Search results for "TF"

showing 10 items of 1652 documents

Python valodas REST API ietvaru salīdzinājums

2016

Arvien populārāk kļūst veidot tīmekļa vietņu servera puses risinājumus, kuri balstās uz REST API arhitektūru. Šāds koncepts ļauj atdalīt datu apstrādes un manipulācijas procesu no to reprezentācijas, radot iespēju šīs funkcionalitātes izstrādāt neatkarīgi vai nodrošināt datus vairākām nesaistītām lietotnēm vienlaicīgi. Šajā darbā ir apskatīti vairāki specializēti Python programmēšanas valodas ietvari REST API sistēmu izstrādei. Darbā ir veikts gan teorētisks, gan empīrisks pētījums par esošajām iespējām, un ar vienotu funkcionalitāti izstrādāti REST API servisi ar dažādiem ietvariem. Darba rezultātā ir veikta iegūto datu analīze un formulēti secinājumi par katru no ietvariem.

Django RESTDatorzinātneRESTAPIlask-RESTfulFalcon
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Lung tumorspheres as a drug screening platform against cancer stem cells.

2019

Treatment resistance and metastasis are linked to cancer stem cells (CSCs). This population represents a promising target, but remains unexplored in lung cancer. The main objective of this study was to characterize lung CSCs and discover new therapeutic strategies.

Drugcancer stem cellsLungbusiness.industrymedia_common.quotation_subjectHematologyrespiratory systemrespiratory tract diseasesmedicine.anatomical_structureOncologyCancer stem celllung tumorspheresCancer researchmedicinebusinessdrug screening platformmedia_common
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Does Metformin Modulate Mitochondrial Dynamics and Function in Type 2 Diabetic Patients?

2021

Metformin is an effective drug against type 2 diabetes (T2D), a pathogenesis in which mitochondrial dysfunction is one of the main players. Thus, our first aim was to describe the effect of metform...

Drugendocrine system diseasesPhysiologymedia_common.quotation_subjectClinical BiochemistryInflammationType 2 diabetesBioinformaticsBiochemistryPathogenesisText miningMedicineMolecular BiologyGeneral Environmental Sciencemedia_commonbusiness.industrynutritional and metabolic diseasesCell Biologymedicine.diseaseMetforminGeneral Earth and Planetary Sciencesmedicine.symptombusinesshuman activitiesFunction (biology)medicine.drugAntioxidants & Redox Signaling
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Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Metformin Hydrochloride.

2021

Abstract Data are examined regarding possible waiver of in vivo bioequivalence testing (i.e. biowaiver) for approval of metformin hydrochloride (metformin) immediate-release solid oral dosage forms. Data include metformin's Biopharmaceutics Classification System (BCS) properties, including potential excipient interactions. Metformin is a prototypical transporter-mediated drug and is highly soluble, but only 50% of an orally administered dose is absorbed from the gut. Therefore, metformin is a BCS Class III substance. A BCS-based approval approach for major changes to marketed products and new generics is admissible if test and reference dosage forms have the identical active pharmaceutical …

Drugendocrine system diseasesmedia_common.quotation_subjectPharmaceutical ScienceExcipientAdministration OralBiological Availabilitytransporters02 engineering and technologyPharmacologyBioequivalence030226 pharmacology & pharmacyDosage formPermeabilityBiopharmaceutics03 medical and health sciencesMetformin hydrochloride0302 clinical medicinePharmacokineticsmedicineBiopharmaceutics Classification System (BCS)media_commonActive ingredientDosage FormsbioequivalenceexcipientsChemistry021001 nanoscience & nanotechnologyBiopharmaceutics Classification SystembiowaiverMetforminMetforminSolubilityTherapeutic Equivalencyregulatory science0210 nano-technologypharmacokineticsmedicine.drugJournal of pharmaceutical sciences
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Adjuncts for ovarian stimulation: when do we adopt “orphan indications” for approved drugs?

2009

Several drugs, shown to be safe for other uses, have proven to be highly effective adjuncts for ovarian stimulation. The authors evaluate these "orphan" indications and make recommendations so that more patients will benefit from their use.

