Search results for "TMS"
showing 10 items of 196 documents
Promoter methylation status of ASC/TMS1/PYCARD is associated with decreased overall survival and TNM status in patients with early stage non-small ce…
2019
Background: Lung cancer is the leading cause of cancer-related death worldwide, with 5-year overall survival less than 15%. Therefore, it is essential to find biomarkers for early detection and prognosis. Aberrant DNA methylation is a common feature of human cancers and its utility is already recognized in cancer management. The aim of this study was to explore the diagnostic and prognostic value of the promoter methylation status of the ASC/TMS1/PYCARD and MyD88 genes, key adaptor molecules in the activation of the innate immune response and apoptosis pathways. Methods: A total of 50 non-small cell lung cancer (NSCLC) patients were enrolled in the study. Methylation of bisulphite converted…
Non-invasive Brain Stimulation in Pediatric Migraine: A Perspective From Evidence in Adult Migraine
2019
Pediatric migraine remains still a challenge for the headache specialists as concerns both diagnostic and therapeutic aspects. The less ability of children to describe the exact features of their migraines and the lack of reliable biomarker for migraine contribute to complicate the diagnostic process. Therefore, there's need for new effective tools for supporting diagnostic and therapeutic approach in children with migraine. Recently, promising results have been obtained in adult headache by means of application of neurostimulation techniques both for investigating pathophysiological mechanisms and also for therapeutical applications. Non-invasive brain stimulation (NIBS) techniques like tr…
GABA—from Inhibition to Cognition:Emerging Concepts
2018
Neural functioning and plasticity can be studied on different levels of organization and complexity ranging from the molecular and synaptic level to neural circuitry of whole brain networks. Across neuroscience different methods are being applied to better understand the role of various neurotransmitter systems in the evolution of perception and cognition. GABA is the main inhibitory neurotransmitter in the adult mammalian brain and, depending on the brain region, up to 25% of the total number of cortical neurons are GABAergic interneurons. At the one end of the spectrum, GABAergic neurons have been accurately described with regard to cell morphological, molecular, and electrophysiological…
Perkusīvie instrumenti 5-6 gadīgu bērnu ritma izjūtas attīstīšanai pirmsskolā
2020
Danas Ščerbinas kvalifikācijas darba tēma ir „Perkusīvie instrumenti 5-6 gadīgu bērnu ritma izjūtas attīstīšanai pirmsskolā”. Tajā aplūkota aktuāla problēma – perkusīvo instrumentu nepietiekama izmantošana pirmsskolas izglītības iestādēs, kā arī nepietiekamais ritma izjūtas attīstības līmenis minētajā vecumposmā – 5-6 gadi. Darbā tika veikta teorētiskas literatūras analīze par ritma izjūtu, par perkusīviem instrumentiem, par perkusīvo instrumentu izmantošanas iespējām pirmsskolas izglītības iestādē un tika sniegts 5-6 gadīgo bērnu raksturojums. Kvalifikācijas darbā galvenais ritma izjūtas attīstīšanas palīglīdzeklis– perkusīvie instrumenti. Literatūras analīzes mērķis ir izpētīt, kā perkusī…
Ancova metode ar pielietojumu biostatistikā
2019
Šajā darbā tiks apskatīta mūsdienās lielu nozīmi ieguvusī ANCOVA metode, kuru izmanto medicīniskos pētījumos. Īss ieskats tiek aplūkots divām metodēm-ANOVA metodei un lineārajai regresijai,lai saprastu kā ANCOVA metode tika izveidota. Tas ir ļoti nozīmīgi, jo tās veido ANCOVA metodi. Kā arī teorijas beigās apskata ANCOVA metodi. Metodi pielietojot jāpārbauda dažādi nosacījumi, tāpēc tika izveidots algoritms, kas spēj apvienot visas nepieciešamās darbības, kā arī tiek pievienots R programmas kods. Darba nobeigumā tiks apskatīti arī praktiski piemēri, kuri spēs parādīt tās nozīmīgumu reālās dzīves situācijās.
Increased migraine-free intervals with multifocal repetitive transcranial magnetic stimulation.
2021
Introduction: Episodic migraine is a debilitating condition associated with vast impairments of health, daily living, and life quality. Several prophylactic treatments exist, having a moderate ratio of action related to side effects and therapy costs. Repetitive transcranial magnetic stimulation (rTMS) is an evidence based therapy in several neuropsychiatric conditions, showing robust efficacy in alleviating specific symptoms. However, its efficacy in migraine disorders is unequivocal and might be tightly linked to the applied rTMS protocol. We hypothesized that multifocal rTMS paradigm could improve clinical outcomes in patients with episodic migraine by reducing the number of migraine day…
Combining tDCS with prismatic adaptation for non-invasive neuromodulation of the motor cortex
2017
Abstract Background Prismatic adaptation (PA) shifts visual field laterally and induces lateralized deviations of spatial attention. Recently, it has been suggested that prismatic goggles are also able to modulate brain excitability, with cognitive after-effects documented even in tasks not necessarily spatial in nature. Objective The aim of the present study was to test whether neuromodulatory effects obtained from tDCS and prismatic goggles could interact and induce homeostatic changes in corticospinal excitability. Methods Thirty-four subjects were submitted to single-pulse transcranial magnetic stimulation (TMS) over the right primary motor cortex to measure Input-Output (IO) curve as a…
When nominal features are marked on verbs: A transcranial magnetic stimulation study
2006
It has been claimed that verb processing (as opposed to noun processing) is subserved by specific neural circuits in the left prefrontal cortex. In this study, we took advantage of the unusual grammatical characteristics of clitic pronouns in Italian (e.g., lo and la in portalo and portala 'bring it [masculine]/[feminine]', respectively)-the fact that clitics have both nominal and verbal characteristics, to explore the neural correlates of verb and clitic processing. We used repetitive transcranial magnetic stimulation (rTMS) to suppress the excitability of the left prefrontal cortex and to assess its role in producing verb+det+noun and verb+clitic phrases. Results showed an interference ef…
Illusory contours and specific regions of human extrastriate cortex: evidence from rTMS.
2003
Functional magnetic resonance imaging studies showed that perception of illusory contours is associated with extrastriate cortex activation prevailing on the right side. 1 Hz repetitive transcranial magnetic stimulation (rTMS) is able to induce lasting inhibition of cortical activity. The objective of the study was to investigate the role of extrastriate cortex in illusory contour perception inducing 1 Hz rTMS interference in healthy subjects. Eight healthy subjects underwent 1 Hz rTMS (600 pulses) through a figure-of-eight coil over right and left occipital cortex (O1 and O2 of 10/20 EEG system); sham magnetic stimulation on the same sites and right motor cortex rTMS (in three subjects) we…
Repetitive TMS of cerebellum interferes with millisecond time processing
2007
Time processing is important in several cognitive and motor functions, but it is still unclear how the human brain perceives time intervals of different durations. Processing of time in millisecond and second intervals may depend on different neural networks and there is now considerable evidence to suggest that these intervals are possibly measured by independent brain mechanisms. Using repetitive transcranial magnetic stimulation (rTMS), we determined that the cerebellum is essential in explicit temporal processing of millisecond time intervals. In the first experiment, subjects' performance in a time reproduction task of short (400-600 ms) and long (1,600-2,400 ms) intervals, were evalua…