Search results for "TRANSLATION"

Wole Soyinka: Due Poesie

2008

Durante l'undicesima edizione del Festivaletteratura di Mantova, nel settembre 2007, Wole Soyinka, insieme alla studiosa e traduttrice Alessandra Di Maio, ha ripercorso la sua carriera poetica, spiegandone svolte e sviluppi. In questa sede si riportano due delle sue poesie più note in traduzione -- "Conversazione telefonica" e "I figli di questa terra" -- che coprono idealmente l'arco della sua produzione poetica, dalla gioventù all'eta matura.

The Role of Translation and EU-Texts in the English BA Programme : Exploring Hungarian College Graduates' Work Experiences and Views

2015

Despite recent convincing arguments emphasizing the benefits of using translation in foreign language learning and teaching, there is little empirical research focusing on existing educational practices. This study aims to fill this gap by investigating the case of an English bachelor’s programme at a Hungarian college, which has integrated translation and specialised EU-texts into the curriculum in a systematic way in an attempt to stay abreast of the current global social transformations and address local needs. The participants of the survey were graduates of the English BA programme who have completed the optional EU specialisation module. The research aimed to find out about graduates’…

Traps N' Clots: NET-Mediated Thrombosis and Related Diseases.

2020

The emergence of drug resistance to targeted cancer therapies: Clinical evidence.

2019

For many decades classical anti-tumor therapies included chemotherapy, radiation and surgery; however, in the last two decades, following the identification of the genomic drivers and main hallmarks of cancer, the introduction of therapies that target specific tumor-promoting oncogenic or non-oncogenic pathways, has revolutionized cancer therapeutics. Despite the significant progress in cancer therapy, clinical oncologists are often facing the primary impediment of anticancer drug resistance, as many cancer patients display either intrinsic chemoresistance from the very beginning of the therapy or after initial responses and upon repeated drug treatment cycles, acquired drug resistance deve…

A critical review of the bibliography on the History of Translation in Spain

2013

This article deals critically and succinctly with the development of the studies on translation history in Spain, starting from counting the bibliographic production (researches, studies, articles, publications, etc.). Given the existing thematic dispersion and the increase that these studies have experienced in the last few decades, this historiographical review highlights the need for a synthesis in future works establishing periods and classification in order to provide a panoramic and practical view to research and theorizing.  |  El articulo aborda de forma critica y sucinta el recorrido de los estudios sobre historia de la traduccion en Espana, partiendo tanto de los hitos bibliografi…

Global translational repression induced by iron deficiency in yeast depends on the Gcn2/eIF2α pathway

2020

Iron is an essential element for all eukaryotic organisms because it participates as a redox active cofactor in a wide range of biological processes, including protein synthesis. Translation is probably the most energy consuming process in cells. Therefore, one of the initial responses of eukaryotic cells to stress or nutrient limitation is the arrest of mRNA translation. In first instance, the budding yeast Saccharomyces cerevisiae responds to iron deficiency by activating iron acquisition and remodeling cellular metabolism in order to prioritize essential over non-essential iron-dependent processes. We have determined that, despite a global decrease in transcription, mRNA translation is a…

Subcellular targeting of multiligand-binding protein gC1qR.

1999

Abstract gC1q receptor, a protein originally described as the cell surface receptor for the globular heads of complement factor C1q, has been found to bind human H-kininogen with high affinity and specificity. Therefore, gC1qR has been considered candidate kininogen docking site on the surfaces of platelets, neutrophils and endothelial cells. Recent work demonstrating that gC1qR is an intracellular protein that is tightly associated with mitochondria rather than targeted to the cell surface has challenged this view. To further probe cellular trafficking routes of gC1qR, we overexpressed human gC1qR in a mammalian cell and monitored cell surface exposure of recombinant gC1qR by virtue of its…

The evolving role of platelets in inflammation.

2003

Platelets are small in size and simple in structure. Nevertheless, these anucleate cytoplasts utilize complex molecular systems to regulate a variety of biological functions. Here we review evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that interface thrombosis with inflammation and potentially identify new roles in inflammatory diseases.

For the use of sound. Film sound analysis for audio-description: some key issues

2012

This article aims to outline the issues involved in the production and reception of film sound with a view to identifying its challenges for audio-description (AD). It thereby hopes to provide insights into the way in which a careful analysis and integration of film sound and sound effects are required for the production of coherence in AD, if it is to function as part of a new filmic text. However, the article also points to the limits of analysis and interpretation, and to the need for reception research as well as collaboration with visually impaired users. A detailed analysis of a scene from Saving Private Ryan (Spielberg 1998), a film that won an Oscar for best sound effect editing, de…

Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts

2021

Abstract Background Ciliary dysfunction underlies a range of genetic disorders collectively termed ciliopathies, for which there are no treatments available. Bardet-Biedl syndrome (BBS) is characterised by multisystemic involvement, including rod-cone dystrophy and renal abnormalities. Together with Alstrom syndrome (AS), they are known as the ‘obesity ciliopathies’ due to their common phenotype. Nonsense mutations are responsible for approximately 11% and 40% of BBS and AS cases, respectively. Translational readthrough inducing drugs (TRIDs) can restore full-length protein bypassing in-frame premature termination codons, and are a potential therapeutic approach for nonsense-mediated ciliop…