Search results for "TLA"
showing 10 items of 1764 documents
Characterization of Human γδ T Lymphocytes Infiltrating Primary Malignant Melanomas
2012
T lymphocytes are often induced naturally in melanoma patients and infiltrate tumors. Given that gamma delta T cells mediate antigen-specific killing of tumor cells, we studied the representation and the in vitro cytokine production and cytotoxic activity of tumor infiltrating gamma delta T cells from 74 patients with primary melanoma. We found that gamma delta T cells represent the major lymphocyte population infiltrating melanoma, and both V delta 1(+) and V delta 2(+) cells are involved. The majority of melanoma-infiltrating gamma delta cells showed effector memory and terminally-differentiated phenotypes and, accordingly, polyclonal gamma delta T cell lines obtained from tumor-infiltrat…
Nothodissotis (Melastomataceae), a new genus from Atlantic Central Africa, including the new species N. alenensis from Equatorial Guinea
2019
Based on morphological and phylogenetic evidence, a new genus of Melastomataceae (Melastomateae), Nothodissotis Veranso-Libalah & G.Kadereit, gen. nov., is described from Atlantic Central Africa. Nothodissotis is distinguished from other African Melastomateae genera by its calyx-lobes that are notched at apex and asymmetrical (vs. entire and symmetrical). Nothodissotis includes two species: the type species N.barteri (Hook.f.) Veranso-Libalah & G.Kadereit, comb. nov. (syn. Dissotisbarteri Hook.f.), and the new species N.alenensis Veranso-Libalah & O. Lachenaud, sp. nov., described and illustrated here. Both species are restricted to open vegetation on rock outcrops w…
Recent expansion of Northeast Atlantic and Mediterranean populations of Melicertus (Penaeus) kerathurus (Crustacea: Decapoda).
2009
We analysed the genetic diversity of Melicertus kerathurus (Penaeidae), a commercially valuable penaeid shrimp that is distributed in the Mediterranean Sea and eastern Atlantic Ocean. We examined the polymorphism of a 494 bp DNA segment of the mitochondrial COI region in 173 individuals, sampled in nine Mediterranean and two Atlantic samples, covering the whole range of the species from the tropical waters of the Gulf of Guinea to the eastern part of the Mediterranean Sea. The mean nucleotide and haplotype diversities were π = 0.00275 and h = 0.718, respectively, for the global data set, with the highest values occurring in the African samples and the lowest in the Adriatic Sea. A clear sam…
T-bet as a possible therapeutic target in autoimmune disease
2002
The prominent role of pro-inflammatory cytokines produced by T helper-1 (T(H1)) cells in regulating autoimmune responses in vitro and in vivo has been demonstrated. Recent observations of T cell polarisation by regulatory transcription factors--especially T-bet (T-box expressed in T cells)--raise the question of their influence in controlling autoimmune diseases. Here, the authors summarise recent observations of the role of T-bet in controlling chronic inflammatory and autoimmune diseases and discuss the implications of these findings for future therapeutic approaches.
Using Matlab's wavelet toolbox to compare electric signals outputted by microbial fuel cells
2019
Motivation: microbial fuel cells (MFC) represents a wastewater treatment technology with the potential for a relevant electric energy generation. The monitoring of the electric current outputted generates time series of data. It was generated two time series using an experimental setup with a low-cost dual chamber microbial fuel cell treating cassava wastewater and, also, it was used the electric current data from a previously described experiment with this same setup treating cheese whey. All of this, innovatively, according our best knowledge, was studied using power spectral density, multifractal and wavelet coherence analysis. Results are promising and indeed point out this approach as …
Epidemiology and molecular investigation of hepatitis C infection following holiday haemodialysis
2012
Background: Hepatitis C virus infection (HCV) is not infrequent among haemodialysis patients. Most published reports suggest that patient-to-patient spread, either directly or indirectly, is the most common mode of transmission in renal units. Aim: To investigate the source of an outbreak, and the route of transmission, of acute HCV infection in two Scottish patients occurring within eight weeks of receiving haemodialysis in the same unit while on holiday in Majorca. Methods: This was an international epidemiological and molecular investigation of HCV infection among a cohort of haemodialysis patients from nine countries. Findings: No further HCV-positive infections were observed among resi…
A molecular method to assess Phytophthora diversity in environmental samples
2012
Current molecular detection methods for the genus Phytophthora are specific to a few key species rather than the whole genus and this is a recognized weakness of protocols for ecological studies and international plant health legislation. In the present study a molecular approach was developed to detect Phytophthora species in soil and water samples using novel sets of genus-specific primers designed against the internal transcribed spacer (ITS) regions. Two different rDNA primer sets were tested: one assay amplified a long product including the ITS1, 5.8S and ITS2 regions (LP) and the other a shorter product including the ITS1 only (SP). Both assays specifically amplified products from Phy…
High Prevalence of Human-Associated Escherichia coli in Wetlands Located in Eastern France
2020
International audience; Escherichia coli that are present in the rivers are mostly brought by human and animal feces. Contamination occurs mostly through wastewater treatment plant (WWTP) outflows and field amendment with sewage sludge or manure. However, the survival of these isolates in river-associated wetlands remains unknown. Here, we assessed E. coli population structure in low-anthropized wetlands located along three floodplains to identify the major source of contamination of wetlands, whose functioning is different from the rivers. We retrieved 179 E. coli in water samples collected monthly from 19 sites located in eastern France over 1 year. Phylogroups B1 and B2 were dominant in …
Difficulties in distinguishing between an atlas fracture and a congenital posterior atlas arch defect in postmortem analysis.
2013
We found one atlas from a sample of 148 skeletons (0.67%) that presented different anatomical variations which made it difficult to determine whether the vertebra had an atlas fracture, an unusual Type B posterior atlas arch defect, or a combination of both. We carried out a stereomicroscopy, radiographic, and computerized tomography scan study that revealed that the dry atlas we found presented a very uncommon congenital Type B posterior atlas arch defect, simulating a fracture. In short, the present paper has revealed that differentiating Type B posterior atlas arch defects from fractures in post-mortem dry vertebrae is more difficult than expected. Thus we believe that it can be easier t…
Assessment of the interaction of Portland cement-based materials with blood and tissue fluids using an animal model
2016
Portland cement used in the construction industry improves its properties when wet. Since most dental materials are used in a moist environment, Portland cement has been developed for use in dentistry. The first generation material is mineral trioxide aggregate (MTA), used in surgical procedures, thus in contact with blood. The aim of this study was to compare the setting of MTA in vitro and in vivo in contact with blood by subcutaneous implantation in rats. The tissue reaction to the material was also investigated. ProRoot MTA (Dentsply) was implanted in the subcutaneous tissues of Sprague-Dawley rats in opposite flanks and left in situ for 3 months. Furthermore the material was also store…