Search results for "TP"
showing 10 items of 4688 documents
The Lotus japonicus ROP3 Is Involved in the Establishment of the Nitrogen-Fixing Symbiosis but Not of the Arbuscular Mycorrhizal Symbiosis
2021
Legumes form root mutualistic symbioses with some soil microbes promoting their growth, rhizobia, and arbuscular mycorrhizal fungi (AMF). A conserved set of plant proteins rules the transduction of symbiotic signals from rhizobia and AMF in a so-called common symbiotic signaling pathway (CSSP). Despite considerable efforts and advances over the past 20 years, there are still key elements to be discovered about the establishment of these root symbioses. Rhizobia and AMF root colonization are possible after a deep cell reorganization. In the interaction between the model legume Lotus japonicus and Mesorhizobium loti, this reorganization has been shown to be dependent on a SCAR/Wave-like signa…
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and Cilia to Regulate Ciliogenesis and Ciliary Protein Traffic
2021
ABSTRACTELMODs are a family of three mammalian paralogs that display GTPase activating protein (GAP) activity towards a uniquely broad array of ADP-ribosylation factor (ARF) family GTPases that includes ARF-like (ARL) proteins. ELMODs are ubiquitously expressed in mammalian tissues, highly conserved across eukaryotes, and ancient in origin, being present in the last eukaryotic common ancestor. We described functions of ELMOD2 in immortalized mouse embryonic fibroblasts (MEFs) in the regulation of cell division, microtubules, ciliogenesis, and mitochondrial fusion. Here, using similar strategies with the paralogs ELMOD1 and ELMOD3, we identify novel functions and locations of these cell regu…
Passing the test of motherhood? Self‐esteem development and birth experience in the transition to motherhood : A longitudinal mixed methods study in …
2022
Aims To investigate women's childbirth experiences and their relation to self-esteem development in the postpartum year. Design A mixed methods study. Methods Women (N = 125) completed survey questionnaires regarding their self-esteem and childbirth experiences at three time points in 2020–2021: third trimester of pregnancy (T1), 4–8 weeks postpartum (T2) and 1 year postpartum (T3). The survey results were analysed using qualitative thematic and quantitative path analyses with latent change factors. The open-ended answers of the women who demonstrated a change in self-esteem between T2 and T3 were then compared. The STROBE checklist was used as the reporting guideline. Results The quantitat…
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018…
2018
Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean dia…
Implementing structured document production to support enterprise content management
2017
Within enterprise content management (ECM), the major goal is to develop and deploy systematic solutions for managing documents and other content items. ECM implementation concerns the development and deployment of new content management solutions and practices in an organization. Extensible Markup Language (XML) offers a standardized format for documents supporting the management and preservation of documents as structured documents. However, the deployment of XML may require a demanding standardization process, changes in work practices, and new tools for document management. Consequently, this research explores the implementation of structured document production environments. The focus …
Rakstītprasmes veicināšana sākumskolas skolēniem ar mācīšanās traucējumiem
2019
Diplomdarba autore Linda Spalva. Šobrīd autore studē Latvijas Universitātē, studiju programmā speciālās izglītības skolotājs/skolotājs logopēds. Paralēli studijām autore apmeklē dažādus kursus gan logopēdijā, gan speciālajā pedagoģijā. Kopš 2018.gada sākuma strādā vispārizglītojošā skolā par speciālo pedagogu. Diplomdarba tēma – Rakstītprasmes veicināšana sākumskolas skolēniem ar mācīšanās traucējumiem. Rakstītprasme ir viena no dzīves pamatprasmēm, ko skolēns apgūst skolā, tādēļ ļoti būtiski to izkopt un pilnveidot. Arvien biežāk nākas saskarties ar skolēniem, kuriem ir dažāda veida traucējumi, tādēļ nepieciešams noteikt traucējuma veidu un sniegt bērnam palīdzību. Diplomdarba mērķis ir te…
Sīkās pirkstu muskulatūras attīstīšana rakstītprasmes sekmēšanai 5 gadus veciem bērniem
2020
Kvalifikācijas darbu „Sīkās pirkstu muskulatūras attīstīšana rakstītprasmes sekmēšanai 5 gadus veciem bērniem” izstrādāja Latvijas Universitātes Pedagoģijas, psiholoģijas un mākslas fakultātes studente Marta Malnača. Darba mērķis ir izpētīt sīkās pirkstu muskulatūras attīstīšanas iespējas pirmsskolas izglītības iestādē 5 gadus veciem bērniem, ar mērķi sekmēt rakstītprasmes apguvi, kā arī, ar eksperta atzinuma metodi pārbaudīt darba autores izstrādātās uzdevumu kopas efektivitāti, kas tika izstrādāta, balstoties pedagogu anketu sniegtajās atbildēs un ieteikumos. Darbs sastāv no 4 nodaļām. Pirmajā nodaļā ir apkopota informācija par sīko pirkstu muskulatūru un tās attīstību. Otrajā nodaļā tiek…
3-4 gadīgu bērnu sīkās pirkstu muskulatūras attīstība rakstītprasmes apguvei pirmsskolā
2019
Darba nosaukums: 3-4 gadīgu bērnu sīkās pirkstu muskulatūras attīstība rakstītprasmes apguvei pirmsskolā. Darba autore: Anita Malceniece Darba mērķis ir teorētiski un praktiski izzināt 3-4 gadīgu bērnu sīkās pirkstu muskulatūras attīstīšanas iespējas rakstītprasmes apguvei pirmsskolā. Atbilstoši pētījuma mērķim ir izvirzīti pētījuma uzdevumi: 1.Analizēt pedagogu, psihologu un mediķu atziņas par sīko pirkstu muskulatūru. 2.Raksturot sīkās pirkstu muskulatūras attīstību 3-4 gadīgiem bērniem. 3.Organizēt empīrisko pētījumu, apkopot un analizēt iegūtos rezultātus. Pētījuma izstrādes gaita un tās rezultāti ir atspoguļoti 2 nodaļās un 5 apakšnodaļās. Pirmajā nodaļā tiek apkopota un analizēta zinā…
Genetic Factors as Promising Biomarkers of Sporadic Ascending Aortic Aneurysm
2014
Thoracic aorta shows various changes with advancing age and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur. VR and MD are typical entities of sporadic thoracic aortic aneurysm (TAA), actually considered a common and serious health risk and a pathology by unclear mechanisms. Increased activity of the coagulation system, inflammation, activation of extracellular matrix remodeling and endothelial dysfunction pathways have been recently evidenced to have a key role in its onset. Thus, polymorphisms of the coagulation system [fibrinogen (rs1800790); Factor II ( rs1799963); Factor V (rs6025); Factor VII (rs121964926)…
Absolute quantification of noncoding RNA by microscale thermophoresis
2019
Abstract Accurate quantification of the copy numbers of noncoding RNA has recently emerged as an urgent problem, with impact on fields such as RNA modification research, tissue differentiation, and others. Herein, we present a hybridization‐based approach that uses microscale thermophoresis (MST) as a very fast and highly precise readout to quantify, for example, single tRNA species with a turnaround time of about one hour. We developed MST to quantify the effect of tRNA toxins and of heat stress and RNA modification on single tRNA species. A comparative analysis also revealed significant differences to RNA‐Seq‐based quantification approaches, strongly suggesting a bias due to tRNA modifica…