Search results for "TPA"
showing 10 items of 770 documents
Pacienta un ambulatorās aprūpes māsas sadarbība melanomas riska mazināšanā
2020
Melanomas gadījumu skaits ik gadu pieaug un ambulatorās aprūpes māsām jābūt kompetentām, izglītojot pacientus. Sakarā ar melanomas bīstamību un gadījumu skaita pieaugšanu tika izvēlēta tēma un izveidots pētījums, lai noskaidrotu kādas ir izglītošanas īpatnības ambulatorās aprūpes māsām. Galvenie pētniecības uzdevumi ir izpētīt literatūru atbilstoši izvirzītajai tēmai par melanomu un profilaksi ambulatorās aprūpes māsas praksē. Analizēt Virdžīnijas Hendersones pamatvajadzību teoriju, izstrādāt pētījuma instrumentu, veikt pētījumu un apkopot iegūtos rezultātus, balstoties uz iegūtajiem rezultātiem, izdarīt secinājumu. Pētījuma mērķis - noskaidrot iespējamo pacienta un māsas sadarbību melanoma…
Análisis e Interpretación de las características ecofisiológicas de las poblaciones de mejillón cebra (Dreissena polymorpha) en los ríos Ebro y Mijar…
2022
El objetivo de la presente Tesis doctoral ha sido analizar e interpretar la información relativa a la ecofisiología de varias poblaciones españolas de mejillón cebra (Dreissena polymorpha) en diferentes puntos del río Ebro y en el embalse de Sitjar del rio Mijares recogidas en el año 2009 dentro del proyecto:” Estudio de la estructura genética y diferenciación ecológica de las poblaciones españolas del mejillón cebra (Dreissena polymorpha) frente a factores ambientales de origen natural y antropogénico. Bases científicas para su control ambiental sostenible (CEBRAPOP)”. Se han comparado los parámetros fisiológicos, bioquímicos y de expresión proteica de cada una de las poblaciones, así como…
ADAS gājēju atpazīšana apvienojot punktu mākoni ar termiskām bildēm
2016
Ļoti daudz cilvēku cieš satiksmes negadījumu dēļ un tas ir viens no galvenajiem iemesliem progresīvo autovadītāju atbalsta sistēmu (ADAS) popularitātei – jo sevišķi gājēju atpazīšanai, kas ir viens paveids no tās. Neskatoties uz lielo pieprasījumu, esošajās sistēmas ir daudz neatrisinātas problēmas un ir vieta uzlabojumiem. Darba mērķis ir aprakstīt ADAS, noskaidrot labākos risinājumus gājēju atpazīšanā un praktiski veikt gājēju atpazīšanas risinājuma izveidi, kurš izmanto stereo kameras datus ar termālās kameras attēliem. Darbā tika aprakstītas ADAS, gājēju atpazīšanas attīstība un šobrīd labākie risinājumi. Tika veikta piedāvātās metodes risinājuma izpēte un izstrāde. Rezultātā tika radīt…
RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations
2020
Autophagy is dependent on appropriate lipid supply for autophagosome formation. The regulation of lipid acquisition and the autophagy network response to lipid-limiting conditions are mostly elusive. Here, we show that the knockout of the RAB GTPase RAB18 interferes with lipid droplet catabolism, causing an impaired fatty acid release. The resulting reduced lipid-droplet-derived lipid availability influences autophagy and provokes adaptive modifications of the autophagy network. These adjustments include increased expression and phosphorylation of ATG2B as well as augmented formation of the ATG12-ATG5 conjugate. Moreover, ATG9A shows an enhanced phosphorylation at amino acid residues tyrosi…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
2010
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…
Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
2004
The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFN beta, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFN beta promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, I kappa B kinase- and TANK-binding kina…
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
2002
In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…
Retroreflektīvo pazīšanas zīmju pamanīšana skotopiskos un mezopiskos apstākļos
2015
Maģistra darbs ir uzrakstīts latviešu valodā uz 61 lapām, satur 40 attēlus, 7 tabulas, 16 atsauces uz literatūras avotiem un 3 pielikumus. Darba mērķis: Izveidot un aprobēt laboratorijas metodiku, kas ļautu novērtēt retroreflektīvu uzšuvju uz gājēju apğērba atpazīšanu un mērīt atpazīšanas apgaismojuma sliekšņus, izmantojot konstanto stimula metodi ar alternatīvu piespiedu izvēles metodi. Izvirzīt secinājumus par subjektīviem apstākļiem, pie kuriem satiksmes dalībnieki atpazīst gājējus, tiem izmantojot retroreflektīvas uzšuves. Dalībnieki: Eksperimentā piedalījās 5 dalībnieki vecumā no 23 līdz 36 gadiem. Dalībnieki piedalījās eksperimentā bez redzes korekcijas līdzekļiem, izņemot divus, kam …
Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia
2011
Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia The aim of the study was to characterise coronary artery disease (CAD) outpatients in Latvia by risk factors (RF) including heart rate (HR), physical examination data, clinical data and treatment. Twelve practitioners had each examined and questioned 6 to 12 patients with established CAD (n = 120). The most frequent cardiovascular (CV) RF and co-morbidity were dyslipidemia (94.2%) and hypertension (78.3%), respectively. Prevalence of increased resting HR (≥70 bpm) was 35.9% and 33.6%, when measured by pulse palpation and electrocardiography, respectively. Regarding other RFs, prevalence of treated…