Search results for "TPA"
showing 10 items of 770 documents
Akadēmiskā Dzīve, 56. rakstu krājums
2020
An
2020
Intracellular acid stress inhibits plant growth by unknown mechanisms and it occurs in acidic soils and as consequence of other stresses. In order to identify mechanisms of acid toxicity, we screened activation-tagging lines of Arabidopsis thaliana for tolerance to intracellular acidification induced by organic acids. A dominant mutant, sbt4.13-1D, was isolated twice and shown to over-express subtilase SBT4.13, a protease secreted into endoplasmic reticulum. Activity measurements and immuno-detection indicate that the mutant contains less plasma membrane H+-ATPase (PMA) than wild type, explaining the small size, electrical depolarization and decreased cytosolic pH of the mutant but not orga…
Zvaigžņotā Debess: 2018, Vasara (240)
2018
Jauna hipotēze par I tipa pārnovu izcelšanos ; No 108 minūtēm līdz 96 dienām ; Maiņzvaigznes (astronomija skolā) ; O.Dumbrājs. Nēteres teorēmai 100 gadu ; K.Švarcs. Jauni novērojumi tālā un tuvā kvazārā ; I.P. Īsumā: ALMA un VLT iegūst liecību par zvaigžņu veidošanos tikai 250 miljonus gadu pēc Lielā Sprādziena ; I.Pundure. Lagūnas miglājs – zvaigžņu bērnistaba Habla skatījumā ; I.Pundure. ALMA un APEX atklāj veidojošos galaktiku megasaplūšanu agrīnajā Visumā ; K.Salmiņš. LU Astronomijas institūts pirmais veicis nanopavadoņa S-NET lāzermērījumus ; J.Jaunbergs. Zeme atpakaļskata spogulī ; J.Jaunbergs. Sniegotā Helēne un mazais Polideiks ; R.Misa. Latvijas uzņēmums Eventech piedalīsies Luna-2…
Yamik Sinus Catheter in the Topical Treatment of Patients with Acute Rhinosinusitis after Previous Sinus Surgery
2002
Background The Yamik sinus catheter was designed as a new device for the topical treatment of rhinosinusitis. It creates intermittent positive and negative intranasal pressure after sealing the ipsilateral nostril and choana with two inflatable cuffs. Affecting the nasal cavity and all paranasal sinuses of one side at a time, it is used to evacuate mucous and secretions as well as and to introduce antiseptic, antibacterial, or antifungal solutions. Methods This study was designed to evaluate the effectiveness of the Yamik catheter in cases of acute purulent rhinosinusitis in patients who previously underwent endonasal sinus surgery for chronic rhinosinusitis. Twenty patients were treated at…
THU0469-HPR Sexual perception and sexual problems in patients with ankylosing spondylitis
2013
Background Ankylosing spondylitis (AS) is a chronic, systemic inflammatory rheumatic disease affecting the axial skeleton, but may also affect peripheral joints, tendons and internal organs. This disease which begins in the second or third decade may give rise to significant loss of function and impaired quality of life. Despite the known importance of sexuality as part of quality of life (1), only a few studies have explored this important issue in AS patients. Objectives To explore sexuality in patients with AS in regard to how satisfied they are with their sexual life and whether the patients think their sexuality is influenced by the disease. Methods This is a prospective, longitudinal,…
Sodium dynamics: another key to astroglial excitability?
2012
Astroglial excitability is largely mediated by fluctuations in intracellular ion concentrations. In addition to generally acknowledged Ca 2+ excitability of astroglia, recent studies have demonstrated that neuronal activity triggers transient increases in the cytosolic Na + concentration ([Na + ] i ) in perisynaptic astrocytes. These [Na + ] i transients are controlled by multiple Na + -permeable channels and Na + -dependent transporters; spatiotemporally organized [Na + ] i dynamics in turn regulate diverse astroglial homeostatic responses such as metabolic/signaling utilization of lactate and glutamate, transmembrane transport of neurotransmitters and K + buffering. In particular, near-me…
Sodium Fluxes and Astroglial Function
2012
Astrocytes exhibit their excitability based on variations in cytosolic Ca(2+) levels, which leads to variety of signalling events. Only recently, however, intracellular fluctuations of more abundant cation Na(+) are brought in the limelight of glial signalling. Indeed, astrocytes possess several plasmalemmal molecular entities that allow rapid transport of Na(+) across the plasma membrane: (1) ionotropic receptors, (2) canonical transient receptor potential cation channels, (3) neurotransmitter transporters and (4) sodium-calcium exchanger. Concerted action of these molecules in controlling cytosolic Na(+) may complement Ca(2+) signalling to provide basis for complex bidirectional astrocyte…
Understanding the influence of context in technology integration from teacher educators’ perspective
2021
The perspective of teachers is important for advancing the use of technology in classrooms. A considerable number of research studies have explained context in ways that have narrowed the understanding of its impact on successful technology integration. This study employs the Technological Pedagogical and Content Knowledge (TPACK) model as a lens in understanding factors influencing teachers’ integration of technology in classrooms. Data were collected using focused interviews of 19 teacher educators of three colleges of education from the southern part of Nigeria. The results reveal that among the level contexts, the meso level presented the most challenges to teachers’ efforts at integrat…
Effects of ouabain on human bronchial muscle in vitro
2003
The effects of ouabain, an inhibitor of the plasmalemmal Na(+)/K(+)-ATPase activity, were examined in human isolated bronchus. Ouabain produced concentration-dependent contraction with -logEC(50)=7.16+/-0.11 and maximal effect of 67+/-4% of the response to acetylcholine (1 mM). Ouabain (10 microM)-induced contraction was epithelium-independent and was not depressed by inhibitors of cyclooxygenase and lipoxygenase, antagonists of muscarinic, histamine H(1)-receptors and alpha-adrenoceptors, or neuronal Na(+) channel blockade. The inhibition of ouabain contraction in tissues bathed in K(+)-free medium, and the inhibition by ouabain of the K(+)-induced relaxation confirm that the contractile a…
„Luminor bankas" komunikācija stratēģija un auditorijas reakcija uz „DNB banka" un „Nordea banka" apvienošanos
2018
Bakalaura darba tēma ir „Luminor bankas” komunikācija stratēģija un auditorijas reakcija uz „DNB banka” un „Nordea banka”. Darbs sastāv no trīs daļām - teorētiskās, metodoloģiskās un empīriskās daļas. Darba mērķis ir izpētīt teorētisko informāciju par zīmolu, tā identitāti, atpazīstamību, kā arī par zīmolu apvienošanu jaunā zīmolā „Luminor”. Tiks veikta banku klientu viedokļu apkopošana un izpētīta „Luminor bankas” komunikācija ar auditoriju. Darbs ir sadalīts trijās lielās nodaļās, kur pirmā nodaļa ir teorētiskā daļa, otrā metodoloģiskā daļa un trešā empīriskā daļa. Visām šīm nodaļām ir izveidotas arī apakšnodaļas. Pētījuma objekts ir jaunizveidotā banka „Luminor”, kura radusies divu banku…