Search results for "TG"
showing 10 items of 2275 documents
The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist – from fundamentals to future challenges
2021
The role of the intestine in human health and disease has historically been neglected and was mostly attributed to digestive and absorptive functions. In the past two decades, however, discoveries related to human nutrition and intestinal host-microbe reciprocal interaction have established the essential role of intestinal health in the pathogenesis of chronic diseases and the overall wellbeing. That transfer of gut microbiota could be a means of disease phenotype transfer has revolutionized our understanding of chronic disease pathogenesis. This narrative review highlights the major concepts related to intestinal microbiota, metabolism, and metabolome (3M) that have facilitated our fundame…
From medical data to simple virtual mock-up of scapulo-humeral joint
2008
The surgical operations of shoulder joint are guided by various principles: osteosynthesis in the case of fracture, osteotomy in order to correct a deformation or to modify the functioning of the joint, or implementation of articular prosthesis. At the end of the twentieth century, many innovations in the domains of biomechanics and orthopedic surgery have been performed. Nevertheless, theoretical and practical problems may appear during the operation (visual field of surgeon is very limited, quality and shape of the bone is variable depending on the patient). Biomechanical criteria of success are defined for each intervention. For example, the installation with success of prosthetic implan…
Effect of a Rigid Sulfonamide Bond on Molecular Folding: A Case Study
2015
A disulfonamide compound with bulky aromatic side chains was prepared, and its properties as a potential building block for foldamers were evaluated. Two different solvate crystal forms of the compound were identified and compared to the structures of an analogous oligoamide and related disulfonamides. The disulfonamide is unfolded in one of the solvates, whereas in the other one, a loosely folded conformer stabilized by an intramolecular hydrogen bond is found. Density functional calculations indicated that the loosely folded conformer is slightly more stable than its unfolded isomer. The calculations also identified a third, more tightly folded and more extensively hydrogen bonded, confor…
Proteome adaptations under contrasting soil phosphate regimes of Rhizophagus irregularis engaged in a common mycorrhizal network.
2021
International audience; For many plants, their symbiosis with arbuscular mycorrhizal fungi plays a key role in the acquisition of mineral nutrients such as inorganic phosphate (Pi), in exchange for assimilated carbon. To study gene regulation and function in the symbiotic partners, we and others have used compartmented microcosms in which the extra-radical mycelium (ERM), responsible for mineral nutrient supply for the plants, was separated by fine nylon nets from the associated host roots and could be harvested and analysed in isolation. Here, we used such a model system to perform a quantitative comparative protein profiling of the ERM of Rhizophagus irregularis BEG75, forming a common my…
Atgriezeniskās saites digitāli nodrošināšana attālinātā mācību procesā ķīmijā
2021
Atgriezeniskās saites nodrošināšana attālinātā mācību procesā digitāli. Kārlis Krastiņš, darba vadītāja: Mg. Chem. Ilze Gaile. Bakalaura darbs, 81 lpp, 27 literatūras avoti, 13 attēli, 4 tabulas, 5 pielikumi. Latviešu valodā. Darba mērķis ir izpētīt atgriezeniskās saites nodrošināšanas iespējas ķīmijas mācību stundās attālinātā mācību procesa ietvaros un, noskaidrot atgriezeniskās saites ietekmi uz skolēnu mācību sniegumu uzlabošanu. Literatūras analīze veikta par vērtēšanu, atgriezenisko saiti, IKT rīkiem, kurus iespējams izmantot, sniedzot atgriezenisko saiti skolēnam. Pētījuma empīriskajā daļā ir izveidots un aprobēts tematiskais plāns un stundu plāni, tajos iekļaujot atgriezeniskās sait…
Formatīvā vērtēšana digitāli bioloģijā un ģeogrāfijā
2019
Darba mērķis ir izpētīt formatīvās vērtēšanas (FV) digitāli izmantošanu bioloģijas un ģeogrāfijas mācību procesā. Literatūras analīze veikta par vērtēšanu, atgriezenisko saiti, IKT rīkiem un FV digitālajiem rīkiem bioloģijā, ģeogrāfijā. Empīriskajā daļā analizēti un aprobēti trīs FV digitālie rīki bioloģijā, ģeogrāfijā, izvērtēta skolotāju, skolēnu, vecāku attieksme digitālo rīku lietošanā. Pētījuma rezultāti pierāda, ka izmantotie FV digitālie rīki nodrošina jēgpilnu FV un kvalitatīvu atgriezenisko saiti bioloģijā un ģeogrāfijā.
National identity predicts public health support during a global pandemic
2022
Funder: Research Council of Norway through its Centres of Excellence Scheme, FAIR project No 262675
Lessons from the 2018-2019 European droughts : a collective need for unifying drought risk management
2022
Funding Information: This open-access publication was funded by the University of Freiburg. Funding Information: Financial support. The project is supported by the Wassernetzwerk Baden-Württemberg (Water Research Network of the State Baden-Württemberg), which is funded by the Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg (Ministry of Science, Research and the Arts of the State Baden-Württemberg) (grant no. AZ. 7532.21/2.1.6) and Maa-ja vesitekniikan tuki ry foundation. Doris E. Wendt acknowledges her support as part of the NERC-funded Groundwater Drought Initiative (NE/R004994/1). Lucy J. Barker was supported by the Natural Environment Research Council (NE/R016429/1) a…
Literacy skills seem to fuel literacy enjoyment, rather than vice versa
2023
Children who like to read and write tend to be better at it. This association is typically interpreted as enjoyment impacting engagement in literacy activities, which boosts literacy skills. We fitted direction-of-causation models to partial data of 3690 Finnish twins aged 12. Literacy skills were rated by the twins' teachers and literacy enjoyment by the twins themselves. A bivariate twin model showed substantial genetic influences on literacy skills (70%) and literacy enjoyment (35%). In both skills and enjoyment, shared-environmental influences explained about 20% in each. The best-fitting direction-of-causation model showed that skills impacted enjoyment, while the influence in the othe…
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
2015
Contains fulltext : 155360.pdf (Publisher’s version ) (Closed access) Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and b…