Search results for "TRANSFORMATION"

A basic analysis toolkit for biological sequences

2007

This paper presents a software library, nicknamed BATS, for some basic sequence analysis tasks. Namely, local alignments, via approximate string matching, and global alignments, via longest common subsequence and alignments with affine and concave gap cost functions. Moreover, it also supports filtering operations to select strings from a set and establish their statistical significance, via z-score computation. None of the algorithms is new, but although they are generally regarded as fundamental for sequence analysis, they have not been implemented in a single and consistent software package, as we do here. Therefore, our main contribution is to fill this gap between algorithmic theory an…

COMPUTER AIDED ENGINEERING FOR THERMO-MECHANICAL-METALLURGICAL ANALYSIS OF FORGING OPERATIONS OF TITANIUM ALLOYS

In this thesis a study on the forging processes of Ti-6Al-4V titanium alloy, with particular focus on the numerical applications and simulation design of hot forming methods, was done. The aim of this work is to collect all data concerning the material definition in terms of thermal, mechanical and microstructural properties of the selected alloy in order to filter all useful information to describe the behavior of the material under the characteristic conditions of the hot forging processes, taking into account both thermo-mechanical and metallurgical aspects involved during a such complex thermo-mechanical stage. Those information were collected and used to characterize the material prope…

Phylogenetic analysis of the isopenicillin-N-synthetase horizontal gene transfer.

1996

A phylogenetic study of the isopenicillin-N-synthetase (IPNS) gene sequence from prokaryotic and lower eukaryotic producers of beta-lactam antibiotics by means of a maximum-likelihood approach has been carried out. After performing an extensive search, rather than invoking a global molecular clock, the results obtained are best explained by a model with three rates of evolution. Grouped in decreasing order, these correspond to A. nidulans and then to the rest of the eukaryotes and prokaryotes, respectively. The estimated branching date between prokaryotic and fungal IPNS sequences (852 +/- 106 MY) strongly supports the hypothesis that the IPNS gene was horizontally transferred from bacteria…

Metallurgical Evolutions in Hot Forging of Dual Phase Titanium Alloys: Numerical Simulation and Experiments

2015

Titanium forging has been encountering a growing interest in the scientific and industrial communities because of the distinct advantages it provides with respect to machining, in terms of both mechanical properties of the product and material waste, thus significantly reducing the Buy to Fly ratio. In the paper, a numerical FE model, based on a tri-coupled approach and able to predict the microstructural evolutions of the workpiece during the process, is developed and set up. Calculated results are compared to experiments for a few industrial case studies. The final phases distribution in the forged parts is experimentally measured and compared to the FE model output finding satisfying ove…

Measurement of the W boson polarization in top quark decays with the ATLAS detector

2012

This paper presents measurements of the polarization of W bosons in top quark decays, derived from t¯t events with missing transverse momentum, one charged lepton and at least four jets, or two charged leptons and at least two jets. Data from pp collisions at a centre-of-mass energy of 7 TeV were collected with the ATLAS experiment at the LHC and correspond to an integrated luminosity of 1.04 fb−1. The measured fractions of longitudinally, left- and right-handed polarization are F0 = 0.67 ± 0.07, FL = 0.32 ± 0.04 and FR = 0.01 ± 0.05, in agreement with the Standard Model predictions. As the polarization of the W bosons in top quark decays is sensitive to the Wtb vertex Lorentz structure and…

Search for light scalar top quark pair production in final states with two leptons with the ATLAS detector in sqrt(s) = 7 TeV proton-proton collisions

2012

A search is presented for the pair production of light scalar top quarks in s√=7 TeV proton–proton collisions recorded with the ATLAS detector at the Large Hadron Collider. This analysis uses the full data sample collected during 2011 running that corresponds to a total integrated luminosity of 4.7 fb[superscript −1]. Light scalar top quarks are searched for in events with two opposite-sign leptons (e, μ), large missing transverse momentum and at least one jet in the final state. No excess over Standard Model expectations is found, and the results are interpreted under the assumption that the light scalar top decays to a b-quark in addition to an on-shell chargino whose decay occurs through…

Locally compact (2, 2)-transformation groups

2010

We determine all locally compact imprimitive transformation groups acting sharply 2-transitively on a non-totally disconnected quotient space of blocks inducing on any block a sharply 2-transitive group and satisfying the following condition: if Δ1, Δ2 are two distinct blocks and Pi, Qi ∈ Δi (i = 1, 2), then there is just one element in the inertia subgroup which maps Pi onto Qi. These groups are natural generalizations of the group of affine mappings of the line over the algebra of dual numbers over the field of real or complex numbers or over the skew-field of quaternions. For imprimitive locally compact groups, our results correspond to the classical results of Kalscheuer for primitive l…

Pedogenesis and carbon sequestration in transformed agricultural soils of Sicily

2021

The increasing atmospheric CO2 concentration is a consequence of human activities leading to severe environmental deteriorations. Techniques are thus needed to sequester and reduce atmospheric carbon. One of the proposed techniques is the transformation or construction of new soils into which more organic carbon can be sequestered and CO2 be consumed by increased weathering. By using a chronosequence of new and transformed soils on crushed limestone (0–48 years) in a Mediterranean area (Sicily), we tried to quantify the amount of organic carbon that could be additionally sequestered and to derive the corresponding rates. A further aim was to trace chemical weathering and related CO2 consump…

Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and …

2015

AbstractAdult T-cell leukemia/lymphoma is a highly infiltrative neoplasia of CD4+ T-lymphocytes that occurs in about 5% of carriers infected with the deltaretrovirus human T-cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax perturbs cellular signaling pathways leading to upregulation of host cell factors, amongst them the actin-bundling protein Fascin, an invasion marker of several types of cancer. However, transcriptional regulation of Fascin by Tax is poorly understood. In this study, we identified a triple mode of transcriptional induction of Fascin by Tax, which requires (1) NF-κB-dependent promoter activation, (2) a Tax-responsive region in the Fascin promoter, and (3) a p…

TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

2007

The epithelial-to-mesenchymal transition (EMT) is a crucial process, occurring both during development and tumor progression, by which an epithelial cell undergoes a conversion to a mesenchymal phenotype, dissociates from initial contacts and migrates to secondary sites. We recently reported that in hepatocytes the multifunctional cytokine TGFβ induces a full EMT characterized by (i) Snail induction, (ii) E-cadherin delocalization and down-regulation, (iii) down-regulation of the hepatocyte transcriptional factor HNF4α and (iv) up-regulation of mesenchymal and invasiveness markers. In particular, we showed that Snail directly causes the transcriptional down-regulation of E-cadherin and HN…