Search results for "TLE"
showing 10 items of 2417 documents
New combinations for mantle cell lymphoma: concerted action needed.
2011
The influence of Span®20 on stratum corneum lipids in Langmuir monolayers: comparison with Azone®
2000
Recently we have proved that Span 20 has the same enhancer effect as Azone on in vitro percutaneous penetration of lipophilic compounds (logP(oct) from 1.34 to 2.33). The purpose of this work is to study the interactions of Span 20 with stratum corneum lipids monolayers and to compare them with Azone. The surface pressure-area characteristics of Span 20 in mixed monolayers with different model lipids (ceramides, cholesterol, free fatty acids and two mixtures of ceramides+cholesterol, and ceramides+cholesterol+free fatty acids) in similar proportions to that which exists in human stratum corneum lipids were recorded as compression isotherms at 25 degrees C. Azone was also investigated on mon…
The role of slabs and oceanic plate geometry in the net rotation of the lithosphere, trench motions, and slab return flow
2012
[1] Absolute plate motion models with respect to a deep mantle reference frame (e.g., hot spots) typically contain some net rotation (NR) of the lithosphere. Global mantle flow models for the present-day plate setting reproduce similarly oriented NRs but with amplitudes significantly smaller than those found in some high NR Pacific hot spot reference frames. It is therefore important to understand the mechanisms of NR excitation, which we attempt here with two-dimensional cylindrical models of an idealized Pacific domain. We study the influence of slab properties, oceanic ridge position, continental keels, and a weak asthenospheric layer on NR and trench migration. Fast slab return flow dev…
Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders
2019
Insomnia, vasomotor symptoms (VMS) and depression often co-occur after the menopause, with consequent health problems and reductions in quality of life. The aim of this position statement is to provide evidence-based advice on the management of postmenopausal sleep disorders derived from a systematic review of the literature. The latter yielded results on VMS, insomnia, circadian rhythm disorders, obstructive sleep apnea (OSA) and restless leg syndrome (RLS). Overall, the studies show that menopausal hormone therapy (MHT) improves VMS, insomnia, and mood. Several antidepressants can improve insomnia, either on their own or in association with MHT; these include selective serotonin reuptake …
Sleep disorders in menopause: Results from an Italian multicentric study
2016
Menopause in the female life cycle is a special period due to important hormonal, physical and psychological changes. Sleep disruption represents a common complaint for midlife and menopausal women, related to primary sleep disorders, including insomnia, sleep disordered breathing, restless legs syndrome (RLS), mood and anxiety disorder, other medical illness, hormonal-related vasomotor symptoms, and aging per se. Aims of our study were to evaluate the prevalence of sleep disorders in a sample of pre and post menopausal women, and to investigate the relationship between sleep and other medical disorders, and life habits. Among workers in the six participant centers, we enrolled 334 women, a…
REM sleep behavior disorder and periodic leg movements in sleep in patients with amyotrophic lateral sclerosis
2013
Introduction In the last few years, it has been increasingly recognized that patients with amyotrophic lateral sclerosis (ALS) frequently suffer of sleep-related complaints, including insomnia, restless legs syndrome, and daytime sleepiness, although, in the past, many of the nocturnal symptoms have been mainly ascribed to chronic respiratory insufficiency and hypoventilation. In addition, excluding few single cases reported, polysomnographic studies did not look for abnormal motor activity during sleep that could be indicative of Rapid Eye Movements (REM) sleep behavior disorder (RBD) and REM sleep without atonia (RSWA), which are highly prevalent in other neurodegenerative disorders with …
Restless legs syndrome in patients with amyotrophic lateral sclerosis
2010
We aimed to evaluate the frequency and determinants of restless legs syndrome (RLS) in a group of 76 patients with amyotrophic lateral sclerosis (ALS) and 100 control subjects. A diagnosis of RLS was made according to the criteria of the International RLS Study Group, and severity was assessed by the RLS severity scale. RLS was significantly more frequent in patients with ALS (ALS/RLS(+)) than in control subjects (25% vs. 8%; P = 0.002). Compared with control subjects, patients with ALS/RLS(+) showed shorter history of RLS complaints and higher frequency of symptoms occurrence. Moreover, compared with those without RLS, patients with ALS/RLS(+) showed increased functional impairment and mor…
Qualification d’investissement et compétence en arbitrage international relatif aux investissements : la théorie du contrôle séparé devant le CIRDI
2014
La compétence d’un arbitre chargé d’appliquer le droit international des investissements exige l’existence préalable d’un investissement étranger. La présente étude analyse les difficultés du contrôle de l’existence de l’investissement devant le Centre international pour le règlement des différends relatifs aux investissements (CIRDI) et propose des moyens pour les surmonter. L’importance de la Convention de Washington du 18 mars 1965 explique l’attention particulière portée au CIRDI. En tenant compte des diverses approches proposées par la doctrine et la jurisprudence et de leurs fondements, la démarche suggérée par l’auteur est basée sur la dissociation des sources conventionnelles à l’or…
‘Whose side are you on?’: negotiations between individual liberty and collective responsibility in Millar and McNiven’sMarvel Civil War
2015
The Civil War series by Mark Millar and Steve McNiven, published between July 2006 and January 2007, involves superheroes in a battle among themselves as an allegory for political conflicts of the United States, post-Patriot Act. Akin to Alan Moore’s Watchmen and the Uncanny X-Men series, Civil War centers on a political solution to regulate and control superhero vigilante justice. The rhetoric represented by the conflicting factions orbits the concerns of individual liberty vs. collective responsibility, with Captain America (a World War Two and Cold War warrior) siding most adamantly against government supervision and Iron Man fighting in favor of government control. The civil war played …