Search results for "TP"

Effects of reading real versus print-out versions of multiple documents on students? sourcing and integrated understanding

2018

Abstract This study investigated the extent to which students’ sourcing and comprehension can be supported by the reading of real, as opposed to print-out versions of multiple documents. It was found that the reading of real rather than print-out versions of multiple documents on the issue of climate change increased students’ memory for source information and made them include more specific references to document sources in argument essays that they wrote about the issue. In turn, such increased sourcing in essays mediated the positive effect of reading real versus print-out versions of documents on students’ construction of coherent representations of the documents’ content information. T…

2020

X-chromosomal retinitis pigmentosa (RP) frequently is caused by mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. We evaluated the potential of PTC124 (Ataluren, TranslamaTM) treatment to promote ribosomal read-through of premature termination codons (PTC) in RPGR. Expression constructs in HEK293T cells showed that the efficacy of read-through reagents is higher for UGA than UAA PTCs. We identified the novel hemizygous nonsense mutation c.1154T > A, p.Leu385* (NM_000328.3) causing a UAA PTC in RPGR and generated patient-derived fibroblasts. Immunocytochemistry of serum-starved control fibroblasts showed the RPGR protein in a dot-like expression pattern along the primary…

Questions raised in science education : a Colombian-Spanish comparative study

2016

RESUMEN: La formulación de preguntas es un potente recurso para el aprendizaje de las ciencias. El objetivo del presente trabajo fue evaluar el desarrollo de la competencia metacognitiva por medio de la formulación de preguntas. En este estudio se usaron dos dispositivos experimentales de ciencias con un comportamiento inesperado. Se pidió a los participantes realizar preguntas destinadas a comprender su funcionamiento. La evaluación contrastó el desempeño de estudiantes colombianos con estudiantes españoles equivalentes. Los resultados mostraron que los colombianos formulan significativamente más preguntas en general, y más preguntas de alta calidad, que los estudiantes españoles. Se concl…

Discounting delayed monetary rewards and decision making in behavioral addictions - A comparison between patients with gambling disorder and internet…

2019

Abstract Behavior addictions, such as Gambling Disorder and Internet Gaming Disorder, have been demonstrated to have severe negative impact. Heightened impulsivity, deficits in decision making, and cognitive biases in the preference of immediate rewards have been shown to be crucial aspects in addictive disorders. While for Gambling Disorder (GD), dysfunctional decision making has been documented before, data for Internet Gaming Disorder (IGD) are still underrepresented. In order to allow for a direct comparison of both disorders, we assessed different measures of impulsivity (trait, impulsive choice, and decision making) in a clinical sample. N = 31 patients meeting criteria for GD and n =…

Relative expression of cholesterol transport-related proteins and inflammation markers through the induction of 7-ketosterol-mediated stress in Caco-…

2013

Human diets contain sterol oxidation products that can induce cytotoxic effects, mainly caused by cholesterol oxides. However, phytosterol oxides effects have been less extensively investigated. This study evaluates the production of inflammatory biomarkers (IL-1β, IL-8, IL-10, TNFα) and the influence of gene expression transporters and enzymes related to cholesterol absorption and metabolism (NPC1L1, ABCG5/8, HMGCoA, ACAT) produced by 7-ketosterols (stigmasterol/cholesterol) in Caco-2 cells. These effects were linked to intracellular signaling pathways by using several inhibitors. Results showed 7-ketostigmasterol to have a greater proinflammatory potential than 7-ketocholesterol. In non-p…

The VST Photometric Hα Survey of the Southern Galactic Plane and Bulge (VPHAS+)

2014

The VST Photometric Halpha Survey of the Southern Galactic Plane and Bulge (VPHAS+) is surveying the southern Milky Way in u, g, r, i and Halpha at 1 arcsec angular resolution. Its footprint spans the Galactic latitude range -5 < b < +5 at all longitudes south of the celestial equator. Extensions around the Galactic Centre to Galactic latitudes +/-10 bring in much of the Galactic Bulge. This ESO public survey, begun on 28th December 2011, reaches down to 20th magnitude (10-sigma) and will provide single-epoch digital optical photometry for around 300 million stars. The observing strategy and data pipelining is described, and an appraisal of the segmented narrowband Halpha filter in us…

Maintaining dignity in vulnerability: A qualitative study of the residents' perspective on dignity in nursing homes

2016

Postprint tilgjengelig 20.03.17. Background Older people, living in nursing homes, are exposed to diverse situations, which may be associated with loss of dignity. To help them maintain their dignity, it is important to explore, how dignity is preserved in such context. Views of dignity and factors influencing dignity have been studied from both the residents’ and the care providers’ perspective. However, most of these studies pertain to experiences in the dying or the illness context. Knowledge is scarce about how older people experience their dignity within their everyday lives in nursing homes. Aim To illuminate the meaning of maintaining dignity from the perspective of older people livi…

The high five: Associations of the five positive factors with the big five and well-being

2017

The study of individual differences in positive characteristics has mainly focused on moral traits. The objectives of this research were to study individual differences in positive characteristics from the point of view of the layperson, including non-moral individual characteristics, and to generate a replicable model of positive factors. Three studies based on a lexical approach were conducted. The first study generated a corpus of words which resulted in a refined list of socially shared positive characteristics. The second study produced a five-factor model of positive characteristics: erudition, peace, cheerfulness, honesty, and tenacity. The third study confirmed the model with a diff…

On the social meanings inherent in literacy campaigns

1990

Artikkelissa tarkastellaan luku- ja kirjoitustaitokampanjoita käsittelevän kansainvälisen dokumenttiaineiston perusteella sitä, millaisia merkityksiä sisältyy lukuja kirjoitustaidottomuuden määrittelyyn yhteiskunnalliseksi ongelmaksi, ja asetetaan kyseenalaiseksi tässä aineistossa ilmenevä yleismaailmallinen ideologia. Lisäksi pohditaan luku- ja kirjoitustaidon mahdollisista emansipatorista merkitystä kehitysmaiden oloissa.

In vivo evaluation of the interaction between the Escherichia coli IGP synthase subunits using the Bacterial Two-Hybrid system

2020

ABSTRACT Histidine biosynthesis is one of the most characterized metabolic routes for its antiquity and its central role in cellular metabolism; indeed, it represents a cross-road between nitrogen metabolism and de novo synthesis of purines. This interconnection is due to the activity of imidazole glycerol phosphate synthase, a heterodimeric enzyme constituted by the products of two his genes, hisH and hisF, encoding a glutamine amidotransferase and a cyclase, respectively. Despite their interaction was suggested by several in vitro experiments, their in vivo complex formation has not been demonstrated. On the contrary, the analysis of the entire Escherichia coli interactome performed using…