Search results for "TESTOSTERONE"
showing 10 items of 420 documents
SENSITIZED LANTHANIDE FLUORESCENCE DETECTION OF STEROIDAL HORMONES
2000
Several steroidal hormones with an α,β-unsaturated carbonyl group sensitized the fluorescence of terbium(III) ions: medroxyprogesterone, medroxyprogesterone acetate, methyltestosterone, nandrolone, nandrolone decanoate, progesterone, testosterone, testosterone enanthate, and testosterone propionate, but other steroids which have this chromophore did not give any signal: clostebol acetate, dehydrotestosterone, dydrogesterone, methandienone, and methenolone enanthate. Sensitized fluorescence was used to detect the steroids when eluted with micellar mobile phases of sodium dodecyl sulphate (SDS)-acetonitrile and SDS-pentanol containing 0.01 M Tb(III), with 245 nm and 545 nm as excitation and e…
A research on the action of testosterone propionate and of ciproterone acetate on the mouse-killing behaviour of the adult rat.
1979
AbstractData demonstrate exactly that testosterone favour above all the killing behaviour of castrate males at birth in comparison with control males while ciproterone acetate turns out to be more effective in diminishing the killing behaviour of males having integral testicle and of androgenized females at birth in comparison with castrated males.The results point out that the killing behaviour of rats is affected by the presence of testosterone in the first days of life, and in the grown-up animal.
Evaluation of anti-androgenic activity of di-(2-ethylhexyl)phthalate
2005
International audience; DEHP is a widely used platiciser in the manufacture of PVC-based materials. It is known to disrupt the reproductive tract development in male rats. We have performed the Hershberger assay with DEHP on an immature castrated rat model to check if DEHP antagonise the testosterone propionate androgenic effect on the accessory sex organs development. DEHP significantly decreased the BC/LA muscles, the prostate, and the seminal vesicles relative weights from 100, 200, and 400 mg/kg bw/day, respectively. DEHP increased the liver relative weight from 100 mg/kg bw/day. A study was also performed on MDA-MB453 cell line stably transfected with pMMTVneo-Luc with DEHP and its maj…
Effects of chronic treatment with testosterone propionate on aggression and hormonal levels in intact male mice.
1998
Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly injections of 3.75, 7.5, 15, and 30 mg/kg of drug or sesame oil for 10 weeks. During the last 3 weeks, behavioral tests were conducted and at the end of the experiment, body, liver and testes weight and hormonal data were collected. The treatment had minimal behavioral and endocrine effects. It resulted in shorter latencies of 'threat' only in the last agonistic encounter, increases in testosterone levels and decreases in testes weight in a non-linear dose-dependant way. The action of treatment was different on threat and attack, the …
Lack of effects of anabolic-androgenic steroids on locomotor activity in intact male mice.
1999
Anabolic-androgenic steroid abusers have reported hyperactivity euphoria, and decreased fatigue, among other behavioral effects. It has been suggested that the effects of these substances on the central nervous system are similar to those of psychostimulants; however, the influence of steroids on general locomotor activity in laboratory animals is not well understood, especially how noncastrated male rodents are affected. In this study, spontaneous locomotor activity displayed by gonadally intact male mice submitted to several experimental conditions was analyzed. Different housing conditions (individual or cohabiting with a female), diverse steroids (testosterone propionate, nandrolone de…
Effects of chronic administration with high doses of testosterone propionate on behavioral and physiological parameters in mice with differing basal …
2003
The effects of testosterone propionate, an anabolic-androgenic steroid, on the behavior displayed during a social encounter by gonadally intact male mice were investigated. Animals were distributed into three groups according to their attack latency in a pre-screening test (high-, moderate-, and low-attacking mice) and each group received weekly injections of 60 or 120 mg/kg of testosterone or sesame oil for 10 weeks. Behavioral tests were then carried out. Afterwards, organs were weighed and blood samples collected in order to obtain hormonal data. Treatment had a differential impact on attack in the three groups of animals. Only the high-attacking testosterone-treated mice showed lower to…
The role of social processes and decision making on the psychobiological response to social stress
2018
Los humanos, a diario, se enfrentan a diversas interacciones sociales, que pueden ser interpretadas como retos o como amenazas en función del contexto y del individuo que las enfrenta. Es por ello, que el cuerpo humano acaba activando sus mecanismos fisiológicos y conductuales en función de cómo interpreta está situación. Durante toda esta interpretación los humanos deciden un patrón de conducta que les lleva a tomar un tipo de decisiones u otras para adaptarse a estas interacciones sociales. Es por ello que la toma de decisiones puede ser una variable de estudio importante a lo largo de toda una interacción social, tanto como decidimos en función de la interacción y la respuesta fisiológic…
Organizational and activational effects of testosterone in two populations with high androgenization susceptibility = Efectos organizadores y activad…
2013
Los esteroides sexuales como la testosterona (T) producen una organización y/o modificaciones relativamente permanentes de la estructura y función del sistema nervioso central. Una alta exposición prenatal a la T podría estar relacionada con una mayor sensibilidad a los efectos activadores de dicha hormona durante la edad adulta. Por otra parte, las fluctuaciones en los niveles endógenos de T pueden modificar transitoriamente las capacidades socio-cognitivas. Así, la conducta y los procesos cognitivos podrían ser el resultado de la interacción entre los efectos hormonales organizadores y activadores. La T podría ser considerada como un predictor de rasgos masculinizados tales como los rasgo…
High level of plasma estradiol as a new predictor of ischemic arterial disease in older postmenopausal women: the three-city cohort study.
2012
Background Despite evidence that estrogens may be involved in atherothrombosis, the role of endogenous sex steroid hormones in ischemic arterial disease among postmenopausal women remains uncertain. Methods and Results In the Three‐City prospective cohort study of subjects (n=9294) >65 years of age, we investigated the association of total 17β‐estradiol, bioavailable 17β‐estradiol, and total testosterone with the 4‐year incidence of ischemic arterial disease among postmenopausal women who did not use any hormone therapy. We designed a case–cohort study including a random sample of 537 subjects and 106 incident cases of first cardiovascular events. Weighted Cox proportional‐hazards model…
Prenatal androgen exposure modulates cellular and humoral immune function of black-headed gull chicks
2005
Avian eggs contain considerable amounts of maternal yolk androgens, which have been shown to beneficially influence the physiology and behaviour of the chick. As androgens may suppress immune functions, they may also entail costs for the chick. This is particularly relevant for colonial species, such as the black-headed gull (Larus ridibundus), in which the aggregation of large numbers of birds during the breeding season enhances the risk of infectious diseases for the hatching chick.To test the effect of maternal yolk androgens on the chick's immune function, we experimentally manipulated, in a field study, yolk androgen levels within the physiological range by in ovo injection of either a…