Search results for "TERMINATION"
showing 10 items of 780 documents
Correlation between neonatal outcomes of twins depends on the outcome : Secondary analysis of twelve randomised controlled trials
2018
ObjectiveTo estimate the magnitude of the correlation between neonatal outcomes of twins and demonstrate how this information can be used in the design of randomised controlled trials (RCTs) in women with twin pregnancies.DesignSecondary analysis of data from 12 RCTs.SettingObstetric care in multiple countries, 2004-2012.Population or sample4504 twin pairs born to women who participated in RCTs to assess treatments given during pregnancy.MethodsIntraclass correlation coefficients (ICCs) were estimated using log-binomial and linear models.Main outcome measuresPerinatal death, respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular haemorrhage, necrotising enterocolitis, s…
Facetten der Körperbildstörung: eine differenzielle Analyse des TEK-KJ (Test zur Erfassung der Körperbildstörung bei Kindern und Jugendlichen) zur di…
2018
Zusammenfassung. Zur Erfassung der haptisch-perzeptiven Komponente der Körperbildstörung – einem Kernkriterium der Essstörungen Anorexia nervosa und Bulimia nervosa – stehen nur sehr wenige gut evaluierte Verfahren zur Verfügung. In der vorliegenden Arbeit werden differenzielle Analysen zum Test zur Erfassung der Körperbildstörung bei Kindern und Jugendlichen (TEK-KJ) anhand einer großen Kinder- und Jugendlichenstichprobe dargestellt und zum ersten Mal Daten für männliche Kinder und Jugendliche ausgewertet. Dies beinhaltet die Prüfung der konvergenten Validität im Vergleich zur Contour Drawing Rating Scale (CDRS) und die Analyse von Unterschieden zwischen Kindern und Jugendlichen verschied…
Estimators and confidence intervals of f2 using bootstrap methodology for the comparison of dissolution profiles
2021
Abstract Background and objectives: The most widely used method to compare dissolution profiles is the similarity factor f 2 . When this method is not applicable, the confidence interval of f 2 using bootstrap methodology has been recommended instead. As neither details of the estimator nor the types of confidence intervals are described in the guidelines, the suitability of five estimators and fourteen types of confidence intervals were investigated in this study by simulation. Methods: One million individual dissolution profiles were simulated for the reference and test populations with predefined target population f 2 values, where random samples of different sizes were drawn without rep…
Argumentos retóricos sobre Interrupción Voluntaria del Embarazo en Colombia. Análisis jurisprudencial desde la teoría de la argumentación jurídica de…
2011
RESUMENEl presente trabajo aborda los conceptos planteados por Chaïm Perelman en su teoría de la argumentación, con el fin de lograr una comprensión del razonamiento en las decisiones judiciales tomadas por la Corte Constitucional de Colombia, en relación a tres casos sobre interrupción voluntaria del embarazo (IVE). En primer lugar, se aborda la teoría de la “Nueva Retórica” de Chaïm Perelman, y en especial su aplicación en el campo del Derecho. A continuación se hace un breve repaso de las premisas de la argumentación y las técnicas argumentativas manteniendo un enfoque de carácter jurídico. Para finalizar, se analiza la motivación de las sentencias de la Corte Constitucional colombiana …
Comparison of Procedures to estimate Steady Flow Rate in Field Measurement of Saturated Hydraulic Conductivity by the Guelph Permeameter Method
1999
Abstract Different procedures for estimating steady flow rate during field application of the Guelph permeameter method were compared in terms of field-saturated hydraulic conductivity K fs and equilibration time t s estimates. The steady flow rate was evaluated by the slope of the linear portion of the cumulative drop in water level in the permeameter reservoir versus time plot (reference procedure) and by approximate procedures that use the first three or four consecutive values of the rate of fall of the water level equal or differing by less than a given percentage. The influence of the selected time interval between two successive readings ( Δt =2 or 10 min) at the permeameter was also…
Blood volume and extracellular space (ECS) of the whole body and some organs of the rat.
1978
Methods are described for estimation of blood volume and extracellular space (ECS) in the whole body and in some organs with 51Cr, 14C-thiocyanate and 3H-inulin. A mean blood volume of 47 ml/kg, a thiocyanate space of 350 ml/kg and a inulin space of 288 ml/kg were determined in the rat. The corresponding values of organs are shown in figures 1--3.
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation.
2022
Stop mutations cause 11% of the genetic diseases, due to the introduction of a premature termination codon (PTC) in the mRNA, followed by the production of a truncated protein. A promising therapeutic approach is the suppression therapy by Translational Readthrough Inducing Drugs (TRIDs), restoring the expression of the protein. Recently, three new TRIDs (NV848, NV914, NV930) have been proposed, and validated by several in vitro assays, for the rescue of the CFTR protein, involved in Cystic Fibrosis disease. In this work, an acute toxicological study for the three TRIDs was conducted in vivo on mice, according to the OECD No.420 guidelines. Animals were divided into groups and treated with …
Strategies for Including Patients Recruited During Interim Analysis of Clinical Trials
2007
In clinical trials a periodical check of safety and efficacy data is often needed. For organizational reasons it is rarely desirable to stop a trial during such an interim analysis. Therefore, new study patients are included in the trial while the interim analysis is ongoing. Disregarding the additional information provided by these interim patients would be unsatisfactory, especially for an office of regulatory affairs. Consequently, the rules for group sequential or adaptive decisions must be adjusted to the recruitment of interim patients. In this paper, two strategies for modifying study designs to consider the analysis of interim patients are proposed.
Analytical procedure elaboration of total flavonoid content determination and antimicrobial activity of bee bread extracts
2019
Sixteen ethanolic extracts were obtained from seven different bee bread samples. The total flavonoid content in the extracts was determined by aluminium-chloride method and was in the range of 8.3 mg/L ± 6.24% to 195.3 mg/L ± 1.35% and 28.8 mg/L ± 19.33% to 603.3 mg/L ± 4.64% with reference to quercetin and rutin, respectively. The relative standard deviations (RSD) for parallel measurements for the calibration curves of quercetin dehydrate and rutin trihydrate were in the range of 0.51% to 9.39% and 5.02% to 19.91%, respectively. The RSD for parallel measurements for the extracts with reference to quercetin dihydrate and rutin trihydrate were in the range of 0.23% to 11.64% and 4.64% to 19…
A quantitative method of photoadsorption determination for irradiated catalyst in liquid–solid system
2009
WOS: 000266963000002