Search results for "TERT"

A statistical approach towards a regionalization of daily rainfall in Sri Lanka

1993

Regionalization of daily rainfall in Sri Lanka was examined using orthogonal factor analysis (OFA) based on daily rainfall data of 42 stations for a 15-year period (1971–1985). The number of potential rainy days was computed from the original data matrix and subjected to S-mode OFA. The first 10 orthogonal factors were shown as highly significant, explaining 65.1 per cent of the total variance of the whole data matrix, where the level of eigenvalues represented was > 1.0. Noticeably, the 10 orthogonal factors clearly revealed the different homogeneous daily rainfall regions in Sri Lanka (labelled as A to J), according to the orthogonal factor high loadings matrix. Delimitation of the daily …

Testing Measurement Invariance of Hedonic and Eudaimonic Entertainment Experiences Across Media Formats

2016

ABSTRACTThe aim of this study is to investigate the measurement invariance of media users’ entertainment experiences as conceptualized by two-process models of entertainment (i.e., enjoyment and appreciation) across different media formats. With this purpose, the present research relates to the recent rise of entertainment research, embracing more and more media types and formats with which entertainment experiences may occur. At the same time, it addresses a methodological issue that has rarely been addressed in communication research. Focusing on one of the most often used measurement instruments in entertainment research, on three different media formats (political talk shows, comedies, …

Workload Characterization in Multiplayer Online Games

2006

In recent years, distributed virtual environments (DVEs) have become a major trend in distributed applications, mainly due to the enormous popularity of multiplayer online games in the entertainment industry. Although the workload generated by avatars in a DVE system has already been characterized, the special features of multiplayer online games make these applications to require a particular workload characterization. This paper presents the workload characterization of multiplayer online games. This characterization is based on real traces, and it shows that the movement patterns of avatars used to develop optimization techniques for DVE systems can be extrapolated to First Person Shooti…

Providing Full Awareness to Distributed Virtual Environments Based on Peer-to-Peer Architectures

2006

In recent years, large scale distributed virtual environments (DVEs) have become a major trend in distributed applications, mainly due to the enormous popularity of multiplayer online games in the entertainment industry. Since architectures based on networked servers seems to be not scalable enough to support massively multiplayer applications, peer-to-peer (P2P) architectures have been proposed as an efficient and truly scalable solution for this kind of systems. However, the main challenge of P2P architectures consists of providing each avatar with updated information about which other avatars are its neighbors. We have denoted this problem as the awareness problem. Although some proposal…

Mutational analysis of the RNA-binding domain of the Prunus necrotic ringspot virus (PNRSV) movement protein reveals its requirement for cell-to-cell…

2005

AbstractThe movement protein (MP) of Prunus necrotic ringspot virus (PNRSV) is required for cell-to-cell movement. MP subcellular localization studies using a GFP fusion protein revealed highly punctate structures between neighboring cells, believed to represent plasmodesmata. Deletion of the RNA-binding domain (RBD) of PNRSV MP abolishes the cell-to-cell movement. A mutational analysis on this RBD was performed in order to identify in vivo the features that govern viral transport. Loss of positive charges prevented the cell-to-cell movement even though all mutants showed a similar accumulation level in protoplasts to those observed with the wild-type (wt) MP. Synthetic peptides representin…

Changes in protein domains outside the catalytic site of the bacteriophage Qβ replicase reduce the mutagenic effect of 5-azacytidine.

2014

ABSTRACT The high genetic heterogeneity and great adaptability of RNA viruses are ultimately caused by the low replication fidelity of their polymerases. However, single amino acid substitutions that modify replication fidelity can evolve in response to mutagenic treatments with nucleoside analogues. Here, we investigated how two independent mutants of the bacteriophage Qβ replicase (Thr210Ala and Tyr410His) reduce sensitivity to the nucleoside analogue 5-azacytidine (AZC). Despite being located outside the catalytic site, both mutants reduced the mutation frequency in the presence of the drug. However, they did not modify the type of AZC-induced substitutions, which was mediated mainly by …

The external domains of the HIV-1 envelope are a mutational cold spot

2015

In RNA viruses, mutations occur fast and have large fitness effects. While this affords remarkable adaptability, it can also endanger viral survival due to the accumulation of deleterious mutations. How RNA viruses reconcile these two opposed facets of mutation is still unknown. Here we show that, in human immunodeficiency virus (HIV-1), spontaneous mutations are not randomly located along the viral genome. We find that the viral mutation rate experiences a threefold reduction in the region encoding the most external domains of the viral envelope, which are strongly targeted by neutralizing antibodies. This contrasts with the hypermutation mechanisms deployed by other, more slowly mutating …

BIOGEOGRAPHY OF TERTIARY PRIMATES: DISCUSSION OF AN UPDATED DATABASE

2009

Biogeography of Tertiary Primates: Discussion over an updated Data Base

2009

A preliminary taxonomic evaluation of the Tertiary Primate fossil record of the Old World is presented. The dataset has been compiled using the information and the structure presented by the NOW database (Neogene Mammalian of the Old World; Academy of Finland, 2007), strongly updated with the additional information derived from different literature sources. A quantitative methodology for compilation and analysis of the data has been applied following the methodology described in Petruso et al. (2008). The adopted numerical treatment of data is particularly effective in synthesizing and analyzing the large amount of information contained in the data set. This analysis gives a synthetic pictu…

High-resolution records of growth temperature and life history of two Nacella limpet species, Tierra del Fuego, Argentina

2020

Stable isotope ratios in patelloid limpets of the genus Patella have been established as proxies for coastal environmental change at sub-monthly resolution along the eastern North Atlantic and Mediterranean Sea. Nacella deaurata (Gmelin, 1791) and N. magellanica (Gmelin, 1791) are common intertidal species of patelloid limpets inhabiting the coast of Tierra del Fuego, Argentina/Chile and are commonly found in Holocene archaeological deposits. Here, we examine oxygen and carbon isotope ratios (δ18Oshell and δ13Cshell, respectively) of modern specimens of N. deaurata and N. magellanica to test the hypotheses that: 1) they form their shells in isotopic equilibrium with ambient water; and 2) pr…