Search results for "TEP"
showing 10 items of 712 documents
Experimental techniques for testing the sensitivity of bladder tumours to antineoplastic drugs
1973
A number of laboratory tests can be employed to examine the sensitivity of human bladder tumour cells to various chemotherapeutic agents.-Their principles and methods, and some preliminary results, are described with special reference to certain in vitro and in vivo cytotoxicity tests and to heterotransplantation in the hamster. Satisfactory agreement has sometimes been observed between experimental results and clinical responses, but our experience is still very limited.-The employment of several such tests would probably lead to a greater degree of reliability in the laboratory assessment of the sensitivity of bladder tumours to cytotoxic drugs.
Long-Term Outcome of Preemptive Immunotherapy Based on Post-Transplant Chimerism and MRD Monitoring after Allogeneic Stem Cell Transplantation in Chi…
2014
Abstract Introduction: Mixed chimerism (MC) and minimal residual disease (MRD) strongly predict risk for relapse in children with acute lymphoblastic leukemia (ALL) following allogeneic stem cell transplantation (allo-SCT). Preemptive immunotherapy (IT), e.g. withdrawal of immunosuppression (WD-IS) or donor lymphocyte infusion (DLI) guided by chimerism and MRD monitoring can prevent impending relapse in allo-SCT recipients. In this study we retrospectively analyzed chimerism and MRD monitoring and the effect of preemptive IT in all pts undergoing allo-SCT for ALL in our institution. Patients: Between January 2005 and July 2014, a total of 89 children and adolescents (median age 11.5; range …
One-step reactive processing of low density polyethylene and octavinyl polyhedral oligomeric silsesquioxane
2015
Polyhedral oligomeric silsesquioxane (POSS) are an innovative class of organosilicon compounds suitable for formulation of advanced organic-inorganic hybrid materials. Nanocomposites based POSS found application mostly in high-temperature resistance and fire-resistance materials. POSS are characterized by a three dimensional cage-like structure, made of Si-O bonds, with different organic groups directly linked to the Si atoms of the cage structure. The organic groups can be designed to facilitate the dispersion of the nanoparticle itself in the polymer matrix or also to react with the polymer chain. This work focuses on the possibility to obtain crosslinking of polyethylene using octavinyl-…
Existence and stability of periodic solutions in a neural field equation
2017
We study the existence and linear stability of stationary periodic solutions to a neural field model, an intergo-differential equation of the Hammerstein type. Under the assumption that the activation function is a discontinuous step function and the kernel is decaying sufficiently fast, we formulate necessary and sufficient conditions for the existence of a special class of solutions that we call 1-bump periodic solutions. We then analyze the stability of these solutions by studying the spectrum of the Frechet derivative of the corresponding Hammerstein operator. We prove that the spectrum of this operator agrees up to zero with the spectrum of a block Laurent operator. We show that the no…
Chalcogenide Photonic Crystal Fibers for Near and Middle Infrared Applications
2007
Chalcogenide glasses are based on sulphur, selenium, tellurium and the addition of other elements such as arsenic, germanium, antimony, gallium, etc. Chalcogenide fibers present numerous applications in the IR field, such as telecommunication at 1.55 mum, spectroscopy and military systems in the two atmospherics windows (3-5 mum and 8-12 mum). One of the interests of chalcogenide glasses is to associate high non linear properties with their Infrared transmission from 0.51 mum to 12-18 mum depending on the composition. Indeed, chalcogenide glasses present high third order optical properties, 100 - 1000 times as high as the non linearity of silica glass at 1.55 mum. For many applications, sin…
Static output-feedback control for vehicle suspensions: a single-step linear matrix inequality approach
2013
In this paper, a new strategy to design static output-feedback controllers for a class of vehicle suspension systems is presented. A theoretical background on recent advances in output-feedback control is first provided, which makes possible an effective synthesis of static output-feedback controllers by solving a single linear matrix inequality optimization problem. Next, a simplified model of a quarter-car suspension system is proposed, taking the ride comfort, suspension stroke, road holding ability, and control effort as the main performance criteria in the vehicle suspension design. The new approach is then used to design a static output-feedbackH∞controller that only uses the suspensi…
First record of Pachycrepoideus vindemmiae (Rondani) (Hymenoptera: Pteromalidae) parasitizing pupae of Ceratitis capitata (Wiedemann) (Diptera: Tephr…
2015
The Mediterranean fruit fly (Medfly), Ceratitis capitata (Wiedemann) (Diptera : Tephritidae), isone of the most devastating pests of fruits and vegetables worldwide (Liquido et al. 1991; Chueca et al. 2007). It is the most invasive species of all members of the Tephritidae (Zucchi 2001) and a key pest of citrus and other fruits in the Mediterranean countries, including Tunisia (Enkerlin & Mumford 1997; Jerraya 2003). Serious economic damage is caused by this insect in Tunisia; in mixed fruit cultivation crop losses can be from 80 to 100% (Jerraya 2003). Citrus is the most affected host crop, with direct annual losses attributed to C. capitata of up to 38% of annual income from Tunisian citr…
Estimating trematode prevalence in snail hosts using a single-step duplex PCR: how badly does cercarial shedding underestimate infection rates?
2014
Background: Trematode communities often consist of different species exploiting the same host population, with two or more trematodes sometimes co-occuring in the same host. A commonly used diagnostic method to detect larval trematode infections in snails has been based on cercarial shedding, though it is often criticized as inaccurate. In the present study we compare infection prevalences determined by cercarial emission with those determined, for the first time, by molecular methods, allowing us to quantify the underestimation of single and double infections based on cercarial emission. We thus developed a duplex PCR for two host-parasite systems, to specifically differentiate between sin…
A human factors intervention in a hospital - evaluating the outcome of a TeamSTEPPS program in a surgical ward
2021
AbstractBackgroundPatient safety in hospitals is being jeopardized, since too many patients experience adverse events. Most of these adverse events arise from human factors, such as inefficient teamwork and communication failures, and the incidence of adverse events is greatest in the surgical area. Previous research has shown the effect of team training on patient safety culture and on different areas of teamwork. Limited research has investigated teamwork in surgical wards. The aim of this study was to evaluate the professional and organizational outcomes of a team training intervention among healthcare professionals in a surgical ward after 6 and 12 months. Systems Engineering Initiative…
Comparison of clot lysis activity and biochemical properties of originator tenecteplase (Metalyse®) with those of an alleged biosimilar
2014
The bioengineered tissue plasminogen activator tenecteplase is an important treatment modality of acute myocardial infarction recommended by international guidelines. Following introduction of originator tenecteplase (brand names Metalyse(®) and TNKase(®)), a "biosimilar" tenecteplase became available for commercial use in India under the brand name Elaxim(®) in the absence of Indian biosimilar guidelines which came into force from September 15th, 2012. Based on a report of biochemical and fibrinolytical differences between Metalyse and Elaxim, we have systematically compared them in a range of routine quality testing assays. As compared to Metalyse, Elaxim exhibited less clot lysis activit…