Search results for "TERT"
showing 10 items of 1210 documents
Comparative genomics and protein domain graph analyses link ubiquitination and RNA metabolism.
2006
The human gene parkin, known to cause familial Parkinson disease, as well as several other genes, likely involved in other neurodegenerative diseases or in cancer, encode proteins of the RBR family of ubiquitin ligases. Here, we describe the structural diversity of the RBR family in order to infer their functional roles. Of particular interest is a relationship detected between RBR-mediated ubiquitination and RNA metabolism: a few RBR proteins contain RNA binding domains and DEAH-box RNA helicase domains. Global protein domain graph analyses demonstrate that this connection is not RBR-specific, but instead many other proteins contain both ubiquitination and RNA-related domains. These protei…
Serious Games for Health and Safety Training
2011
EUROSTAT figures show that 5720 people die in the European Union every year as a consequence of work-related accidents. Training in Health and Safety is indeed a key aspect to reduce this figure, and serious games constitute an effective method to provide this training. However, the development of this type of computer applications is a complex issue, requiring cross discipline knowledge on different areas, including instructional design, psychology, sociology, law, and computer graphics. Beyond the challenges already present in the development of non-educational computer games, serious games for health and safety are instructional tools. Therefore, they require an instructional design to c…
Identifying the combinations of motivations and emotions for creating satisfied users in SNSs: An fsQCA approach
2020
Social Networking Sites (SNSs) play an important role in our daily lives and the number of their users increases regularly. To understand how users can be satisfied in the complex digital environment of SNSs, this study examines how motivations and emotions combine with each other to explain high satisfaction. Users’ motivations comprise four attributes, entertainment, information, social-psychological, and convenience. Emotions are divided into their two main categories, that is positive and negative emotions. We draw on complexity and configuration theories, present a conceptual model along with propositions and perform a fuzzy-set qualitative comparative analysis (fsQCA). Through an empi…
Compression-based classification of biological sequences and structures via the Universal Similarity Metric: experimental assessment.
2007
Abstract Background Similarity of sequences is a key mathematical notion for Classification and Phylogenetic studies in Biology. It is currently primarily handled using alignments. However, the alignment methods seem inadequate for post-genomic studies since they do not scale well with data set size and they seem to be confined only to genomic and proteomic sequences. Therefore, alignment-free similarity measures are actively pursued. Among those, USM (Universal Similarity Metric) has gained prominence. It is based on the deep theory of Kolmogorov Complexity and universality is its most novel striking feature. Since it can only be approximated via data compression, USM is a methodology rath…
Genre of an Academic Lecture
2016
AbstractThe lecture is one of the most common forms of instruction in universities throughout the world being used as a form of studies, with the aim of conveying knowledge to a large number of students. The article looks at the nature of the academic lecture genre, its specific characteristics in comparison to other types of written or spoken modes of different genres. It introduces key theories of Genre Schools, such as New Rhetoric Studies, Systemic Functional Linguistics and English for Specific Purposes, explores the peculiarities of the university lecture as a separate genre, looks at its structure and studies the characteristic features.
Intertwining operators between different Hilbert spaces: connection with frames
2009
In this paper we generalize a strategy recently proposed by the author concerning intertwining operators. In particular we discuss the possibility of extending our previous results in such a way to construct (almost) isospectral self-adjoint operators living in different Hilbert spaces. Many examples are discussed in details. Many of them arise from the theory of frames in Hilbert spaces, others from the so-called g-frames.
The motivational appeal of interactive storytelling: Towards a dimensional model of the user experience
2009
A conceptual account to the quality of the user experience that interactive storytelling intends to facilitate is introduced. Building on socialscientific research from `old' entertainment media, the experiential qualities of curiosity, suspense, aesthetic pleasantness, self-enhancement, and optimal task engagement ("flow") are proposed as key elements of a theory of user experience in interactive storytelling. Perspectives for the evolution of the model, research and application are briefly discussed.
EFECTIVIDAD DE LAS COMUNIDADES DE APRENDIZAJE EN LA INCLUSIÓN EDUCATIVA Y SOCIAL. UNA REVISIÓN SISTEMÁTICA
2022
Las Comunidades de Aprendizaje (CdA) son un proyecto implementado en numerosos países cuya finalidad es mejorar el rendimiento del alumnado y promover la inclusión a través de la implicación de los familiares en los centros, los grupos interactivos, las tertulias literarias dialógicas, la organización del profesorado y de los recursos del centro y el mantenimiento de altas expectativas para todo el alumnado. Este trabajo revisa 16 artículos empíricos publicados en las dos últimas décadas en torno a la efectividad de las CdA. Concretamente se analizan las características de los participantes, la metodología, los instrumentos de cada estudio. Las conclusiones apuntan a un incremento del rendi…
Local Interactions and the Global City Metropolization in Warsaw
2002
A number of the world's large cities are taking on increasing economic importance in the international arenas because they concentrate high-order activities This metropolization process is a result of the changes occurring in the emerging post-industrial economy, i.e. the rise of services and information. It is based on the combination of proximity interactions and global interactions and it is characterized both by a specific internal spatial pattern and by a large outside area of influence. Since the transition period, services, and particularly high-order services, have grown more rapidly in Poland than in EU countries, as if a catching-up process has been underway. A large part of these…
Properties of trialkylamines as catalysts of resoles synthesis
2000
A series of the syntheses of phenol–formaldehyde resoles was carried out in the presence of trimethyl-, triethyl-, tripropyl-, and tributylamines and sodium hydroxide as catalysts for this process. The rate constants were calculated for the partial reactions identified in the synthesis. Also, the performance properties of the resins obtained and the hardened resin samples were estimated in simple tests. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 898–902, 2000