Search results for "TLE"
showing 10 items of 2417 documents
l-Glutamate receptor binding in bovine retina
1982
Using a centrifugation technique saturable specific [ 3 H]glutamate binding in bovine retina could be demonstrated. Scatchard analysis revealed only one population of binding sites with a dissociation constant of about 3 μ m and a maximal number of binding sites of about 0·2 pmol/mg retinal protein. Several glutamic acid analogues inhibit specific [ 3 H]glutamate binding in bovine retina with half-maximal inhibitory concentrations similar to those reported in other areas of the CNS. Specific [ 3 H]glutamate binding and sodium dependent synaptosomal uptake of glutamate are largely concentrated in the P2 fraction of bovine retina homogenates consisting of conventionally sized synaptosomes. Th…
Pore formation by Vibrio cholerae cytolysin requires cholesterol in both monolayers of the target membrane
2007
Vibrio cholerae cytolysin (VCC) forms oligomeric transmembrane pores in cholesterol-rich membranes. To better understand this process, we used planar bilayer membranes. In symmetric membranes, the rate of the channel formation by VCC has a superlinear dependency on the cholesterol membrane fraction. Thus, more than one cholesterol molecule can facilitate VCC-pore formation. In asymmetric membranes, the rate of pore formation is limited by the leaflet with the lower cholesterol content. Methyl-beta-cyclodextrin, which removes cholesterol from membranes, rapidly inhibits VCC pore formation, even when it is added to the side opposite that of VCC addition. The results suggest that cholesterol i…
Quasi-brittle porous material: Simulated effect of stochastic air void structure on compressive strength
2021
Abstract The effect of porosity comprised of spherical air voids on the compressive strength of quasi-brittle material was studied via simulations. The simulated porous structures were based on pore size distributions of two mortar samples measured by X-ray microtomography. While the simulation method set practical limits on the size of sample, the base of the statistics was established by simulating 128 small structures generated by sampling from pore structures of two mortars. By studying the application of the classical strength-porosity formulas to the simulated data, a new simple model was formed. A linear relationship was achieved between the cubic root of air void fraction (porosity)…
Rīcībspējas trūkums dzimtes un subjekta attiecībās Džūditas Batleres filozofijā: posthumānisma fenomenoloģijas feminisma risinājums
2022
Džūditai Batlerei, poststrukturālisma un feminisma filozofei, dzimte un patība, kas ir savstarpēji nenošķirami, veidojas un pastāv sociālajā kontekstā un varas laukā, būdami diskursa ietekmēti. Filozofe piedāvā, ka cilvēkam nav pirmsdiskursīva kodola un ka piekļuve identitātei, kā arī sevis izziņa ir iespējama tikai ar konvenciju un normu starpniecību. Šāda nostāja rada rīcībspējas jeb spējas pašnoteikties trūkumu un cilvēka subjektīvās pieredzes ignorēšanu attiecībā uz dzimti un patību. Darba mērķis ir risināt rīcībspējas problēmu ar feministisko posthumānisma fenomenoloģijas pieeju, piedāvājot, ka Džūditas Batleres teorija var tikt pilnveidota ar iemiesotības un dzīvotās pieredzes koncept…
Titulature et pouvoir de l’empereur Trajan dans les provinces de l’Occident romain d’après l’épigraphie et la statuaire
2018
Through the analysis of the epigraphic and statuary evidence that relates to emperor Trajan in the cities of the western provinces, my objective is to determine the various forms of expression of allegiance and loyalty of the provincials towards him . The presence of Trajan through these two forms of expression usually privileged for imperial propaganda is very significant. It is due to several factors: Trajan is originally from Italica, in Betic, He is the first provincial to take power in Rome; then he is called Best of Princes; and he was a great soldier and a good administrator during a long reign of 19 years and a half. He was therefore honored by many epigraphic documents erected on t…
Crustal age domains in the Kibaran belt of SW-Uganda: Combined zircon geochronology and Sm–Nd isotopic investigation
2008
Abstract Combination of geochemistry, Nd mean crustal residence ages and single zircon ages reveal distinct provinces not recognized previously within the Kibaran belt of SW-Uganda. Geochemical analyses (HFSE and REE) of four granitoids, namely the Ntungamo, Chitwe, Rwentobo and Kamwezi from the Karagwe Tinfield have been interpreted to be mainly composed of melt components from subduction modified parts of the continental lithospheric mantle. In addition we can demonstrate, from these distinctive batholiths crystallization ages that lead to the result of three age groups, one at around 1566 Ma, the second at 1444 Ma to and the third clusters between 1329 Ma and 1363 Ma. The eNd(t) values f…
Oral health knowledge in pre-school children: a survey among parents in central Italy
2019
Background The aim of this survey was to evaluate the knowledge and awareness of parents about potential oral health risk factors and correct management of oral hygiene of their preschool children. Material and Methods The participation to the survey was proposed to all parents of 3-5 year aged children attending a kindergarten in Campobasso. A self-administered questionnaire was completed to obtain information regarding demographic and education variables, knowledge about caries and its transmission, infant feeding practice, maternal oral health during pregnancy, parents and children's oral hygiene habits and risk behaviors (e.g., sharing cutlery, tasting of baby food, nightly using of bab…
Characterization of trophic links in an agrosystem : weed seed predation by carabid beetles
2012
Agroecology gives evidence of new perspectives in agriculture, and open doors for alternative weed management approaches through different regulation mechanisms. Seed predation is one of them, and the interest is growing to deepen knowledge, relative to this process. This Phd work aims (i) to describe weed seed predation, the dominant carabid predators and the available resource at a local scale in a common crop (winter wheat); (ii) to study predation profiles of main predators, and the pair-wise correlations between the biological components of the system; (iii) to bring new insights regarding potential regulation of weed communities, through seed predation by carabid beetles. Complementar…
Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo.
2009
Abstract Both the cellular prion protein (PrPc) and the amyloid precursor protein (APP) are physiologically subjected to complex proteolytic processing events. While for APP the proteinases involved – alpha-, beta- and gamma-secretase – have been identified in vitro and in vivo, the cleavage of PrPc by now has been linked only to the shedding activity of the metalloproteinase ADAM10 and/or ADAM17 in cell culture. Here we show that neuronal overexpression of the alpha-secretase ADAM10 in mice reduces all PrPc species detected in the brain instead of leading to enhanced amounts of specific cleavage products of PrPc. Additionally, the incubation time of mice after scrapie infection is signific…
A Prioritisation Model Aiding for the Solution of Illegal Buildings Problem
2016
In Italia, in particolare nelle aree del Sud, la costruzione di edifici e insediamenti abusivi è un problema importante e annoso che rimane irrisolto a dispetto di tre condoni edilizi. Ne deriva che le autorità pubbliche si trovano ad affrontare il problema della demolizione di un ingente numero di edifici, come prescritto dalla legislazione in materia. Ragioni di natura sociale e finanziaria impongono tuttavia l’esecuzione degli ordini di demolizione in maniera poco concentrata nel tempo, evidenziando il problema decisionale di stabilire un ordine di priorità relativo agli edifici interessati. Questa situazione preoccupante è divenuta oggetto di uno specifico disegno di legge che propone e…