Search results for "TERT"

Tuula Rotkon Susi ja surupukuinen nainen tekstien dialogissa

2001

Vapautetut sankarit : myyttirevisiot Jeanette Wintersonin romaaneissa Sexing the Cherry ja Weight

2011

Tutkielman aiheena on myyttirevisiot Jeanette Wintersonin romaaneissa Sexing the Cherry (1989) ja Weight (2005). Käsitteellä ”myyttirevisio” tarkoitetaan tutkielmassa postmoderneja, uudelleenkirjoitettuja versioita antiikin Kreikan myyteistä. Tarkasteltavat romaanit ovat rajautuneet Wintersonin romaanituotannosta tutkielman aineistoksi, sillä kyseisissä romaaneissa Winterson uudelleenkirjoittaa klassisia myyttejä siten, että luoduissa myyttirevisioissa esitetään suhteellisen yksityiskohtainen kerronnallinen paralleeli intertekstinä toimivalle myytille sekä ulotetaan kriittinen uudelleen tarkastelu myös myyttien taustalla toimiviin kulttuurisiin, ideologisiin ja poliittisiin konteksteihin. T…

Sankareita ja tarinoita : kalevalaiset henkilöhahmot Johanna Sinisalon romaanissa Sankarit

2009

Frauen/Texte : intertextuelle Funktionen der "Häutungen" von Verena Stefan in Peter Handkes Erzählung "Die linkshändige Frau"

2001

Implications of the identity position for dual career construction: Gendering the pathways to (Dis)continuation

2021

Objectives To examine how gender functions in the narrative construction of dual career styles, and how these styles impact the (dis)continuation of a dual career pathway. Design Longitudinal qualitative study. Method Life story interviews with 18 talented Finnish athletes (10 cis women, 8 cis men) at four points in time – when they averaged 16, 17, 19, and 20 years of age – followed by an integrative narrative-discursive analysis. Results (a) contrapuntal style was gender-typically female; (b) monophonic style was gender-typically male; and (c) dissonant style was an important pathway to dual career discontinuation through which gender ideologies impacted the emergent adults with different…

Impi Agafiinan myyttinen matka : sankarimyytin parodia Rosa Liksomin romaanissa Kreisland

2001

: Russell Banks, Raymond Carver, David Cronenberg, Bret Easton Ellis, David Lynch

2008

The use of the French adjective “malsain” (usually translated in English as “unhealthy,” “unwholesome” or “sick”) to judge a work of art has led me to question the relevance of this metaphor, the way this value is determined, the reasons which lead the subject to consume shocking material and the possibility to distinguish art from mere symptom. I consider the unhealthy, on the one hand, as a relation of transmission which produces an aesthetic based on metaphor and metonymy, and on the other, as a subjective value delivered by a self or a law, and I argue that, as it is entirely discursive, the unhealthy is in effect an uncanny metonymy. I show that the works under study represent and cond…

The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer

2021

Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here, we present a general optimization procedure for finding the most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated LC-18 (LC-18t) aptamer LC-18t was developed. A three-dimensional (3D) shape of LC-18t was reported based on small-angle X-ray scattering…

Appropriateness of surgery performed for abdominal aortic aneurysm at tertiary hospitals in Spain

2021

Background: The aim of this study was to analyze the appropriateness of the type of repair (open or endovascular) performed for abdominal aortic aneurysm (AAA) in five university hospitals in Spain, according to evidence-based recommendations. Methods: A multicenter, retrospective cross-sectional study of patients with AAA who underwent elective open surgical repair (OSR) or endovascular aneurysm repair (EVAR). Data were collected on demographic and clinical variables and type of surgical repair. A pair of vascular surgeons from each participating hospital performed a blinded assessment based on GRADE recommendations. The concordance between the two evaluators and the agreement between thei…

[60]Fullerene l -Amino Acids and Peptides: Synthesis under Phase-Transfer Catalysis Using a Phosphine–Borane Linker. Electrochemical Behavior

2017

International audience; A new method to link amino acid and peptide derivatives to [60]fullerene is described. It uses hydrophosphination with a secondary phosphine borane. First, the stereoselective synthesis of secondary phosphine borane amino acid derivatives was achieved by alkylation of phenylphosphine borane with gamma-iodo-alpha-amino ester reagents under phase transfer catalysis (PTC). Second, a sec-phosphine borane amino ester was saponified and coupled with alpha,gamma-diamino esters to afford the corresponding dipeptide derivatives in good yields. Finally, the hydrophosphination reaction of [60]fullerene by the sec-phosphine borane compounds was performed under PTC to obtain C-60…