Search results for "TRIX"

Aberrant glycosylation of alpha-dystroglycan causes defective binding of laminin in the muscle of chicken muscular dystrophy.

2005

Dystroglycan is a central component of dystrophin-glycoprotein complex that links extracellular matrix and cytoskeleton in skeletal muscle. Although dystrophic chicken is well established as an animal model of human muscular dystrophy, the pathomechanism leading to muscular degeneration remains unknown. We show here that glycosylation and laminin-binding activity of alpha-dystroglycan (alpha-DG) are defective in dystrophic chicken. Extensive glycan structural analysis reveals that Galbeta1-3GalNAc and GalNAc residues are increased while Siaalpha2-3Gal structure is reduced in alpha-DG of dystrophic chicken. These results implicate aberrant glycosylation of alpha-DG in the pathogenesis of mus…

Extracellular matrix regulation of PTHrP and PTH/PTHrP receptor in a human breast cancer cell line

1999

AbstractIt was previously reported that 8701-BC breast cancer cells express the gene for parathyroid hormone-related peptide (PTHrP) and its cognate receptor (PTHrP-R), and release immunoreactive PTHrP in the extracellular medium; it was also found that PTHrP, in turn, exerts a role on the proliferative and invasive behavior in vitro of the same cell line. On the other hand, evidence has been produced that adhesion of 8701-BC cells onto different collagen substrates influences in various ways a number of phenotypic expressions, such as cell growth, motility, invasion of reconstituted basement membrane and production of lytic enzymes of the extracellular matrix (ECM). In light of these previ…

AS “LVM” kokaudzētavas “Mazsili” mārketinga vides analīze un attīstības perspektīvas Kurzemē.

2019

Kvalifikācijas darba autore: Aija Vanaga Kvalifikācijas darba tēma: Kokaudzētavas „Mazsili” mārketinga vides analīze un attīstības perspektīvas Kurzemē. Studiju programma: Pirmā līmeņa profesionālās augstākās izglītības studiju programmas „Komercdarbības organizācija ar specializāciju” „Tirgzinības un tirdzniecības speciālists” Kvalifikācijas darba zinātniskais vadītājs: Mg.paed. Inta Kalniņa Kvalifikācijas darbā tiek pētīts/analizēts :uzņēmuma mārketinga vide un attīstības perspektīvas kokaudzētavā. Darba mērķis: ir pamatojoties uz apkopoto zinātnisko literatūru par mārketinga vidi, veikt kokaudzētavas „Mazsili” mārketinga vides analīzi un izstrādāt priekšlikumus konkurences attīstībai Kur…

Il ruolo di molecole POSS(polyhedral oligomeric silsesquioxane) sulle relazioni proprietà struttura nei nanocompositi a base polistirenica

2012

Stick around: Cell–Cell Adhesion Molecules during Neocortical Development

2021

The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to establish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contact with additional cells. In this review, we will focus on the role of two important families of cell–cell adhesion molecules (C-CAMs), classi…

Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study

2022

Introduction: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have recently been proposed as promising biomarkers in different immune-mediated disorders. We evaluated the plasma levels of MMP-9 and MMP-2 and their tissue inhibitors TIMP-1 and TIMP-2 in a patients’ cohort with generalized myasthenia gravis (MG). Methods: Plasma concentrations of MMP-9, MMP-2, TIMP-1 and TIMP-2 were evaluated in 14 patients with generalized MG and 13 age- and sex-matched healthy controls. The severity of disease was assessed by the modified Osserman classification. Results: Compared to the healthy subjects, MG patients had increased plasma concentrations of MMP-9, but redu…

Phenomenology of non-standard neutrino interactions

2016

Today neutrino physics is in a privileged position within the fascinating field of particle physics. From the discovery of neutrino oscillations by Super-Kamiokande in 1998, the door to physics beyond the Standard Model (SM in what follows) has been opened. This fact implies that neutrinos have to be massive in opposition to the Standard Model assumption. However, this is not a surprise completely, but it was already hinted from theoretical and experimental observations in the two decades prior to the discovery of the oscillatory phenomenon, as neutrino masses included in unification models or the observed deficit of the atmospheric and solar neutrino fluxes. As a consequence of this new pa…

Vibrational Spectrum of HXeSH revisited : Combined computational and experimental study

2020

Vibrational spectrum of HXeSH embedded in low-temperature matrix is experimentally studied. To support the spectrum interpretation, anharmonic vibrational analysis is performed using different models and basis sets and the data is compared with previous experimental and theoretical analyses. Computations of overtones and combination modes allowed for new band assignments. The HXeSH molecule exhibits high anharmonicity similarly as other molecules from the noble-gas hydride family. Comparison of the employed computational methods shows once again that the modelling of the noble-gas compounds faces theoretical challenges to yield quantitatively reliable results. peerReviewed

Information Extraction from Binary Skill Assessment Data with Machine Learning

2021

Strength training exercises are essential for rehabilitation, improving our health as well as in sports. For optimal and safe training, educators and trainers in the industry should comprehend exercise form or technique. Currently, there is a lack of tools measuring in-depth skills of strength training experts. In this study, we investigate how data mining methods can be used to identify novel and useful skill patterns from a binary multiple choice questionnaire test designed to measure the knowledge level of strength training experts. A skill test assessing exercise technique expertise and comprehension was answered by 507 fitness professionals with varying backgrounds. A triangulated appr…

A Simple, High-Yield Method for Assessing Structural Novelity

2013

The structural dimension of music plays an important role in its affective appreciation. One particular aspect is related to the temporal succession of moments, each characterized by particular musical properties. One classical approach in computational modelling of this aspect is based on similarity matrix representations, where successive states are visualized by successive squares along the main diagonal, bearing some resemblance to checkerboards. One referential method estimates a so-called novelty curve, representing the probability along time of the presence of transitions between successive states, as well as their relative importance. Novelty is traditionally computed by comparing –…