Search results for "TRANSFORMATION"
showing 10 items of 1634 documents
Hybrid kernel estimates of space-time earthquake occurrence rates using the Etas model
2010
The following steps are suggested for smoothing the occurrence patterns in a clustered space–time process, in particular the data from an earthquake catalogue. First, the original data is fitted by a temporal version of the ETAS model, and the occurrence times are transformed by using the cumulative form of the fitted ETAS model. Then the transformed data (transformed times and original locations) is smoothed by a space–time kernel with bandwidth obtained by optimizing a naive likelihood cross-validation. Finally, the estimated intensity for the original data is obtained by back-transforming the estimated intensity for the transformed data. This technique is used to estimate the intensity f…
The role of the $\Delta(1232)$-resonance in covariant baryon chiral perturbation theory
2013
We stress, on theoretical and phenomenological grounds, the importance of the $\Delta(1232)$-resonance in a chiral effective field theory approach applied to the study of $\pi N$ scattering. We show how its inclusion as a dynamical degree of freedom allow us to obtain reliably valuable information from $\pi N$ scattering data.
Reflectance-based surface saliency
2017
In this paper, we propose an original methodology allowing the computation of the saliency maps for high dimensional RTI data (Reflectance Transformation Imaging). Unlike most of the classical methods, our approach aims at devising an intrinsic visual saliency of the surface, independent of the sensor (image) and the geometry of the scene (light-object-camera). From RTI data, we use the DMD (Discrete Modal Decomposition) technique for the angular reflectance reconstruction, which we extend by a new transformation on the modal basis enabling a rotation-invariant representation of reconstructed reflectances. This orientation-invariance of the resulting reflectance shapes fosters a robust esti…
Experimental Evaluation of the Performance of a Three-Phase Five-Level Cascaded H-Bridge Inverter by Means FPGA-Based Control Board for Grid Connecte…
2018
Over the last decades, plants devoted to the generation of green energy significantly increased their number, together with the demand of same electrical energy, also stored in battery systems. This fact produced the growth of energy conversion systems with advanced performances with respect to the traditional ones. In this circumstance, multilevel converters play a significant role for their great advantages in performances, flexibility, fault-tolerability, employment of renewable energy sources and storage systems and finally yet importantly reduced filter requirements. In this context, this paper faces the performance of a cascaded H-bridge 5 level inverter in terms of harmonic distortio…
Charging a Capacitor from an External Fluctuating Potential using a Single Conical Nanopore
2015
We explore the electrical rectification of large amplitude fluctuating signals by an asymmetric nanostructure operating in aqueous solution. We show experimentally and theoretically that a load capacitor can be charged to voltages close to 1 V within a few minutes by converting zero time-average potentials of amplitudes in the range 0.5–3 V into average net currents using a single conical nanopore. This process suggests that significant energy conversion and storage from an electrically fluctuating environment is feasible with a nanoscale pore immersed in a liquid electrolyte solution, a system characteristic of bioelectronics interfaces, electrochemical cells, and nanoporous membranes.
Mathematical Modelling of In-sewer Processes as a Tool for Sewer System Design
2018
The objective of this paper is to evaluate the potential impact of in-sewer processes (COD components transformation and hydrogen sulphide production) on the design of sewer systems. The tool used for such analysis is a mathematical model derived from the WATS model (Wastewater Aerobic/anaerobic Transformation in Sewers) able to describe the processes occurring in the sewer system both under aerobic and anaerobic conditions. The model is applied to three synthetic catchments with, respectively, 10,000, 50,000 and 250,000 inhabitants connected to gravity sewer systems different in terms of type (separate or combined), slope, length, travel time, wastewater temperature. The simulation results…
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Bisoprolol Fumarate
2014
Abstract Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing bisoprolol as the sole active pharmaceutical ingredient (API) are reviewed. Bisoprolol is classified as a Class I API according to the current Biopharmaceutics Classification System (BCS). In addition to the BCS class, its therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability problems are taken into consideration. Qualitative compositions of IR tablet dosage forms of bisoprolol with a marketing authorization (MA) in ICH (Inter…
Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes
2011
author cannot archive publisher's version/PDF; International audience; Bisphenol F (BPF) is present in the environment and as a contaminant of food. Humans may, therefore, be exposed to BPF, and an assessment of this risk is required. BPF has been shown to have genotoxic and endocrine-disruptor properties in a human hepatoma cell line (HepG2), which is a model system for studies of xenobiotic toxicity. In this study, we investigated the ability of HepG2 cells to biotransform BPF, because metabolism may affect the observed effects of BPF, and we compared this metabolic capacity with that of human hepatocytes. Cells were incubated for 24 hours with [(3)H]-BPF. The culture medium was then conc…
The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state
2012
AbstractMiR-125b-1 maps at 11q24, a chromosomal region close to the epicenter of 11q23 deletions in chronic lymphocytic leukemias (CLLs). Our results establish that both aggressive and indolent CLL patients show reduced expression of miR-125b. Overexpression of miR-125b in CLL-derived cell lines resulted in the repression of many transcripts encoding enzymes implicated in cell metabolism. Metabolomics analyses showed that miR-125b overexpression modulated glucose, glutathione, lipid, and glycerolipid metabolism. Changes on the same metabolic pathways also were observed in CLLs. We furthermore analyzed the expression of some of miR-125b–target transcripts that are potentially involved in the…
Target point calculation in the computerized tomography. Comparison of different stereotactic methods
1995
The adaptation of computerized tomography for stereotactic operations requires the transformation of the coordinates of the target point from the CT image space into the stereotactic frame space. Two basic solutions for this transformation are realized in the most of the contemporary stereotactical systems. The indirect geometric method adjusts the frame coordinate system mechanically and identifies its origin in the CT image. There are 6 degrees of freedom: 3 of rotation and 3 of translation which have to be taken into consideration. The second method is a based on direct algebraic coordinate transformation and is independent of the explicite knowledge of the relationship between the image…