Search results for "TERT"

An Emphatic Humanoid Robot with Emotional Latent Semantic Behavior

2008

In this paper we propose an Entertainment Humanoid Robot model based on Latent Semantic Analysis, that tries to exhibit an emotional behavior in the interaction with human. Latent Semantic Analysis (LSA), based on vector space allows the coding of the words semantics by specific statistical computations applied to a large corpus of text. We illustrate how the creation and the use of this emotional conceptual space can provide a framework upon which to build “Latent Semantic Behavior” because it simulates the emotionalassociative capabilities of human beings. This approach integrates traditional knowledge representation with intuitive capabilities provided by geometric and sub-symbolic infor…

2020

Background Digital gaming is one of the most popular forms of entertainment in the world. While prior literature concluded that digital games can enable changes in players’ behaviors, there is limited knowledge about different types of behavior changes and the game features driving them. Understanding behavior changes and the game features behind them is important because digital games can motivate players to change their behavior for the better (or worse). Objective This study investigates the types of behavior changes and their underlying game features within the context of the popular pervasive game Pokémon GO. Methods We collected data from 262 respondents with a critical incident tech…

Itaque conabor opus versibus pandere, tra prosa e poesia. Percorsi intertestuali nei Satyrica

2010

Contributi scientifici sul testo del Satyricon, relativi sia a parti in poesia, sia a parti in prosa.

Capillorum elegidarion (Petr. 109, 9-10)

2010

Interpretazione del controverso componimento in distici elegiaci e in falecei vertente sulla persita della chioma nei Satyrica di Petronio

3D-QSAR pharmacophore modeling and in silico screening of new Bcl-xl inhibitors.

2010

Bcl-2 proteins family members play several roles in tumoral proliferation: they inhibit proapoptotic activity during oncogenesis, support tumor cells survival, induce chemoresistance. The discovery of new small inhibitors of Bcl-xl represents a new frontier for cancer treatment. In this study, a 3D-QSAR pharmacophore model was developed, based on 42 biarylacylsulfonamides, and used to understand the structural factors affecting the inhibitory potency of these derivatives. Aromatic, negative charge, and hydrogen bond acceptor effects contribute to the inhibitory activity. The model was then employed as 3D search query to screen ZINC drug-like database in order to select new scaffolds. Finall…

New Hypolipaemic Agents Designed by Molecular Topology: Pharmacological Studies of 2,6-Di-tert-butyl-4-methylpyridine and 2,6-Di-tert-butylpyridine

1999

New compounds showing hypolipaemic activity have been designed using a computer-aided method based on molecular topology and QSAR analysis. Linear discriminant analysis and connectivity functions were used to design three potentially suitable drugs which were tested for hypolipaemic properties by the Triton WR-1339 test in rats. The pharmacological tests carried out on the newly designed compounds demonstrated the existence of notable activity in phase I for two of them. namely 2,6-Di-tert-butyl-4-methylpyridine (C.A.S. 38222-83-2) and 2,6-Di-tert-butylpyridine (C.A.S. 585-48-8), with respect to the level of total cholesterol. Both substances decrease the lipaemia to lower levels than clofi…

Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

2007

This review describes simple and useful concepts for predicting and tuning the pK(a) values of basic amine centers, a crucial step in the optimization of physical and ADME properties of many lead structures in drug-discovery research. The article starts with a case study of tricyclic thrombin inhibitors featuring a tertiary amine center with pK(a) values that can be tuned over a wide range, from the usual value of around 10 to below 2 by (remote) neighboring functionalities commonly encountered in medicinal chemistry. Next, the changes in pK(a) of acyclic and cyclic amines upon substitution by fluorine, oxygen, nitrogen, and sulfur functionalities, as well as carbonyl and carboxyl derivativ…

The Philippines 2017 : Duterte-led Authoritarian Populism and Its Liberal-Democratic Roots

2017

Philippine President Rodrigo Duterte led a phenomenal campaign to win the 2016 national election. During his first two years in power Duterte has become the protagonist and exemplar of a key new development – the social formation of a regime of authoritarian populism. Based on an analysis of news reports, public debates, survey results, and official policy documents from 2017, the article examines various features of this emergent regime and then illuminates the historical-institutional mechanisms that brought it about. The inquiry is predicated on an understanding that the old EDSA Republic’s liberal-democratic regime has been marked by intractable socio-economic crises since its installat…

UNESCO’s cinematic multiverse and the best of all possible worlds

2020

Sigmund Freud et l’hypnose : une histoire complexe

2008

L’hypnose fut l’une des premieres methodes therapeutiques utilisee par Sigmund Freud. Il est souvent affirme qu’il s’en detourna, afin de bâtir la psychanalyse, et qu’il trouvait l’hypnose insatisfaisante. Nous etudions ici l’evolution des rapports entre Freud et l’hypnose, et montrons que sa position etait pour le moins complexe et ambivalente. Freud l’utilisait au moins jusqu’en 1924, et ne cessa de s’interroger a son propos.