Search results for "THERAPY"
showing 10 items of 12482 documents
Factors Affecting Digital Tool Use in Client Interaction According to Mental Health Professionals : Interview Study
2023
Background: Digital tools and interventions are being increasingly developed in response to the growing mental health crisis, and mental health professionals (MHPs) considerably influence their adoption in client practice. However, how MHPs use digital tools in client interaction is yet to be sufficiently understood, which poses challenges to their design, development, and implementation. Objective: This study aimed to create a contextual understanding of how MHPs use different digital tools in clinical client practice and what characterizes the use across tools. Methods: A total of 19 Finnish MHPs participated in semistructured interviews, and the data were transcribed, coded, and inductiv…
Gender differences in usage and user experience of Oiva App
2015
Previous research has indicated that gender is an important demographic to consider when designing effective and tailored technology interventions. Despite this need, gender differences is still an understudied topic in the field of technology interventions. The objective of this study was to study gender differences in usage and user experience of a mental wellness app called Oiva. Gender differences in the app’s effect on the participants’ mental well-being were also investigated. Oiva is a stand-alone mental wellness app that aims to increase its users’ psychological flexibility by teaching Acceptance and Commitment Therapy (ACT) based skills. The study population of the current study wa…
The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.
2021
Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indications. In order to ensure clinical efficacy and safety aspects, (pre-)clinical experimental approaches evaluate the respective modes of action (MoA). In addition to antigen-specificity including binding affinity and -avidity, MoA comprise Fc-mediated effector functions such as antibody dependent cellular cytotoxicity (ADCC) and the closely related antibody dependent cellular phagocytosis (ADCP). For this reason, a variety of cell-based assays have…
Identity development meets emotional stability : transcending borders through music therapy with an intercultural group of women : a case study
2016
Based on previous investigation, research has revealed the implications of music therapy in women, intercultural groups, and the cultivation of identity and emotional stability. However, the research conducted on the amalgamation of these factors is deficient. The purpose of this case study is to explore the effects of music therapy on the emotional stabilization and development of identity in an intercultural group of women. The umbrella terms of identity development and emotional stability will be dissected based on the sub-themes that have emerged from the therapeutic needs of the intercultural group of individuals involved. Six women from The Netherlands, Iran, China, Russia, Germany, a…
Exploring the practical framework of a multicultural music therapy group for children with emotional and behavioral needs in an after-school setting
2016
Research shows that music therapy is effective in addressing therapeutic goals for groups of children with emotional and behavioral needs. However, most of the current research focuses on behavioral approaches to music therapy with children, and lacks in-depth explanations of practical frameworks surrounding the process (i.e., organizing, planning and implementing a group) for non-directive children’s music therapy groups focused on emotional and behavioral needs in the school setting. The following case study explores the practical framework surrounding a multicultural music therapy group for children with emotional and behavioral needs at an elementary school in Jyväskylä, Finland. The ma…
The relationships among motivational climate, perceived competence, physical performance, and affects during physical education fitness testing lesso…
2021
Despite the prominence of fitness testing in school physical education (PE), there is a sparsity of research examining the antecedents of students’ affective experiences during fitness testing lessons. This study aimed to investigate the associations among task- and ego-involving motivational climates, perceived physical competence, physical performance, enjoyment, and anxiety during two different types of PE fitness testing lessons. Altogether, 645 Finnish students from Grade 5 (50% boys, Mage = 11.2, SD = 0.36) and Grade 8 (47% boys, Mage = 14.2, SD = 0.35) participated in two fitness testing lessons with different content (lesson 1: 20-meter shuttle run test and a test of flexibility; l…
Training practices of Filipino athletes during the early covid-19 lockdown
2022
The imposition of COVID-19 lockdown restricted the daily activities of many people, including athletes. This study investigated the training practices of athletes in the Philippines during the first COVID-19 lockdown. A total of 442 athletes answered an online survey (May-July 2020), with questions pertaining to training practices, such as training frequency and duration. Data were analyzed according to: athlete classification (world-class, international, national, state, or recreational), sport category (individual or team), and sex (male or female). During lockdown, significant reductions in training frequency (except recreational, i.e., lower pre-lockdown training) and duration were obse…
Bicarbonate sodium oral-rinse in patients with oral mucositis induced by chemotherapy and radiotherapy: does it give a real chance for management?
2020
Rational Chemical Multifunctionalization of Graphene Interface Enhances Targeted Cancer Therapy
2020
The synthesis of a drug delivery platform based on graphene was achieved through a step‐by‐step strategy of selective amine deprotection and functionalization. The multifunctional graphene platform, functionalized with indocyanine green, folic acid, and doxorubicin showed an enhanced anticancer activity. The remarkable targeting capacity for cancer cells in combination with the synergistic effect of drug release and photothermal properties prove the great advantage of a combined chemo‐ and phototherapy based on graphene against cancer, opening the doors to future therapeutic applications of this type of material.
Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
2023
AbstractThe historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. Fifteen genetically diverse models developed bone marrow (BM) tumors fulfilling MM pathogenesis. Integrative analyses of ∼500 mice and ∼1,000 patients revealed a common MAPK–MYC genetic pathway that accelerated time to progression from precursor states across genetically heterogeneous MM. MYC-dependent time …