Search results for "TG"
showing 10 items of 2275 documents
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor
2013
The Eph–ephrin system plays a critical role in tumor growth and vascular functions during carcinogenesis. We had previously identified cholanic acid as a competitive and reversible EphA2 antagonist able to disrupt EphA2-ephrinA1 interaction and to inhibit EphA2 activation in prostate cancer cells. Herein, we report the synthesis and biological evaluation of a set of cholanic acid derivatives obtained by conjugation of its carboxyl group with a panel of naturally occurring amino acids with the aim to improve EphA2 receptor inhibition. Structure-activity relationships indicate that conjugation of cholanic acid with linear amino acids of small size leads to effective EphA2 antagonists whereas …
Evaluating the citywide Edinburgh 20mph speed limit intervention effects on traffic speed and volume: A pre-post observational evaluation.
2021
Objectives Traffic speed is important to public health as it is a major contributory factor to collision risk and casualty severity. 20mph (32km/h) speed limit interventions are an increasingly common approach to address this transport and health challenge, but a more developed evidence base is needed to understand their effects. This study describes the changes in traffic speed and traffic volume in the City of Edinburgh, pre- and 12 months post-implementation of phased city-wide 20mph speed limits from 2016–2018. Methods The City of Edinburgh Council collected speed and volume data across one full week (24 hours a day) pre- and post-20mph speed limits for 66 streets. The pre- and post-sp…
“Living in Contaminated Areas”—Consideration of Different Perspectives
2020
Following large-scale nuclear power plant accidents such as those that occurred at Chernobyl (Ukraine) in 1986 and Fukushima Daiichi (Japan) in 2011, large populations are living in areas containing residual amounts of radioactivity. As a key session of the ConRad conference, experts were invited from different disciplines to provide state-of-the-art information on the topic of "living in contaminated areas." These experts provided their different perspectives on a range of topics including radiation protection principles and dose criteria, environmental measurements and dose estimation, maintaining decent living and working conditions, evidence of health risks, and social impact and risk c…
Differential Effect on the Determinants of the Late Payments According to the Economic Cycle
2018
From 2004 to 2007, the Spanish financial system grew at a very rapid rate. However, from 2008 to 2012 impairment losses amounted equivalent to 25% of Spanish GDP.The objective of this paper is investigate how have affected the main problems that have suffered the Spanish economy on the late payments on Spanish credit institutions. And to check whether the effect of these problems is different on stages of growth with respect to the stages of crisis.The main results, according the test Chow, confirmed that there is a structural break in the model in 2007. Also the increase in unemployment increases the late payments and this increase is greater in the stages of growth compared to the stage…
Odwrócony kredyt hipoteczny jako źródło uposażenia emerytalnego (Reverse mortgage as a source of pension equipment)
2016
Jutekliskās uztveres tematizācija Pētera Handkes stāstā „Senviktuāras kalna mācība”
2015
Bakalaura darbs ir veltīts tēmai „Jutekliskās uztveres tematizācija Pētera Handkes stāstā Senviktuāra kalna mācība”. Darba mērķis ir izmeklēt un aplūkot Pētera Handkes jutekliskās uztveres atspoguļojumu stāstā Senviktuāra kalna mācība. Darba uzdevums ir izpētīt rakstnieka Pētera Handkes personību un viņa slaveno tetraloģiju, it īpaši tetraloģijas otro daļu. Darbs ir sadalīts trijās nodaļās. Pirmajā nodaļā tiek apskatīts un visparēji raksturots jēdziens „mūsdienu literatūra”, kā arī tiek apskatīta tā laika politiskā un sabiedriskā situācija Vācijā un Austrijā. Papildus tiek apskatīta mūsdienu rakstnieku paaudze un Pēters Handke tiek prezentēts kā mūsdienu vācu rakstnieku paaudzes populārs pā…
Programa experimental per al foment de l'ús de llibres de text en dispositius electrònics : estudi d'un cas
2015
L'aparició al mercat de les tauletes digitals ha marcat un abans i un després en l'ensenyament. Aquesta eina tecnològica es perfila com un recurs innovador de cara a la seua utilització educativa. I, com tots sabem, l'escola no pot quedar-se al marge d'aquesta revolució tecnològica. Analitzar l'impacte sobre l'alumnat de l'ús de les tauletes digitals, extraure els seus avantatges i inconvenients i generar idees sobre el seu ús ens pot portar a una educació de qualitat. En aquest article s’analitza la posada en pràctica d’aquest nou projecte anomenat Programa experimental per al foment de l'ús de llibres de text en dispositius electrònics anomenats tauletes digitals en un centre de titularit…
Poesias con que han adornado la fachada de su templo los PP. de la Escuela Pia con el plausible motivo de la venida de SS. MM. y AA. a Valencia.
Sign.: [ ]2, A-M2, N3
Ioan. Bapt. Cardonae ... De regia S. Laurentii bibliotheca ; De Pontificia Vaticana ; De expungendis haereticor. propiis nominib. ; De dyptichis.
1587
Orn.
Poblacion general de España : Sus trofeos, blasones y conquistas heroycas : Descripciones agradables, grandezas notables, excelencias gloriosas y su…
1675
Esc. real xil. a la f. 259 [i. e. 257 Port. a dues tintes Text a dues col. Sign.: ^8, A8, B-Z6, Aa-Vu6, Xx4 Errates tip. a la fol.: de la 258 passa a la 261