Search results for "TRIPLE"
showing 10 items of 506 documents
Through space singlet-singlet and triplet-triplet energy transfers in cofacial bisporphyrins held by the carbazoyl spacer
2007
The through space singlet-singlet and triplet-triplet energy transfers in cofacial bis(etio-porphyrins) rigidly held by the carbazoyl spacer were investigated. The studies on singlet-singlet transfer, which operates via a Förster mechanism, were performed using the zinc porphyrin and free base chromophores as energy donor and acceptor, respectively, while the investigation on triplet-triplet processes was performed using the palladium porphyrin, and the zinc porphyrin and free base chromophores as donor and acceptors, respectively. The rate for singlet-singlet transfer ( k ET ( singlet )) is unexpectedly slower than that reported for other similar, rigidly held bisporphyrins such as H 2( D…
Triple-Negativity Identifies a Subgroup of Patients with Better Overall Survival in Essential Thrombocythemia
2022
Essential thrombocythemia, as defined by the WHO in 2016, is a Philadelphia-negative chronic myeloproliferative neoplasm showing a better prognosis than polycythemia vera and myelofibrosis. In a variable percentage, patients with essential thrombocythemia show none of the known driver-gene mutations that may occur on JAK2, CALR, and MPL genes. Such patients are classified as triple-negative and their clinical features and prognosis have not been described with precision yet. In this study, we evaluated some of the characteristics of this population by comparing them with those of patients with driver-gene mutated ET. Data from 266 consecutive essential thrombocythemia patients were analysed…
How to make a transverse triple junction—New evidence for the assemblage of Gondwana along the Kaoko-Damara belts, Namibia
2016
T-shaped orogenic triple junctions between mobile belts usually form in two unrelated stages by subsequent and oblique continental collisions separated by a significant time span. Besides these “oblique triple junctions”, another type, named “transverse triple junctions”, may exist. Such junctions are created by a more complex mechanism of partly contemporaneous convergence of three cratons in a restricted time frame, involving strike slip. The Neoproterozoic–Cambrian Kaoko-Damara junction between the Rio de la Plata, Congo, and Kalahari cratons in Namibia is an example of such a transverse orogenic triple junction, formed by at least four subsequent but partly related deformation events. I…
Alternative feed resources and their effects on the quality of meat and milk from small ruminants
2008
The present paper reviews the quality of meat and milk from sheep and goats offered alternative feeds as a replacement for concentrates. Legume seeds and pods, shrubs, local agro-industrial by-products or novel pasture species are cheap and widely available in Mediterranean countries and are suitable for sheep and goat nutrition. Many of these alternative feed resources (AFR) contain secondary compounds, such as tannins. Tannin-containing feeds result in meat of a lighter colour and tend to increase milk yield and protein content, probably because they protect dietary proteins from ruminal degradation. Conjugated linoleic acid (CLA) content in kid meat can be increased by feeding animals ch…
Triple Helix modeļa pielietojuma iespējas starta uzņēmējdarbības vides veidošanā: Latvijas, Somijas un Igaunijas situāciju analīzes.
2016
Maģistra darba tēma ir Triple Helix modeļa pielietojuma iespējas starta uzņēmējdarbības vides veidošanā: Latvijas, Somijas un Igaunijas situāciju analīzes. Starta uzņēmējdarbība strauji attīstās visā pasaulē un aizvien pieaug to popularitāte un palielinās to nozīme valstu ekonomiku attīstībā. Šajā maģistra darbā tiek padziļināti pētītas un iepazītas trīs valstu starta uzņēmējdarbības vides, lai spētu izprast, kas starta uzņēmējdarbības vides padara veiksmīgas un efektīvas. Šī darba mērķis ir izveidot Latvijas Triple Helix modeli un to salīdzināt ar Igaunijas un Somijas Triple Helix modeļiem, lai varētu noteikt iemeslus kādēļ Latvijas starta uzņēmējdarbības vide atpaliek no iepriekšminēto va…
N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
2015
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cel…
Contextuality Analysis of the Double Slit Experiment (with a Glimpse into Three Slits)
2018
The Contextuality-by-Default theory is illustrated on contextuality analysis of the idealized double-slit experiment. The experiment is described by a system of contextually labeled binary random variables each of which answers the question: Has the particle hit the detector, having passed through a given slit (left or right) in a given state (open or closed)? This system of random variables is a cyclic system of rank 4, formally the same as the system describing the Einsten-Podolsky-Rosen-Bell paradigm with signaling. Unlike the latter, however, the system describing the double-slit experiment is always noncontextual, i.e., the context-dependence in it is entirely explainable in terms of d…
Correction to: A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matchin…
2019
The Acknowledgments section of this article has been corrected to 1) correct the formatting of Arianna Di Napoli's name to 'DiNapoli A', and 2) to include the name of Alessandro Corsi which was omitted in the original Lazio Group of Haematopathologist list. No further changes have been made to the publication. The corrected Acknowledgments section is as follows:.
Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer
2019
There is still a great unmet medical need concerning diagnosis and treatment of breast cancer which could be addressed by utilizing specific molecular targets. Tumor-associated MUC1 is expressed on over 90 % of all breast cancer entities and differs strongly from its physiological form on epithelial cells, therefore presenting a unique target for breast cancer diagnosis and antibody-mediated immune therapy. Utilizing an anti-tumor vaccine based on a synthetically prepared glycopeptide, we generated a monoclonal antibody (mAb) GGSK-1/30, selectively recognizing human tumor-associated MUC1. This antibody targets exclusively tumor-associated MUC1 in the absence of any binding to MUC1 on health…
(+)-Dehydroabietylamine derivatives target triple-negative breast cancer.
2015
Breast cancer remains the leading cause of cancer-related death among women. The invasive triple-negative subtype is unresponsive to estrogen therapy, and few effective treatments are available. In search of new chemical scaffolds to target this disease, we conducted a phenotypic screen against the human breast carcinoma cell lines MDA-MB-231, MA11, and MCF-7 using terrestrial natural products. Natural products that preferentially inhibited proliferation of triple-negative MDA-MB-231 cells over estrogen receptor-positive cells were further studied; herein we focused on the abietanes. The activity of the abietane carnosol prompted us to generate a focus library from the readily available (+)…