Search results for "TERT"
showing 10 items of 1210 documents
Testing the effects of temporal data resolution on predictions of the effects of climate change on bivalves
2014
a b s t r a c t The spatial-temporal scales on which environmental observations are made can significantly affect our perceptions of ecological patterns in nature. Understanding potential mismatches between environmen- tal data used as inputs to predictive models, and the forecasts of ecological responses that these models generate are particularly difficult when predicting responses to climate change since the assumption of model stationarity in time cannot be tested. In the last four decades, increases in computational capacity (by a factor of a million), and the evolution of new modeling tools, have permitted a corresponding increase in model complexity, in the length of the simulations,…
Seneca on the Nature of Things: Moral Concerns and Theories of Matter in Natural Questions 6
2017
It is generally recognized that Lucretius' treatment of earthquakes and pestilences (6.535-607; 1090-1286) exerted great influence on Book 6 of Seneca's Natural Questions. But while a large consensus exists that both authors tend to emphasize the moral value of scientific knowledge, further research is needed with respect to Seneca's “technical” re-use of Epicurean physics and meteorology. In the present paper, I shall address this issue in three stages. First, I will analyze the structure and intellectual goals of Seneca's “doxographic” review of seismological theories (6.5-20). Far from being a doxographic account sensu proprio, such a careful review constructs the inspiring image of an i…
Interaction of the Vibrio cholerae cytolysin (VCC) with cholesterol, some cholesterol esters, and cholesterol derivatives: a TEM study.
2002
The Vibrio cholerae cytolysin (VCC) 63-kDa monomer has been shown to interact in aqueous suspension with cholesterol microcystals to produce a ring/pore-like heptameric oligomer approximately 8 nm in outer diameter. Transmission electron microscopy data were produced from cholesterol samples adsorbed to carbon support films, spread across the holes of holey carbon films, and negatively stained with ammonium molybdate. The VCC oligomers initially attach to the edge of the stacked cholesterol bilayers and with increasing time cover the two planar surfaces. VCC oligomers are also released into solution, with some tendency to cluster, possibly via the hydrophobic membrane-spanning domain. At th…
Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions.
2008
Abstract Replacement of aspartic acid by alanine at position 265 (D265A) in mouse IgG1 results in a complete loss of interaction between this isotype and low-affinity IgG Fc receptors (FcγRIIB and FcγRIII). However, it has not yet been defined whether the D265A substitution could exhibit similar effects on the interaction with two other FcγR (FcγRI and FcγRIV) and on the activation of complement. To address this question, 34-3C anti-RBC IgG2a and IgG2b switch variants bearing the D265A mutation were generated, and their effector functions and in vivo pathogenicity were compared with those of the respective wild-type Abs. The introduction of the D265A mutation almost completely abolished the…
Oligomerization and hemolytic properties of the C-terminal domain of pyolysin, a cholesterol-dependent cytolysin
2013
Pyolysin (PLO) belongs to the homologous family of the cholesterol- dependent cytolysins (CDCs), which bind to cell membranes containing cholesterol to form oligomeric pores of large size. The CDC monomer structure consists of 4 domains. Among these, the C-terminal domain 4 has been implicated in membrane binding of the monomer, while the subsequent processes of oligomerization and membrane insertion have primarily been assigned to other domains of the molecule. Recombinantly expressed or proteolytic fragments that span domain 4 of the CDCs streptolysin O and perfringolysin O bind to membranes but fail to oligomerize, and they inhibit the activity of the respective wild-type toxins. We repo…
Barriers to Sport Participation Faced by Ethiopian and Eritrean Migrant Women in Switzerland
2021
Global migration (both forced and voluntary) has intensified the interaction between existing and emerging cultures. Sport has gained recognition as an effective tool for enhancing migrants’ overall wellbeing, active participation, and social integration. However, a growing number of studies have shown that migrant women have the lowest rate of sport participation, especially in organized clubs. These findings have brought the accessibility and inclusion of existing sport structure and culture in host countries into question. Using the six-factor model of constraints by Tsai and Coleman (1999), this study explored the barriers that hinder Ethiopian and Eritrea migrant women (EEMW) from part…
Scientific ethos and the cinematic zombie outbreak : science in fictional narratives
2015
Public anxiety about emerging biothreats is evident in the recent glut of popular entertainment where the demise, or near demise, of humankind is imagined to be the result of a new infectious pathogen against which science has no existing vaccine or cure. This article examines the figure of the scientist in such fictional narratives and what these characterizations indicate about public attitudes toward science in our contemporary world. It focuses in particular on the image of the scientist as clumsy naïve, immoral experimenter, heroic savior, and self-reflexive ethical agent.
Towards a Game-Design Framework for Evidence-Based Clinical Procedure Libraries
2019
Serious games have been and currently are used for multiple purposes other than just entertainment, such as education, healthcare or emergency management. This research presents game-design elements based on specific functional and professional requirements among which usability plays a key role. The aim of the research is to steer the direction towards a game-design framework for evidence-based clinical procedure libraries (eCPL). For context analysis and game-element presentation, a "serious application" example is shown to illustrate the improvement through game-design elements. A context analysis was required to select suitable game-design elements to target system usability and solve s…
Menores que Maltratan a sus Progenitores: definición Integral y su Ciclo de Violencia
2017
Dentro del maltrato familiar, la violencia filio-parental es una línea de investigación en el ámbito de la psicología y la pedagogía de cierta relevancia actual. En la primera parte del artículo se pretende analizar este fenómeno, desde las perspectivas psicoeducativa y jurídica, para aportar una definición integral que abarque diferentes perspectivas de la violencia filio-parental, porque la intervención y prevención de ésta debe partir del conocimiento acerca de las causas y mecanismos que intervienen en el complejo ámbito de ésta violencia intrafamiliar, así como de las relaciones e interacciones que se establecen entre hijos, hijas y progenitores. Por ello, la segunda parte del artículo…
Yeast Cell Wall Glycoproteins
1991
In higher cells, glycoproteins play a variety of functions as surface receptors, cell-cell mediators, carriers of enzyme activities, components of the extracellular matrix, etc. In most glycoproteins, the protein moiety will be the functional part whereas the carbohydrate moiety would contribute to the attainment of an adequate tertiary structure, modify the glycoprotein molecule making it more resistant to degradation, and facilitate its secretion.