAMAGNETI NANOPARTICLES FOR ANTICANCER DRUG DELIVERY LICCIARDI M.1, SCIALABBA C.1, AMATO G.1, CAVALLARO G.1, GIAMMONA G.1,2 1Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), University of Palermo, via Archirafi 32, 90123, Palermo, Italy. 2IBF-CNR, via Ugo La Malfa, 153, 90143 Palermo, Italy. Superparamagnetic Fe3O4 nanoparticles have been recently used in drug delivery applications [1-4]. In this study, a novel approach to prepare magnetic polymeric nanoparticles containing superparamagnetic domains and hydrophobic polymeric shell using microemulsion-solvent evaporation method is reported. PHEA-IB-poly(ButMA) copolymer was used as …
FOLATE-MEDIATED TARGETING OF POLYMERS AS COMPONENTS OF COLLOIDAL DRUG DELIVERY SYSTEMS
2009
Printable Thermo- and Photo-stable Poly(D,L-lactide)/Carbon Nanodots Nanocomposites via Heterophase Melt-Extrusion Transesterification
2022
We propose for the first time an one-pot synthesis of carbon nanodots-poly(D,L-lactide) (CDs-PLA) nanocomposites, obtained by a simple reactive melt-extrusion process involving polar surface groups of multicolor CDs and ester bonds of PLA chains. Apart from providing an excellent method to produce polyester-coated CDs, our protocol allows obtaining perfect PLA@CDs blends giving rise to homogeneous extruded PLA@CDs filaments (ePLA@CDs) suitable for 3D printing applications (e.g., additive manufacturing for biomaterials and biodegradable encoded polymer ink technology). We demonstrate that ePLA@CDs filaments can be used to build a huge range of fluorescent objects with increasing architectura…