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RESEARCH PRODUCT
Rational Chemical Multifunctionalization of Graphene Interface Enhances Targeted Cancer Therapy
Gonzalo AbellánEijiro MiyakoGiacomo ReinaAlberto BiancoYue YuYue YuMatteo Andrea Lucherellisubject
multifunctionalizationCarbon materialsCancer therapyAntineoplastic AgentsNanotechnology[CHIM.THER]Chemical Sciences/Medicinal Chemistry010402 general chemistry01 natural sciencesCatalysislaw.inventionDrug Delivery SystemslawCell Line TumorNeoplasmsmedicineHumanscancerDoxorubicindiazonium saltsCàncerMaterialsComputingMilieux_MISCELLANEOUSgraphite010405 organic chemistryGrapheneChemistryCancerGeneral MedicineGeneral ChemistryPhotothermal therapymedicine.disease0104 chemical sciencesDrug deliveryCancer cellSurface modificationmedicine.drugdescription
The synthesis of a drug delivery platform based on graphene was achieved through a step‐by‐step strategy of selective amine deprotection and functionalization. The multifunctional graphene platform, functionalized with indocyanine green, folic acid, and doxorubicin showed an enhanced anticancer activity. The remarkable targeting capacity for cancer cells in combination with the synergistic effect of drug release and photothermal properties prove the great advantage of a combined chemo‐ and phototherapy based on graphene against cancer, opening the doors to future therapeutic applications of this type of material.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-08-10 | Angewandte Chemie International Edition |