Search results for "TSA"
showing 10 items of 521 documents
Plasmonic Nanosensors for the Determination of Drug Effectiveness on Membrane Receptors.
2016
We demonstrate the potential of the NanoSPR (nanoscale surface plasmon resonance sensors) method as a simple and cheap tool for the quantitative study of membrane protein–protein interactions. We use NanoSPR to determine the effectiveness of two potential drug candidates that inhibit the protein complex formation between FtsA and ZipA at initial stages of bacterial division. As the NanoSPR method relies on individual gold nanorods as sensing elements, there is no need for fluorescent labels or organic cosolvents, and it provides intrinsically high statistics. NanoSPR could become a powerful tool in drug development, drug delivery, and membrane studies.
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subse…
2018
Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective. We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma.…
Native arbuscular mycorrhizal symbiosis alters foliar bacterial community composition.
2017
The effects of arbuscular mycorrhizal (AM) fungi on plant-associated microbes are poorly known. We tested the hypothesis that colonization by an AM fungus affects microbial species richness and microbial community composition of host plant tissues. We grew the grass, Deschampsia flexuosa in a greenhouse with or without the native AM fungus, Claroideoglomus etunicatum. We divided clonally produced tillers into two parts: one inoculated with AM fungus spores and one without AM fungus inoculation (non-mycorrhizal, NM). We characterized bacterial (16S rRNA gene) and fungal communities (internal transcribed spacer region) in surface-sterilized leaf and root plant compartments. AM fungus inoculat…
Socialt stöd, känsla av ensamhet och psykiska besvär bland finlandssvenska ungdomar
2021
I den här studien utforskades ifall det förekommer sociodemografiska skillnader i upplevelse av psykiska besvär, socialt stöd och känsla av ensamhet bland finlandssvenska ungdomar. Det undersöktes även ifall ungdomarnas upplevelse av psykiska besvär kan förklaras med familje-, kamrat- och klasskamratstöd samt känsla av ensamhet. Utöver det utforskades ifall samband mellan socialt stöd och psykiska besvär kan förklaras med känsla av ensamhet.
 Som datamaterial användes WHO:s skolelevstudie (WHO-Koululaistutkimus) från 2018 med ett deltagarantal på 599 svenskspråkiga elever från årskurs 5, 7 och 9 (Målder = 11,9/14,0/15,9; svarsprocent 38 %). Som statistiska analysmetoder användes Pearso…
Effectiveness of child protection practice models : a systematic review
2020
Background Attempts to improve child protection outcomes by implementing social work practice models embedded in a particular theory and practice approach, have increased internationally over the past decade. Objective To assess the evidence of the effectiveness of child protection practice models in improving outcomes for children and families. Participants and setting Children < 18 years and their families involved in child protection services. Methods A systematic review was conducted to synthesize evidence regarding the effectiveness of child protection practice models. Systematic searches across 10 electronic databases and grey literature were conducted to identify quasi-experimental s…
Impact of Urinary Incontinence on Physical Function and Respiratory Muscle Strength in Incontinent Women : A Comparative Study between Urinary Incont…
2022
Patients with stress urinary incontinence (SUI) may be afraid to increase intra-abdominal pressure to avoid incontinence. This could lead to weak expiratory muscles. The aim of this study was to investigate the association between respiratory muscle strength, physical function, and SUI in patients with SUI. A cross-sectional study was conducted in the Physical Medicine and Functional Rehabilitation Department. Thirty-one incontinent women (IG) and twenty-nine women in a control group (CG) were enrolled in this study. Anthropometric data, respiratory muscle strength (maximal inspiratory pressure; maximal expiratory pressure), SUI (Urogenital Distress Inventory-6; Incontinence Impact Question…
PISA 2012 : resultatnivån i de svenskspråkiga skolorna i Finland
2014
Rotaļnodarbība 3-4 gadus vecu bērnu emocionālās atsaucības sekmēšanai
2022
Bakalaura darba nosaukums ir “Rotaļnodarbība 3-4 gadus vecu bērnu emocionālās atsaucības sekmēšanai”, darba autors Monta Strazdiņa. Darba mērķis: Teorētiski un praktiski izzināt 3-4 gadus vecu bērnu emocionālās atsaucības veidošanos rotaļnodarbībā. Bērnu emocionālās atsaucības sekmēšanai caur rotaļu ir ļoti liela nozīme. Ir aktuāli jau pirmsskolas periodā attīstīt bērna emocionālo atsaucību, jo emocionālā atsaucība ir viena no svarīgākajām spējām, kas cilvēkam tiek piešķirtas. Ir pierādīts, ka cilvēka emocionālās pratības attīstības pakāpe nosaka viņa vispārējo labsajūtu Darba teorētiskajā daļā autore analizē pedagogu Ž.Piažē, A. Ļubļinska, D. Dzintere un D. Abakuka, u.c. autoru atziņas par…
Emergencia planetaria : necesidad de un planteamiento global
2007
Las noticias de degradación ambiental han saltado a las primeras páginas y editoriales de los periódicos y las reclamaciones ciudadanas empiezan a multiplicarse. Todo parece indicar que estamos asistiendo a una progresiva toma de conciencia. Sin embargo, las incomprensiones y las reticencias a la modificación de comportamientos siguen siendo graves, con una fuerte tendencia a los planteamientos parciales y al reduccionismo causal, ignorando la estrecha vinculación de los problemas y la necesidad de abordarlos conjuntamente. El objetivo de este trabajo es, precisamente, mostrar la vinculación de los problemas que caracterizan la actual situación de emergencia planetaria, que no se limitan al…
Emoticonos y multimodalidad. El uso del pulgar hacia arriba en WhatsApp
2016
El presente trabajo propone una aproximación multimodal al estudio de los emoticonos a través del análisis del uso del emoji del pulgar hacia arriba en un corpus de mensajes de WhatsApp. Además de contribuir a superar la idea, todavía muy arraigada, de que los emoticonos sirven para expresar emociones en el discurso digital, el trabajo toma en consideración algunos aspectos tradicionalmente obviados en el estudio sobre estas pequeñas caras, en concreto, la historia que hay detrás de estos recursos semióticos, la sofisticada relación entre imagen y texto y la interacción entre los usuarios en la vida real y en la pantalla. In the present paper a multimodal approach to the study of emoticons …