Search results for "TF"
showing 10 items of 1652 documents
Flexible parental care: Uniparental incubation in biparentally incubating shorebirds
2017
The relative investment of females and males into parental care might depend on the population’s adult sex-ratio. For example, all else being equal, males should be the more caring sex if the sex-ratio is male biased. Whether such outcomes are evolutionary fixed (i.e. related to the species’ typical sex-ratio) or whether they arise through flexible responses of individuals to the current population sex-ratio remains unclear. Nevertheless, a flexible response might be limited by the evolutionary history of the species, because one sex may have lost the ability to care or because a single parent cannot successfully raise the brood. Here, we demonstrate that after the disappearance of one pare…
Sensitivity of pancreatic cancer cells to chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals can be regulated by WT-TP53
2020
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic malignancy. Approximately 85% of pancreatic cancers are classified as PDACs. The survival of PDAC patients is very poor and only 5–10% of patients survive 5 years after diagnosis. Mutations at the KRAS and TP53 gene are frequently observed in PDAC patients. The PANC-28 cell line lacks wild-type (WT) TP53. In the following study, we have investigated the effects of restoration of WT TP53 activity on the sensitivity of PANC-28 pancreatic cancer cells to various drugs which are used to treat PDAC patients as well as other cancer patients. In addition, we have examined the effects of signal transduction inhibitors which tar…
The desert gerbil Psammomys obesus as a model for metformin-sensitive nutritional type 2 diabetes to protect hepatocellular metabolic damage: Impact …
2017
Introduction While metformin (MET) is the most widely prescribed antidiabetic drug worldwide, its beneficial effects in Psammomys obesus (P. obesus), a rodent model that mimics most of the metabolic features of human diabetes, have not been explored thoroughly. Here, we sought to investigate whether MET might improve insulin sensitivity, glucose homeostasis, lipid profile as well as cellular redox and energy balance in P. obesus maintained on a high energy diet (HED). Materials and methods P. obesus gerbils were randomly assigned to receive either a natural diet (ND) consisting of halophytic plants (control group) or a HED (diabetic group) for a period of 24 weeks. MET (50 mg/kg per os) was…
Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth
2019
BackgroundNutrition of the newborn during the early postnatal period seems to be of capital importance and there is clinical evidence showing the protective effect of breastfeeding compared with formula feeding on childhood obesity and its comorbidities. Infants born small for gestation age may be more sensitive to the type of feeding during lactation. Here, we aimed to analyze the impact of birth weight and the type of infant feeding on the expression levels in peripheral blood cells of selected candidate genes involved in energy homeostasis in 5-year-old children, to find out potential early biomarkers of metabolic programming effects during this period of metabolic plasticity.MethodsFort…
Sensory reweighting in frail aged adults: Are the balance deficiencies mainly compensated by visual or podal dependences?
2021
Abstract Background Postural control is based on the integration of different sensory inputs. The process of scaling the relative importance of these sensory cues (visual, vestibular and proprioceptive) depends on individuals and creates sensory preferences, leading to sensory dependences when one particular source is preponderant. In this context, the literature showed a frequent visual dependence (visual inputs weighting) in aged adults. However, the somaesthetic inputs can also be prioritised in a podal-dependent profile. In the frail aged adults, none study has shown the distribution of these two dependences. Research question Which sensory orientation profile is preferentially adopted …
Does Metformin Modulate Endoplasmic Reticulum Stress and Autophagy in Type 2 Diabetic Peripheral Blood Mononuclear Cells?
2018
Since type 2 diabetes (T2D) is associated with oxidative stress and metformin has been shown to exert a protective role against the said stress, we wondered whether metformin treatment might also modulate endoplasmic reticulum (ER) stress and autophagy in leukocytes of T2D patients. We studied 53 T2D patients (37 of whom had been treated with metformin 1700 mg for at least 1 year) and 30 healthy volunteers. Leukocytes from both groups of T2D patients exhibited increased protein levels of 78-kDa glucose-regulated protein (GRP78) with respect to controls, whereas activating transcription factor 6 (ATF6) was enhanced specifically in nonmetformin-treated T2D, and (s-xbp1) and phosphorylated euk…
Investigating the Vascular Toxicity Outcomes of the Irreversible Proteasome Inhibitor Carfilzomib
2020
Background: Carfilzomib&rsquo
Development of internalizing symptoms during adolescence in three countries: the role of temperament and parenting behaviors
2022
AbstractThis longitudinal study examined the unique and joint effects of early adolescent temperament and parenting in predicting the development of adolescent internalizing symptoms in a cross-cultural sample. Participants were 544 early adolescents (T1: Mage = 12.58; 49.5% female) and their mothers (n = 530) from Medellín, Colombia (n = 88), Naples, Italy (n = 90), Rome, Italy (n = 100) and Durham, North Carolina, United States (African Americans n = 92, European Americans n = 97, and Latinx n = 77). Early adolescent negative emotionality (i.e., anger and sadness experience), self-regulation (i.e., effortful control), and parent monitoring and psychological control were measured at T1. Ad…
Variability and Symmetry of Force Platform Variables in Maximum-Speed Running in Young and Older Athletes
2010
Eighteen young (23 ± 4 yr) and 25 older (70 ± 4 yr) male sprinters were examined for ground reaction force (GRF) and temporal-spatial variables. The data were collected during maximum-speed phase, and variability and symmetry indices were calculated from a total of 8 steps. There was little variation (CV < 6%) in vertical and resultant GRF and kinematic variables, while impact loading had high variability (CV: 10–21%). Overall, the pattern of variability was similar in both groups. Yet, a small but significant age-related increase in CV was evident in horizontal GRFs. There was a variable-specific asymmetry between legs but it was not related to leg dominance. No age differences existed …
Absent pedal pulse and impaired balance in older people: a cross-sectional and longitudinal study
2006
Background and aims: The purpose of this study was to determine the relationship between abnormal pedal pulse status and postural balance in older people. Methods: Prospective, population-based cohort study of older residents in the city of Jyvaskyla, Finland. A total of 419 individuals aged 75 or 80 at baseline, with known lower extremity pulse status and balance tests performed on a force platform, were eligible for analysis. Results: Cross-sectionally, persons with both dorsal pedal artery pulses absent were found to sway more (p=0.047 anteroposterior velocity, normal standing eyes-open position). The risk of being unable to do the full tandem stance was twofold (OR=2.20, 95% CI 1.29–3.7…