Search results for "TRIP"
showing 10 items of 2134 documents
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis
2019
CTSD (cathepsin D) is one of the major lysosomal proteases indispensable for the maintenance of cellular proteostasis by turning over substrates of endocytosis, phagocytosis and autophagy. Consequently, CTSD deficiency leads to a strong impairment of the lysosomal-autophagy machinery. In mice and humans CTSD dysfunction underlies the congenital variant (CLN10) of neuronal ceroid lipofuscinosis (NCL). NCLs are distinct lysosomal storage disorders (LSDs) sharing various hallmarks, namely accumulation of protein aggregates and ceroid lipofuscin leading to neurodegeneration and blindness. The most established and clinically approved approach to treat LSDs is enzyme replacement therapy (ERT) aim…
STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation
2019
Summary Adult stem cells reactivate from quiescence to maintain tissue homeostasis and in response to injury. How the underlying regulatory signals are integrated is largely unknown. Drosophila neural stem cells (NSCs) also leave quiescence to generate adult neurons and glia, a process that is dependent on Hippo signaling inhibition and activation of the insulin-like receptor (InR)/PI3K/Akt cascade. We performed a transcriptome analysis of individual quiescent and reactivating NSCs harvested directly from Drosophila brains and identified the conserved STRIPAK complex members mob4, cka, and PP2A (microtubule star, mts). We show that PP2A/Mts phosphatase, with its regulatory subunit Widerbors…
Effect of Propolis mouthwash on plaque and gingival indices over fixed orthodontic patients
2019
Background In patients with fixed orthodontics, the presence of orthodontic appliances causes dental plaque accumulation and hygiene problems. The purpose of this study was to evaluate the effect of Propolis and chlorhexidine mouthwashes on plaque and gingival indices in patients who are undergoing orthodontic treatment. Material and Methods In this triple blind study, in total, 37 patients aged from 15 to 35 years those who have been undergoing fixed orthodontic treatment were studied. After that, one of the mouthwashes that containing either Propolis or Chlorhexidine was randomly prescribed to patients. The patients were asked to use mouthwashes twice a day after brushing their teeth for …
The influence of corporate governance's decision on corporate social responsibility
2018
The need for an accurate and detailed disclosure, the need to understand the mechanisms of government under which the company is managed and controlled, are the starting point of the choices of the many stakeholders that revolve around the company. A large number of players is interested in corporate governance are among these, not only the major shareholders, but also an increasing number of small investors. CSR is an extension of firms efforts to foster effective corporate governance, ensuring firms sustainability via sound business practices that promote accountability and transparency. rnThe paper aims to explore the impact that various corporate governance mechanisms have on the commit…
School Bike Sharing Program: will it Succeed?
2020
Abstract Encouraging active and sustainable transport modes in order to limit the excessive use of cars, as well as reducing pollutant emissions and creating livable urban environments, has become one of the priorities for policymakers in recent years. The introduction of innovative systems increasingly being introduced in modern cities, such as bike sharing, can certainly contribute to the spread of cycling and thus allow a radical change in the mobility habits of their citizens. This can be especially true for high-school students who are often otherwise accompanied by their parents with private cars. This article aims to assess the influence that a bike sharing program for students has o…
Connotative meaning of travel modes and activity-travel behavior
2018
Abstract This paper aims to present results of a study regarding how the meaning of travel modes influences on the performance of activities and trips. Connotative meaning of travel modes was measured using semantic differential scales, which collect the suggestive significance of the terms used to name current travel modes. More than 400 people provided that information together with values and other types of attitudes, characteristics of their usual companions, socio-demographics, and 2-days activity-travel diary that includes a weekend day and a weekday. Descriptive analysis, which include frequency distributions, Factor Analysis, and correlations, have been developed to find potential r…
Can copper(II) mediate Hoogsteen base-pairing in a left-handed DNA duplex? A pulse EPR study
2010
Pulse EPR spectroscopy is sued to investigate possible structural features of the copper(II) ion coordinated to poly(dG-dC) poly(dG-dC) in a frozen aqueous solution, and the structural change of the polynucleotide induced by the presence of the metal ion. Two different copper species were identified and their geometry explained by a molecular model. According to this model, one species is exclusively coordinated to a single guanine with the N7 nitrogen atom forming a coordinative bond with the copper. In the other species, a guanine and a cytosine form a ternary complex together with the copper ion. A copper crosslink between the N7 of guanine and N3 of cytosine is proposed as the most prob…
Towards sustainable servicescape : tourists’ perspectives of accommodation service attributes
2023
The study uses content analysis to identify the sustainable attributes in 678 accommodation reviews from Finnish and Russian tourists published on the Tripadvisor website and examines the sustainability perceptions of these tourist groups. The servicescape framework was applied to the structuring of the attributes indicating sustain-ability in accommodation services. The sustainable attributes highlighted in the reviews were more frequently in the physical rather than in the social servicescape factor. The tourists also reported environmental sustainability attributes more often than those related to social, cultural and economic sustainability. Overall, the sustainable attributes were perc…
CCDC 1572932: Experimental Crystal Structure Determination
2020
Related Article: Błażej Dziuk, Borys Ośmiałowski, Bartosz Zarychta, Krzysztof Ejsmont, Lilianna Chęcińska|2019|Crystals|9|662|doi:10.3390/cryst9120662
CCDC 1862873: Experimental Crystal Structure Determination
2018
Related Article: A. Zagidullin, D. Islamov, E. Oshchepkova, P. Lonnecke, V. Miluykov|2018|Acta Crystallogr.,Sect.E:Cryst.Commun.|74|1336|doi:10.1107/S2056989018011775