Search results for "TLE"

Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells

2004

The objective of our study was to determine the regulatory effects that endogenous transforming growth factor beta (TGFbeta) exerts on T cells in the pathogenesis of collagen-induced arthritis (CIA). CIA was induced in transgenic mice expressing a dominant negative TGFbeta type II receptor in T cells under the control of the human CD2 promoter. Clinical and histological arthritis scores were determined and experiments on disease induction and the healing phase of disease were performed. The proliferation and cytokine production of draining lymph node cells in vitro were analyzed. Transgenic mice were more susceptible to induction of CIA. The overall incidence was higher in transgenic mice t…

Late Cenozoic brittle deformation in the Southern Patagonian Andes: Record of plate coupling/decoupling during variable subduction?

2018

The Andes of southern Patagonia experienced a Miocene shift towards faster and higher angle subduction followed by the approach and collision of the Chile oceanic ridge. We present a kinematic study characterizing palaeostress fields computed from brittle tectonics to better constrain upper crustal deformation during this complex scenario. Although previous studies already suggested variable kinematics, it is striking that in a long-lasting subduction environment, the computed palaeostress tensors are mostly strike-slip (55%), while 35% are extensional, and only 10% compressive which are concentrated along a main frontal thrust. Cross-cutting relationships and synsedimentary deformation ind…

A 5500-year oxygen isotope record of high arctic environmental change from southern Spitsbergen

2017

The oxygen isotope composition of chironomid head capsules in a sediment core spanning the past 5500 years from Lake Svartvatnet in southern Spitsbergen was used to reconstruct the oxygen isotope composition of lake water (δ18Olw) and local precipitation. The δ18Olw values display shifts from the baseline variability consistent with the timing of recognized historical climatic episodes, such as the Roman Warm Period, the Dark Ages Cold Period and the ‘Little Ice Age’. The highest values of the record, ca. 3‰ above modern δ18Olw values, occur at ca. 1900–1800 cal. yr BP. Three negative excursions increasing in intensity toward the present, at 3400–3200, 1250–1100, and 350–50 cal. yr BP, are…

Addition of pasture plant essential oil in milk: Influence on chemical and sensory properties of milk and cheese

2007

The aim of this experiment was to study the effect of the addition, to milk, of an essential oil (EO) obtained from the hydrodistillation of plants collected from a mountain natural pasture on the milk and cheese sensory properties. The EO was mainly composed of terpenoid compounds (67 of the 95 compounds identified) as well as ketones, aldehydes, alcohols, esters, alkanes, and benzenic compounds. In milk, the addition of this EO at the concentration of 0.1 microL/L did not influence its sensory properties, whereas at 1.0 microL/L, sensory properties were modified. In cheeses, the effect of adding EO into milk was studied in an experimental dairy plant allowing the production of small Canta…

Observation of intrinsically bright terrestrial gamma ray flashes from the Mediterranean basin

2015

Abstract  We present three terrestrial gamma ray flashes (TGFs) observed over the Mediterranean basin by the Reuven Ramaty High Energy Solar Spectroscope Imager (RHESSI) satellite. Since the occurrence of these events in the Mediterranean region is quite rare, the characterization of the events was optimized by combining different approaches in order to better define the cloud of origin. The TGFs on 7 November 2004 and 16 October 2006 came from clouds with cloud top higher than 10–12 km where often a strong penetration into the stratosphere is found. This kind of cloud is usually associated with heavy precipitation and intense lightning activity. Nevertheless, the analysis of the cloud type…

A Guide to Designing a Memory fMRI Paradigm for Pre-surgical Evaluation in Temporal Lobe Epilepsy

2020

There has been increasing interest in the clinical and experimental use of memory functional Magnetic Resonance Imaging (fMRI). The 2017 American Academy of Neurology practice guidelines on the use of pre-surgical cognitive fMRI suggests that verbal memory fMRI could be used to lateralize memory functions in people with Temporal Lobe Epilepsy (TLE) and should be used to predict post-operative verbal memory outcome. There are however technical and methodological considerations, to optimize both the sensitivity and specificity of this imaging modality. Below we discuss these constraints and suggest recommendations to consider when designing a memory fMRI paradigm.

Differential mode of inhibition of terminal deoxynucleotidyl transferase by 3′-dATP, ATP, βaraATP and αaraATP

1978

Seven Shades of Grey: A Follow-Up Study on the Molecular Basis of Coat Colour in Indicine Grey Cattle Using Genome-Wide SNP Data

2022

Shades of grey and brown are a dominant component in mammal coat colours, representing a fundamental trait involved in a great number of processes including cryptism, sexual selection and signalling. The genetic mechanisms of the grey colouration in mammals are very complex and controlled by hundreds of genes whose effects and interactions are still largely unclear. In this study, we adopted a robust multi-cohort Fst outlier approach based on pairwise contrasts between seven grey indicine cattle breeds and both taurine and indicine non-grey cattle breeds in order to find genomic regions potentially related to the grey colouration. On the basis of three main drawn settings, built in order to…

Geochemistry, PbPb single zircon ages and NdSr isotope composition of Precambrian rocks from southern and eastern Ethiopia: implications for crusta…

1998

Abstract Geochemical and isotope data for granitoid rocks from southern and eastern Ethiopia delineate the presumed margin of the Pan-African juvenile terrain of the Arabian-Nubian Shield against an older crustal segment of unknown origin extending from eastern Ethiopia to northern Somalia. Granitoids from southern Ethiopia have higher Na2O and Na 2 0 K 2 O and lower Cr and Ni than granitoids with comparable SiO2 values from eastern Ethiopia. In southern Ethiopia three periods of magmatism are identified on the basis on single zircon 207 Pb 206 Pb evaporation ages, namely at ∼850, ∼750-700 and ∼650-550 Ma, and these correlate well with events documented from other parts of Ethiopia and the …

Layered lower crust and mantle reflectivity as imaged by a re-processed crustal seismic profile from Sicily in the central Mediterranean

2015

Abstract Though Sicily is a key area for understanding the central Mediterranean tectonics, a number of questions on its dynamics remains open due to the lack of detailed data on the lithospheric structure. Deep reflectivity images of the African lithosphere, beneath Sicily, have been derived from the re-processing of the crustal seismic reflection stack (SI.RI.PRO. Project). Of specific interest was the imaging, beneath central-southern Sicily, of a thinned crust with a reflective, “layered” pattern for the lower crust that differs from the one, thicker and sub-transparent, of the northern-central sector. Brittle deformation in the upper crystalline crust along a low-angle normal fault and…