Search results for "TRKB"

showing 3 items of 23 documents

BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

2022

Conventional antidepressants are widely employed in several psychiatric and neurologic disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are only gradually being understood. This narrative review provides an up-to-date overview of the interplay between antidepressant treatment and Brain-Derived Neurotrophic Factor (BDNF) signaling. In addition, the impact of nutritional, environmental and physiological factors on BDNF and the antidepressant response is outlined. This review underlines the necessity to include information on lifestyle choices in testing and developing antidepressant treatments in the future.

antidepressantBrain-Derived Neurotrophic FactorOrganic ChemistryTrkBGeneral MedicineAntidepressive AgentsCatalysisComputer Science ApplicationsInorganic ChemistryBDNFdepressionSettore BIO/14 - FarmacologiaPhysical and Theoretical ChemistryMolecular BiologyenvironmentSpectroscopySignal Transduction
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Abnormal development of pacinian corpuscles in double trkB;trkC knockout mice.

2006

Pacinian corpuscles depend on either Aalpha or Abeta nerve fibers of the large- and intermediate-sized sensory neurons for the development and maintenance of the structural integrity. These neurons express TrkB and TrkC, two members of the family of signal transducing neurotrophin receptors, and mice lacking TrkB and TrkC lost specific neurons and the sensory corpuscles connected to them. The impact of single or double targeted mutations in trkB and trkC genes in the development of Pacinian corpuscles was investigated in 25-day-old mice using immunohistochemistry and ultrastructural techniques. Single mutations on trkB or trkC genes were without effect on the structure and S100 protein expr…

medicine.medical_specialtyanimal structuresTropomyosin receptor kinase BBiologyTropomyosin receptor kinase CS100 proteinMiceMicroscopy Electron TransmissionInternal medicinemedicineLow-affinity nerve growth factor receptorAnimalsReceptor trkBReceptor trkCReceptorMice Knockoutmusculoskeletal neural and ocular physiologyGeneral NeuroscienceImmunohistochemistryCell biologyMice Inbred C57BLEndocrinologynervous systemAnimals NewbornTrk receptorembryonic structuresKnockout mousebiology.proteinPacinian CorpusclesNeurotrophinNeuroscience letters
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Impact of pharmacological and environmental manipulations on neuronal structural plasticity and dynamics

2017

El sistema nervioso de vertebrados es uno de los más estudiados, aunque peor comprendidos, del organismo de mamíferos. Desde que Ramón y Cajal postuló su teoría celular de este sistema (Ramón y Cajal 1909), la neurona se ha postulado como su unidad funcional. Sin embargo, durante las últimas décadas se ha revolucionado la visión que se tenía de éste. Una de las percepciones más asentadas era que, tras el desarrollo embrionario, el sistema nervioso se mantenía inmutable. Sin embargo, ahora sabemos que diferentes formas de plasticidad gobiernan su adaptación, que son necesarias para importantes procesos del día a día, tales como el aprendizaje y la memoria (Smythies 2002; Berlucchi and Buchte…

nmdamk-801somatosensory cortexhippocampus:CIENCIAS DE LA VIDA::Neurociencias [UNESCO]neuronal dynamics78-dihydroxyflavoneUNESCO::CIENCIAS DE LA VIDA::Fisiología humana ::Neurofisiologíatrkbneuronal plasticityhole-board test2-photon microscopyopen fieldprefrontal cortexinterneuronsfluoxetineUNESCO::CIENCIAS DE LA VIDA::Biología celularnmda receptorsamygdalacranial windowsschizophrenianovel object recognition test:CIENCIAS DE LA VIDA::Biología celular [UNESCO]UNESCO::CIENCIAS DE LA VIDA::Neurociencias:CIENCIAS DE LA VIDA::Fisiología humana ::Neurofisiología [UNESCO]
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