Search results for "TERT"

Baltic Journal of English Language, Literature and Culture, N. 3

2013

Single amino acids in the lumenal loop domain influence the stability of the major light-harvesting chlorophyll a/b complex.

2004

The major light-harvesting complex of photosystem II (LHCIIb) is one of the most abundant integral membrane proteins. It greatly enhances the efficiency of photosynthesis in green plants by binding a large number of accessory pigments that absorb light energy and conduct it toward the photosynthetic reaction centers. Most of these pigments are associated with the three transmembrane and one amphiphilic alpha helices of the protein. Less is known about the significance of the loop domains connecting the alpha helices for pigment binding. Therefore, we randomly exchanged single amino acids in the lumenal loop domain of the bacterially expressed apoprotein Lhcb1 and then reconstituted the muta…

Influence of dispersion on the resonant interaction between three incoherent waves

2005

We study the influence of group-velocity dispersion (or diffraction) on the coherence properties of the parametric three-wave interaction driven from an incoherent pump wave. We show that, under certain conditions, the incoherent pump may efficiently amplify a signal wave with a high degree of coherence, in contrast with the usual kinetic description of the incoherent three-wave interaction. The group-velocity dispersion is shown to be responsible for a spectral filtering process, in which the coherence of the generated signal increases, as the coherence of the pump wave decreases. As a result, the coherence acquired by the signal in the presence of an incoherent pump, is higher than that a…

Quons, coherent states and intertwining operators

2009

We propose a differential representation for the operators satisfying the q-mutation relation $BB^\dagger-q B^\dagger B=\1$ which generalizes a recent result by Eremin and Meldianov, and we discuss in detail this choice in the limit $q\to1$. Further, we build up non-linear and Gazeau-Klauder coherent states associated to the free quonic hamiltonian $h_1=B^\dagger B$. Finally we construct almost isospectrals quonic hamiltonians adopting the results on intertwining operators recently proposed by the author.

Non-isospectral Hamiltonians, intertwining operators and hidden hermiticity

2011

We have recently proposed a strategy to produce, starting from a given hamiltonian $h_1$ and a certain operator $x$ for which $[h_1,xx^\dagger]=0$ and $x^\dagger x$ is invertible, a second hamiltonian $h_2$ with the same eigenvalues as $h_1$ and whose eigenvectors are related to those of $h_1$ by $x^\dagger$. Here we extend this procedure to build up a second hamiltonian, whose eigenvalues are different from those of $h_1$, and whose eigenvectors are still related as before. This new procedure is also extended to crypto-hermitian hamiltonians.

Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis

2013

Bax Inhibitor-1 (BI-1) is an evolutionarily conserved six-transmembrane domain endoplasmic reticulum (ER)-localized protein that protects against ER stress-induced apoptotic cell death. This function is closely connected to its ability to lower steady-state ER Ca2+ levels. Recently, we elucidated BI-1's Ca(2+)-channel pore in the C-terminal part of the protein and identified the critical amino acids of its pore. Based on these insights, a Ca(2+)-channel pore-dead mutant BI-1 (BI-1(D213R)) was developed. We determined whether BI-1 behaves as a bona fide H+/Ca2+ antiporter or as an ER Ca(2+)-leak channel by investigating the effect of pH on unidirectional Ca(2+)-efflux rates. At pH 6.8, wild-…

Thermostability of Two Cyanobacterial GrpE Thermosensors

2011

GrpE proteins act as co-chaperones for DnaK heat-shock proteins. The dimeric protein unfolds under heat stress conditions, which results in impaired interaction with a DnaK protein. Since interaction of GrpE with DnaK is crucial for the DnaK chaperone activity, GrpE proteins act as a thermosensor in bacteria. Here we have analyzed the thermostability and function of two GrpE homologs of the mesophilic cyanobacterium Synechocystis sp. PCC 6803 and of the thermophilic cyanobacterium Thermosynechococcus elongatus BP1. While in Synechocystis an N-terminal helix pair of the GrpE dimer appears to be the thermosensing domain and mainly mediates GrpE dimerization, the C-terminal four-helix bundle i…

ASV un Pakistānas sadarbība terorisma apkarošanā (2001-2014)

2015

ASV un Pakistānas sadarbība terorisma apkarošanā, sniedz ārkārtīgi būtisku informāciju gan attiecībā uz sasniegto pretterorisma jomā, gan attiecībā uz iespējamajiem trūkumiem pretterorisma stratēģijās. Lai gan abu valstu attiecības raksturo abpusēja neuzticēšanās, ASV vadītā pretterorisma cīņa būtu neiespējama bez Pakistānas kā reģiona sabiedrotā. Šobrīd ir skaidrs, ka abu valstu sadarbībā nav sasniegti cerētie rezultātus, bet lai identificētu sadarbības neizdošanās iemeslus ir nepieciešama padziļināta pretterorisma sadarbības izpēte. Lai izvērtētu sadarbību pretterorisma centienos, darba ietvaros tiek aplūkoti abu valstu īstenotie pretterorisma pasākumi, kā arī analizētas pretterorisma pol…

Stimuli-Responsive Tertiary Amine Functional PEGs Based on N,N-Dialkylglycidylamines

2014

Amine-functional poly(ethylene glycol) (PEG) copolymers have been prepared that exhibit thermo- and pH- responsive behavior in aqueous solution. Three novel tertiary di(n-alkyl)glycidylamine monomers have been introduced for anionic ring-opening copolymerization (AROcP) with ethylene oxide (EO): N,N-di(n-butyl)glycidylamine (DButGA), N,N-di(n-hexyl)glycidylamine (DHexGA), and N,N-di(n-octyl)glycidylamine (DOctGA). Via controlled AROcP we synthesized well-defined (Mw/Mn = 1.05–1.14), water-soluble block- and gradient-type PEG copolymers, containing up to 25 mol % of the respective dialkylglycidylamine comonomer. Molecular weights ranged from 4900 to 12 000 g mol–1. Detailed in-situ 1H NMR ki…

Synthesis of Novel Folic Acid-Functionalized Biocompatible Block Copolymers by Atom Transfer Radical Polymerization for Gene Delivery and Encapsulati…

2005

Two synthetic routes to folic acid (FA)-functionalized diblock copolymers based on 2-(methacryloyloxy)- ethyl phosphorylcholine [MPC] and either 2-(dimethylamino)ethyl methacrylate [DMA] or 2-(diisopropylamino) ethyl methacrylate [DPA] were explored. The most successful route involved atom transfer radical polymerization (ATRP) of MPC followed by the tertiary amine methacrylate using a 9-fluorenylmethyl chloroformate (Fmoc)-protected ATRP initiator. Deprotection of the Fmoc groups produced terminal primary amine groups, which were conjugated with FA to produce two series of novel FA-functionalized biocompatible block copolymers. Nonfunctionalized MPC-DMA diblock copolymers have been previou…