Search results for "TRIPLE"
showing 10 items of 506 documents
Exploring two-state reaction pathways in the photodimerization of cyclohexadiene.
2006
The ground- (S0) and lowest triplet-state (T1) pathways associated with dimerization of cyclohexadiene to give [2+2] and [4+2] cycloadducts have been theoretically studied at the UBLYP and UB3LYP levels of theory with the 6-31G* basis set. The DFT energies were validated by CCSD(T) single-point energy calculations. These cycloaddition reactions follow stepwise mechanisms with formation of bis-allylic biradical (BB) intermediates. In the S0 ground state, the interaction between two cyclohexadiene molecules with formation of BB intermediate IN(S0) has a large activation enthalpy of 32.0 kcal mol(-1). On the other hand, C-C bond-formation in the lowest triplet state (T1) leading to BB intermed…
ChemInform Abstract: Chemical and Spectroscopical Properties of Medium Sized trans- and cis- Bicyclo(n.1.0)alk-2-ynes.
2010
Chemical and spectroscopical properties of cis- and trans-cyclopropano-anellated cycloalkynes of medium ring size are investigated and compared with results from force field calculations. IR and 13C-NMR data of the alkynes reflect the deformation of the triple bond due to ring strain. Parallel to bending the reactivity increases with decreasing ring size, the trans fused alkynes prove to be nearly as reactive as the cis fused with a two carbon smaller ring size. The bicycloalkynes are complexed with silver triflate. 13C NMR reveals that the triple bond as well as the cyclopropane serve as ligands.
Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case–control EpiGEICAM study
2014
BACKGROUND: Although there are solid findings regarding the detrimental effect of alcohol consumption, the existing evidence on the effect of other dietary factors on breast cancer (BC) risk is inconclusive. This study aimed to evaluate the association between dietary patterns and risk of BC in Spanish women, stratifying by menopausal status and tumour subtype, and to compare the results with those of Alternate Healthy Index (AHEI) and Alternate Mediterranean Diet Score (aMED). METHODS: We recruited 1017 incident BC cases and 1017 matched healthy controls of similar age (±5 years) without a history of BC. The association between 'a priori' and 'a posteriori' developed dietary patterns and B…
Cholesterol-Inulin Conjugates for Efficient SN38 Nuclear Delivery: Nanomedicines for Precision Cancer Therapy
2022
An amphiphilic inulin-thiocholesterol conjugate (INU-Cys-TC) was strategically designed as a biodegradable core-shell nanocarrier of 7-ethyl-10-hydroxy-camptothecin (SN38) to enhance its solubility and stability in aqueous media, thus exploiting its brilliant anticancer effect. INU-Cys-TC was designed to have the hydrophilic inulin backbone (external shell) partially functionalized with hydrophobic thiocholesterol moieties (internal core) through a biodegradable disulfide bond due to cysteamine bridges. Thiocholesterol moieties impair redox-sensitive self-assembling abilities, yielding to nano-sized micelles in aqueous media capable of efficiently encapsulating a high amount of SN38 (DL = 8…
Nitric Oxide-Releasing Drug Glyceryl Trinitrate Targets JAK2/STAT3 Signaling, Migration and Invasion of Triple-Negative Breast Cancer Cells
2021
Triple-negative breast cancer (TNBC) is a highly aggressive disease with invasive and metastasizing properties associated with a poor prognosis. The STAT3 signaling pathway has shown a pivotal role in cancer cell migration, invasion, metastasis and drug resistance of TNBC cells. IL-6 is a main upstream activator of the JAK2/STAT3 pathway. In the present study we examined the impact of the NO-donor glyceryl trinitrate (GTN) on the activation of the JAK2/STAT3 signaling pathway and subsequent migration, invasion and metastasis ability of TNBC cells through in vitro and in vivo experiments. We used a subtoxic dose of carboplatin and/or recombinant IL-6 to activate the JAK2/STAT3 signaling path…
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin
2021
Antimicrobial peptides (AMPs) found in the innate immune system of a wide range of organisms might prove useful to fight infections, due to the reported slower development of resistance to AMPs. Increasing the cationicity and keeping moderate hydrophobicity of the AMPs have been described to improve antimicrobial activity. We previously found a peptide derived from the Tribolium castaneum insect defensin 3, exhibiting antrimicrobial activity against several human pathogens. Here, we analyzed the effect against Staphyloccocus aureus of an extended peptide (TcPaSK) containing two additional amino acids, lysine and asparagine, flanking the former peptide fragment in the original insect defensi…
Studies on the genus Atriplex (Chenopodiaceae) in Italy. VIII. Names published by Vincenzo Tineo and Michele Lojacono-Pojero
2023
The typification of the Atriplex names published by Vincenzo Tineo and Michele LojaconoPojero is discussed. Atriplex ambigua, A. dealbata, A. graeci, A. halimoides, A halimoides var. glomerata, A. halimoides var. perglauca, A. polyphylla, and A. ratundifolia are neo- or lectotypified on specimens preserved at FI or PAL and ynonymized with A. glauca (= A. dealbata), A. halimus (= A. halimoides = A. halimoides var. glomerata = A. halimoides var. perglauca), A. rosea (= A. ambigua = A. graeci) and A. tornabenei (= A. polyphylla = A. rotundifolia). The Tineo’s A. arenaria, previously considered as replaced synonym of A. tornabenei, is clarified and typified (neotype) on a specimens deposited at…
Combined treatment of caffeic acid and DMAPT induces AMPK dependent death in MDA-MB231 cells
Alterità ed esotismo nella commedia per musica napoletana del Settecento: la «Dardanè» di Cerlone e Paisiello e le sue fonti
2019
Francesco Cerlone and Giovanni Paisiello's comic opera "Dardanè" was performed for the first time in Naples in 1772. Its plot revolves around a peculiar theme from Middle Eastern religious and cultural tradition: the 'triple talak', i.e. the Muslim practice of instant divorce. The article investigates the fortune of this topic in European litterature and theatre. The intertextual itinerary starts from the collection of pseudo-Persian tales "Les milles et un jours" by Pétis de la Croix (Paris 1710-1712); other important steps are two pièces with the same title, "Arlequin hulla", the first one by Lesage and d'Orneval (Paris 1716), and the second one by Biancolelli and Romagnesi (Paris 1728). …
EFFECTS OF CELLULAR SHORT-TERM STARVATION ON CONVENTIONAL CHEMOTHERAPY RESPONSE IN HUMAN CANCER: UNDERSTANDING OF MOLECULAR MECHANISMS AND MICRORNAS …
Background: Short Term Starvation (STS) is a type of dietary restriction able to reduce tumorigenesis and cancer progression but molecular bases of this effect are still unclear. Aim: In vitro analysis of STS effects in presence of chemotherapy and evaluation of microRNAs (miRNAs) involvement. Results: STS affects the expression profiles of miRNAs involved in chemotherapy response leading to cancer cells sensitization and to healthy cells protection.