Drugendocrine systemmedicine.medical_specialtyOrphan Drug ProductionResearch methodologymedia_common.quotation_subjectFertilization in VitroReproductive technologyAcide acétylsalicyliqueHealth servicesProstaglandin-Endoperoxide SynthaseOvulation InductionHumansMedicineIntensive care medicinemedia_commonGynecologyAspirinHuman Growth Hormonebusiness.industryObstetrics and GynecologyErgot DerivativesEstrogensMetforminReproductive MedicineDopamine AgonistsAndrogensFemaleFertility agentsLeuprolidebusinessContraceptives OralPolycystic Ovary SyndromeFertility and Sterility
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Elección del agente oral más apropiado, en monoterapia o en combinación, en el paciente anciano con diabetes

2010

The elderly patient with diabetes presents a series of features that we need to have in mind when considering drug therapy, such as quality of life, presence of chronic complications, major geriatric syndromes, and patient preferences. The limited evidence available due to the few studies performed in the elderly explains the limited existing recommendations in the most current clinical practice guidelines. Metformin is the drug of choice as monotherapy and its dosage should be adjusted to the degree of renal failure, a situation very common in the elderly. Other pharmacologic groups can also be used taking into account their limitations and contraindications. There is no consensus on what …

Drugmedicine.medical_specialtyCombination therapybusiness.industryEndocrinology Diabetes and MetabolismInsulinmedicine.medical_treatmentmedia_common.quotation_subjectmedicine.diseasehumanitiesMetforminRegimenPharmacotherapyQuality of lifeDiabetes mellitusInternal MedicinemedicineIntensive care medicinebusinessmedicine.drugmedia_commonAvances en Diabetología
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Populārāko e-komercijas platformu salīdzinājums un to analīze 2021.gadā

2022

Bakalaura darbā ir izpētītas un izanalizētas populārākās e-komercijas platformas – Shopify, WooCommerce un Magento. Ar reālu piemēru palīdzību lasītājam tiek dota iespēja iepazīties ar dažādām e-komercijas platformām, to iespējām un ar uzņēmumiem, kuri tās izmanto ikdienā.

E-COMMERCEE-KOMERCIJAS ANALĪZEE-KOMERCIJAS PLATFORMAEkonomika un uzņēmējdarbībaE-COMMERCE PLATFORME-KOMERCIJA
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E-Learning Experiences in La Ribera Health Department

2014

This paper shows how the training of health professionals is improving thanks to the use of new technologies, in particular e-learning. This type of technology is widely used in medical education and there are multiple research works that report its effective deployment by health professionals and students. However, there is a need to incorporate e-learning platforms and online methods in healthcare organizations through a systematic and rigorous approach what is proposed in the current work. This approach has been applied since 2009 in the context of La Ribera Health Department implementing a high number of e-learning experiences. The obtained outcomes reveal how useful have been these exp…

E-Learning PlatformsMedical educationKnowledge managementGeneral Computer Sciencebusiness.industryEmerging technologiesE-learning (theory)Professional developmentHuman ResourcesContext (language use)On-Line MethodsARQUITECTURA Y TECNOLOGIA DE COMPUTADORESHospital TrainingElectronic Medical RecordSoftware deploymentHealth careSociologybusinessHuman resourcesHealth department
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Web Services -tekniikoiden hyödyntäminen Java Platform, Micro Edition -ympäristössä

2008

EAIpalvelukeskeisyysWeb Servicesliikkuva tietojenkäsittelyJava Platform Micro EditionSOAintegraatioatk-ohjelmat
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Ilgtspējīgu finanšu ieguldījumu veiktspējas analīze.

2022

Pieaugot interesei par ilgtspējīgiem ieguldījumiem, aktīvu īpašnieki un portfeļu pārvaldnieki cenšas savu ieguldījumu procesā iekļaut vides, sociālos un pārvaldības (ESG) apsvērumus. Ieguldītājiem trūkst zināšanu, kā šos ilgtspējas faktorus iekļaut ieguldījumu portfeļa izveidē, un pastāv šaubas par to, kādu ietekmi tas atstās uz ieguldījumu veiktspēju. Maģistra darba mērķis ir novērtēt ietekmi uz akciju portfeļa ienesīguma un riska rādītājiem, ko atstāj ilgtspējas kritēriju iekļaušana portfeļa izveidē, atkarībā no izvēlētās ieguldījumu stratēģijas. Lai kvantitatīvi noteiktu uzņēmumu ilgtspējas sniegumu, tiek izmantots ESG reitings, ko piedāvā Sustainalytics. Lai iekļautu ilgtspējas kritērij…

ESGESG efektīvā robežaEkonomikaIlgtspējīgi ieguldījumiIeguldījumu portfeļu izveide
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